Aztreonam/avibactam - EMBLAVEO | GlobalRPh Renal Dosing Master

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Official source

EMBLAVEO (aztreonam and avibactam) for injection

Product / population: Adults; IV fixed combination; doses below are TOTAL combination grams.
Renal measure: Not specified; verify before use

Renal-adjusted loading and maintenance doses

Use Cockcroft-Gault CrCl in mL/min. All infusions last 3 hours.

>50: load 2.67 g, then 2 g every 6 hours.
>30 to 50: load 2.67 g, then 1 g every 6 hours.
>15 to 30: load 1.8 g, then 0.9 g every 8 hours.
<=15, including HD: load 1.33 g, then 0.9 g every 12 hours.

Timing and limits

Maintenance starts at the next dosing interval after the single load; intervals run from infusion start to infusion start. Give after HD on dialysis days and monitor changing renal function closely. The labeled course is 5-14 days with concurrent metronidazole. Approval rests on limited clinical safety/efficacy data.

Source revision: | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be1a6c99-d4b3-46d7-9e99-6e5f9fab556a

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Official product label

EMBLAVEO (aztreonam and avibactam) for injection

Adults; IV fixed combination; doses below are TOTAL combination grams.

Renal method: See source.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Official source

EMBLAVEO (aztreonam and avibactam) for injection

Adults; IV fixed combination; doses below are TOTAL combination grams.

Method: Not stated in selected source.

Renal-adjusted loading and maintenance doses Read this complete source summary

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Original content / product scope EMBLAVEO (aztreonam and avibactam) for injection

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be1a6c99-d4b3-46d7-9e99-6e5f9fab556a

Product and population scope

U.S. IV combination product for adults with complicated intra-abdominal infection and limited alternatives, used with metronidazole. Not single-agent aztreonam or ceftazidime/avibactam.

aztreonam-avibactam-emblaveo:scope · Source section: Selected U.S. label: product title, route, dosage form and indicationRenal section finder

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FDA / DailyMed dosing and renal information

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EMBLAVEO (aztreonam and avibactam) for injection

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NIH/NLM DailyMed - U.S. prescribing information · Adults; IV fixed combination; doses below are TOTAL combination grams.

Renal method: Not specified in this summary.
Source date:
Retrieved: 2026-09-05

Source-read local summary; source-specific recommendations are not automatically interchangeable.

Renal-adjusted loading and maintenance doses

Use Cockcroft-Gault CrCl in mL/min. All infusions last 3 hours.

>50: load 2.67 g, then 2 g every 6 hours.
>30 to 50: load 2.67 g, then 1 g every 6 hours.
>15 to 30: load 1.8 g, then 0.9 g every 8 hours.
<=15, including HD: load 1.33 g, then 0.9 g every 12 hours.

aztreonam-avibactam-emblaveo:dm-be1a6c99-d4b3-46d7-9e99-6e5f9fab556a-1 · Source locator: 2.1-2.2, Tables 1-2

Timing and limits

aztreonam-avibactam-emblaveo:dm-be1a6c99-d4b3-46d7-9e99-6e5f9fab556a-2 · Source locator: 1.1; 2.1-2.2; 8.6

Source identity and provenance

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
Retrieved: 2026-09-05
Exact label title: EMBLAVEO (aztreonam and avibactam) for injection
DailyMed Set ID: be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
Labeler: AbbVie Inc.
DailyMed page updated: 2026-06-24
FDA application: NDA marketing category; initial U.S. approval 2025
U.S. product identity basis: Exact named product and route appear in the selected U.S. prescription label; current retail availability was not independently assessed.
Hash meaning: Locally authored source summary, not original SPL/XML/PDF bytes
Local summary SHA-256: 4d82048cba4b5ec3004bac42ca815258da44cfbcc9313ded54b0220e509cc506

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=be1a6c99-d4b3-46d7-9e99-6e5f9fab556a
Source retrieval: 2026-09-05. This is not the source publication or label revision date.
Original source type: official new drug
Local text SHA-256: 1d76837c4fcc486ad931096684497fb48f0e45bc2ced635712eb7eae714cb76c
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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