GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Dulaglutide (Trulicity)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons

Trulicity

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Official source

TRULICITY - adult weekly titration and renal precautions

Product / population
Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Renal measure
No renal-function dose bands specified for this summary.

Dosing / renal protocol and limits

Adult type 2 diabetes: start 0.75 mg subcutaneously once weekly. After 4 weeks, increase to 1.5 mg weekly when needed; subsequent increases are 1.5 mg after at least 4 weeks at each dose, up to 4.5 mg weekly.

Renal impairment, including ESRD, does not require dose adjustment. Use caution in ESRD and monitor renal function with severe gastrointestinal reactions or volume depletion. The boxed thyroid C-cell-tumor warning and contraindications for personal/family medullary thyroid carcinoma or MEN2 remain applicable. This is not a pediatric dosing card.

Source revision: DailyMed updated 2026-06-16. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=463050bd-2b1c-40f5-b3c3-0a04bb433309

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

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Evidence sources and renal implications

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Official product label

TRULICITY - adult weekly titration and renal precautions

Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Retrieved: 2026-09-05

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Handbook

Renal Drug Handbook, 5th edition - Dulaglutide

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Handbook source

Renal Drug Handbook, 5th edition - Dulaglutide

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.

Historical renal / replacement-therapy guidanceRead this complete source summary

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Original content / product scopeTRULICITY - adult weekly titration and renal precautionsRenal Drug Handbook, 5th edition - Dulaglutide
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=463050bd-2b1c-40f5-b3c3-0a04bb433309

Product and population scope

Adult Dulaglutide (Trulicity). Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-dulaglutide · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

TRULICITY - adult weekly titration and renal precautions

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NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Source date: DailyMed updated 2026-06-16.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adult type 2 diabetes: start 0.75 mg subcutaneously once weekly. After 4 weeks, increase to 1.5 mg weekly when needed; subsequent increases are 1.5 mg after at least 4 weeks at each dose, up to 4.5 mg weekly.

Renal impairment, including ESRD, does not require dose adjustment. Use caution in ESRD and monitor renal function with severe gastrointestinal reactions or volume depletion. The boxed thyroid C-cell-tumor warning and contraindications for personal/family medullary thyroid carcinoma or MEN2 remain applicable. This is not a pediatric dosing card.

RDM30-082-dulaglutide-1 · Source locator: TRULICITY - adult weekly titration and renal precautions; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=463050bd-2b1c-40f5-b3c3-0a04bb433309
Retrieved
2026-09-05
DailyMed Set ID
463050bd-2b1c-40f5-b3c3-0a04bb433309
Renal-function method
No renal-function dose bands specified for this summary.
Source date/version
DailyMed updated 2026-06-16.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
485be3aa3dd7637ff15d05918f38629385a0cea1ba9f4ab86b4ef34c3066bf9c
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, 5th edition - Dulaglutide

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UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date: 5th edition; 2019 copyright; historical reference
Retrieved: 2026-09-05

Historical handbook cross-check; not a current U.S. protocol

Historical renal / replacement-therapy guidance

The book retains usual dosing at 30-50 mL/min and adds caution at 10-30 and <10. PD/HD/high-flux follow the <10 band; continuous therapy follows 10-30; removal is considered unlikely. It explicitly contrasts older UK caution below 30 with U.S. no-reduction advice. Its 0.75-1.5 mg weekly range predates current U.S. higher strengths and must not define the present maximum. Monitor dehydration-associated kidney injury.

HB30-dulaglutide-1 · Source locator: Printed page 351: renal impairment, RRT and other information

Source-specific limits

Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 351; uploaded PDF p. 370
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date/version
5th edition; 2019 copyright; historical reference
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=463050bd-2b1c-40f5-b3c3-0a04bb433309
Hash meaning
Local paraphrase; original book not redistributed
Local summary SHA-256
aaeefb5a2b0ccc84adc5716777b58236ab094888cd19fc519bab80120fa038b4

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=463050bd-2b1c-40f5-b3c3-0a04bb433309
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
bbc45335107ca2b66123e13a95b27bc964c812b7be4fa979ac4f1650ba754230
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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