GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Cimetidine

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Usual Dosing (Adults)

Treatment: 800 mg at bedtime, or 300 mg PO/IV every 6 hours, or 400 mg every 12 hours. Maintenance: 400 mg at bedtime. Esophagitis/reflux: 800 mg twice daily or 400 mg orally every 6 hours. Maximum 2400 mg/day.

Renal Dosing

CrCl >50 mL/min: no change. CrCl 10 to 50: 75% of usual dose at usual interval. CrCl <10: 50% of usual dose at usual interval.

Alternative strategy, ORAL: >30 mL/min no change; 15 to 30 usual dose every 8 hours; <15 usual dose every 12 hours.

Alternative strategy, IV: >50 mL/min 300 mg every 6 hours; 30 to 50 300 mg every 8 hours; 10 to 29 300 mg every 12 hours; <10 300 mg every 24 hours.

Hemodialysis

CrCl <10: give 50% of usual dose at usual interval. Some sources recommend 300 mg every 24 hours. Schedule doses after dialysis on dialysis days.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/cimetidine/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Retrieved: 2026-09-05

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/cimetidine/

Usual Dosing (Adults)

Treatment: 800 mg at bedtime, or 300 mg PO/IV every 6 hours, or 400 mg every 12 hours. Maintenance: 400 mg at bedtime. Esophagitis/reflux: 800 mg twice daily or 400 mg orally every 6 hours. Maximum 2400 mg/day.

GRPH-cimetidine-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl >50 mL/min: no change. CrCl 10 to 50: 75% of usual dose at usual interval. CrCl <10: 50% of usual dose at usual interval.

Alternative strategy, ORAL: >30 mL/min no change; 15 to 30 usual dose every 8 hours; <15 usual dose every 12 hours.

Alternative strategy, IV: >50 mL/min 300 mg every 6 hours; 30 to 50 300 mg every 8 hours; 10 to 29 300 mg every 12 hours; <10 300 mg every 24 hours.

GRPH-cimetidine-02 · Source section: Renal DosingRenal section finder

Hemodialysis

CrCl <10: give 50% of usual dose at usual interval. Some sources recommend 300 mg every 24 hours. Schedule doses after dialysis on dialysis days.

GRPH-cimetidine-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/cimetidine/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
718d7a34a008b2b98623b88d70d898555b3796e1d55d25f8f6cf8854f3d41ef2
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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