GlobalRPh RX List - Vidaza
- Product / population
- VIDAZA subcutaneous/IV product; treatment-emergent renal toxicity, not oral azacitidine.
- Renal measure
- Serum bicarbonate, BUN and creatinine changes; not a baseline eGFR dosing table.
RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.
Renal dosing, restrictions and evidence limits
Check serum creatinine and electrolytes before therapy and with each cycle. For an unexplained bicarbonate decrease below 20 mEq/L, reduce the next course by 50%. For unexplained BUN or creatinine elevations, delay the next cycle until normal or baseline values return, then reduce the next course by 50%. These are toxicity-triggered modifications, not a universal initial CKD reduction. Renal impairment increases monitoring concerns and was excluded from relevant source trials. Do not transfer these injectable instructions to oral azacitidine.