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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
All doses are total piperacillin plus tazobactam. The 30-minute source regimen is not an extended-infusion university regimen. The original PD summary and indication-specific CAPD table differ.
Check source scope before reading a dose
UCSF - dedicated extended-infusion protocol
Product / population
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal method
CrCl in mL/min where specified; no equation inferred.
Source revision
2024 revision named on page
Retrieved
2026-09-05
Local review status
Locally included source-specific summary. Regimen differences are not automatically resolved.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Three-hour and four-hour institutional protocols are not interchangeable
Sinai Health and UCSF differ in infusion duration, initial-to-maintenance timing, renal intervals and dialysis regimens. These are separate local pathways, not duplicate confirmations of one universal dose.
What to reconcile: Choose an approved institution-specific pathway with infection, susceptibility, dialysis settings and IV access documented. Do not pair one source's dose with the other's interval or loading sequence.
The RX short-infusion table separates nosocomial pneumonia and other indications and specifies an HD supplement. UCSF lists a different all-infection intermittent-HD schedule.
What to reconcile: Keep the chosen regimen, infusion duration, indication and dialysis assumptions intact. Do not add the label supplement automatically to an institution's different regimen. Exactly 20 is also unassigned by UCSF's printed greater-than/less-than headings.
UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal method: CrCl in mL/min where specified; no equation inferred. Source date: 2024 revision named on page Retrieved: 2026-09-05
Locally included source-specific summary. Regimen differences are not automatically resolved.
Dosing / renal protocol and limits
For CrCl >20 mL/min or CRRT: when loading is indicated, give 4.5 g IV over 30 minutes once, then immediately begin 4.5 g over 4 hours every 8 hours. This is an extended-infusion protocol, not an interchangeable short-infusion schedule.
For the separately listed short-infusion, non-Pseudomonas regimen: CrCl >=50, 3.375 g every 6 hours; 10-50, 3.375 g every 6-8 hours; <10, 2.25 g every 8 hours; HD, 2.25 g every 8 hours; CRRT, 4.5 g every 8 hours or 3.375 g every 6 hours. The source overlaps at exactly 50; clarify locally rather than silently changing the boundary.
Extended-infusion exclusions include resistant/intermediate organisms, cystic fibrosis, peri-procedural areas and inadequate IV access.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.