Original GlobalRPh source
- Product / population
- Preserved GlobalRPh source, not a freshly verified product label
- Renal measure
- Use the method specified in the original source
Historical source: not automatically current. Review current official labeling and separately attributed additions before use.
Source summary and narrative differ at exactly 20 and 60 mL/min. Both are retained; do not silently resolve the boundary.
Usual Dosing (Adults)
400 mg orally every 24 hours or 200 mg every 12 hours.
Renal Dosing
Source summary: CrCl >60 mL/min: 400 mg/day; 21 to 60: 300 mg/day; <=20: 200 mg/day.
Suprax may be administered in the presence of impaired renal function. Normal dose and schedule may be employed in patients with creatinine clearances of 60 mL/min or greater. Patients whose clearance is between 21 and 60 mL/min or who are on renal hemodialysis may be given 75% of the standard dosage at the standard dosing interval (300 mg daily). Patients whose clearance is <20 mL/min, or who are on continuous ambulatory peritoneal dialysis, may be given half the standard dosage (200 mg daily). Neither hemodialysis nor peritoneal dialysis removes significant amounts of the drug from the body.
Hemodialysis
See the renal dosing text above.