Amantadine - OSMOLEX ER tablets | GlobalRPh Renal Dosing Master

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OSMOLEX ER: change dosing frequency and titration interval, not a daily fraction

The table uses MDRD indexed eGFR; other passages call the measure indexed CrCl. Reduced-frequency bands must not be converted into daily administration.

Before applying: Keep the two intervals distinct and reconcile source terminology; do not substitute a GOCOVRI schedule.

Also check: OSMOLEX ER: change dosing frequency and titration interval, not a daily fraction

Rxlist source

GlobalRPh RX List - OSMOLEX ER

Product / population: Amantadine - OSMOLEX ER tablets; selected source sections only, not a complete prescribing monograph.
Renal measure: eGFR, mL/min/1.73 m2; retain body-surface-area indexing. Table specifies MDRD; other passages instead say indexed CrCl.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

The renal table changes frequency and minimum titration interval, not the stated initial or maximum dose size. Table measure is MDRD eGFR (mL/min/1.73 m2):

60-89: one dose every 24 hours; increase no more often than weekly.

30-59: one dose every 48 hours; increase no more often than every 3 weeks.

15-29: one dose every 96 hours; increase no more often than every 4 weeks.

Below 15: contraindicated.

Other sections call the measure indexed creatinine clearance. This terminology discrepancy remains flagged. Do not interpret the phrase maximum daily dosage as permission for daily administration in the reduced-frequency bands.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-09. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/osmolex-er-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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GlobalRPh RX List

GlobalRPh RX List - OSMOLEX ER

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Amantadine - OSMOLEX ER tablets; selected source sections only, not a complete prescribing monograph.

Renal method: eGFR, mL/min/1.73 m2; retain body-surface-area indexing. Table specifies MDRD; other passages instead say indexed CrCl.
Retrieved: 2026-09-09

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OSMOLEX ER: change dosing frequency and titration interval, not a daily fraction

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OSMOLEX ER: change dosing frequency and titration interval, not a daily fraction

The table uses MDRD indexed eGFR; other passages call the measure indexed CrCl. Reduced-frequency bands must not be converted into daily administration.

How to use this: Keep the two intervals distinct and reconcile source terminology; do not substitute a GOCOVRI schedule.

GlobalRPh RX List - OSMOLEX ER Amantadine (source heading: Amantidine)GOCOVRI extended-release capsules: February 2026 label

Source-specific interpretation; independent clinician adjudication pending.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

Rxlist source

GlobalRPh RX List - OSMOLEX ER

Amantadine - OSMOLEX ER tablets; selected source sections only, not a complete prescribing monograph.

Method: eGFR, mL/min/1.73 m2; retain body-surface-area indexing. Table specifies MDRD; other passages instead say indexed CrCl.

Renal dosing, restrictions and evidence limits Read this complete source summary

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Original content / product scope GlobalRPh RX List - OSMOLEX ER

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/osmolex-er-drug/

Exact product and population

Amantadine - OSMOLEX ER tablets; selected source sections only, not a complete prescribing monograph.

RDM49-SCOPE-amantadine-osmolex-er · Source section: Selected source product scopeRenal section finder

Locally imported selected renal sections

GlobalRPh RX List renal information

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GlobalRPh RX List - OSMOLEX ER

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GlobalRPh-hosted RX List · Amantadine - OSMOLEX ER tablets; selected source sections only, not a complete prescribing monograph.

Renal method: eGFR, mL/min/1.73 m2; retain body-surface-area indexing. Table specifies MDRD; other passages instead say indexed CrCl.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-09

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

The renal table changes frequency and minimum titration interval, not the stated initial or maximum dose size. Table measure is MDRD eGFR (mL/min/1.73 m2):

60-89: one dose every 24 hours; increase no more often than weekly.

30-59: one dose every 48 hours; increase no more often than every 3 weeks.

15-29: one dose every 96 hours; increase no more often than every 4 weeks.

Below 15: contraindicated.

RDM49-rxlist-amantadine-osmolex-er-da2fdde60c-C1 · Source locator: Dosage table 1 and MDRD footnote, lines 44-55; renal subsection and contraindication, lines 246-263.

Source identity and provenance

Source family: product_label_mirror
Source: https://globalrph.com/rx-list/osmolex-er-drug/
Retrieved: 2026-09-09
Renal-function method: eGFR, mL/min/1.73 m2; retain body-surface-area indexing. Table specifies MDRD; other passages instead say indexed CrCl.
Source date/version: Source revision date not established in selected retrieval.
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: 562efc5d29fb09cb5a51ab6606cfb10fb0fe32275e1f2a301d0974336192324a

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/rx-list/osmolex-er-drug/
Source retrieval: 2026-09-09. This is not the source publication or label revision date.
Original source type: rxlist summary
Local text SHA-256: 3d71797f8b7e29293ebd87313025c82c82bfa228eef533e07c55969c3785b4be
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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