GlobalRPh RX List - Glycerol phenylbutyrate (Ravicti)
- Product / population
- RAVICTI maintenance management of urea-cycle disorders; no acute hyperammonemia protocol supplied.
- Renal measure
- Renal impairment including ESRD/hemodialysis; ammonia monitoring.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
Safety and efficacy in renal impairment are unknown. Monitor ammonia closely when initiating treatment in patients with impaired renal function. Renal pharmacokinetics, including ESRD and hemodialysis, have not been studied. The hepatic impairment starting-dose advice elsewhere in the label is not a renal adjustment and must not be copied into a kidney-function table. No numeric renal regimen is established by the selected source.