GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Milnacipran (Savella)

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Usual Dosing (Adults)

Fibromyalgia; the source states not approved for pediatric use. Take orally with or without food; food may improve tolerability. Day 1: 12.5 mg once. Days 2-3: 12.5 mg twice daily. Days 4-7: 25 mg twice daily. After day 7: 50 mg twice daily (recommended 100 mg/day). Depending on response, increase to 100 mg twice daily; doses above 200 mg/day were not studied. Taper rather than abruptly stopping after extended treatment.

Renal Dosing

Mild impairment: no adjustment. Moderate impairment: caution. Severe impairment, estimated CrCl 5-29 mL/min: reduce maintenance by 50% to 25 mg twice daily; may increase to 50 mg twice daily according to response.

Hemodialysis

Not recommended in end-stage renal disease.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/milnacipran/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/milnacipran/

Usual Dosing (Adults)

Fibromyalgia; the source states not approved for pediatric use. Take orally with or without food; food may improve tolerability. Day 1: 12.5 mg once. Days 2-3: 12.5 mg twice daily. Days 4-7: 25 mg twice daily. After day 7: 50 mg twice daily (recommended 100 mg/day). Depending on response, increase to 100 mg twice daily; doses above 200 mg/day were not studied. Taper rather than abruptly stopping after extended treatment.

GRPH-milnacipran-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Mild impairment: no adjustment. Moderate impairment: caution. Severe impairment, estimated CrCl 5-29 mL/min: reduce maintenance by 50% to 25 mg twice daily; may increase to 50 mg twice daily according to response.

GRPH-milnacipran-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Not recommended in end-stage renal disease.

GRPH-milnacipran-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/milnacipran/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
93ef7a166b193b38f5f954c5a77f5a5e73a34ba12f1c98c93d765b9736587a19
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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