GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Piperacillin/tazobactam

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug8 sources available - open source summaries, references and comparisons

pip-tazo / Zosyn

READ THE SOURCE-SPECIFIC ANSWER

Renal guidance at a glance

Cautions / source differences (3)
Review first - source-specific qualification

The ZOSYN table is a 30-minute infusion protocol

The mirror separates nosocomial pneumonia from other adult indications and specifies total combination grams.

Before applying: Do not attach an extended-infusion duration or another source interval to these short-infusion doses.

Evidence for this qualification

Source-specific interpretation; independent clinician adjudication pending.

Confirm the product, indication and renal measure. The selected summary is not a complete prescribing monograph.

Choose a source to read (8)

Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

2 additional source qualifications - review before use
Three-hour and four-hour institutional protocols are not interchangeable

Sinai Health and UCSF differ in infusion duration, initial-to-maintenance timing, renal intervals and dialysis regimens. These are separate local pathways, not duplicate confirmations of one universal dose.

Before applying: Choose an approved institution-specific pathway with infection, susceptibility, dialysis settings and IV access documented. Do not pair one source's dose with the other's interval or loading sequence.

Label and UCSF dialysis instructions differ

The RX short-infusion table separates nosocomial pneumonia and other indications and specifies an HD supplement. UCSF lists a different all-infection intermittent-HD schedule.

Before applying: Keep the chosen regimen, infusion duration, indication and dialysis assumptions intact. Do not add the label supplement automatically to an institution's different regimen. Exactly 20 is also unassigned by UCSF's printed greater-than/less-than headings.

Also check: Three-hour and four-hour institutional protocols are not interchangeable; Label and UCSF dialysis instructions differ

Rxlist source

GlobalRPh RX List - ZOSYN

Product / population
ZOSYN adult, 30-minute IV infusion, indication-specific renal table. Not an extended-infusion or pediatric renal regimen.
Renal measure
Source-specific renal measure; see text

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Before using this finding

Confirm infusion duration and indication before comparing doses across sources.

No new official-label card was obtained for this product in v6.1. Earlier source layers, if present, were retained but not rechecked.

Renal guidance and important limits

These adult doses are total grams of piperacillin/tazobactam, infused over 30 minutes.

CrCl / dialysisOther indicationsNosocomial pneumonia
Above 40 mL/min3.375 g every 6 hours4.5 g every 6 hours
20-40 mL/min2.25 g every 6 hours3.375 g every 6 hours
Below 20 mL/min2.25 g every 8 hours2.25 g every 6 hours
Hemodialysis2.25 g every 12 hours2.25 g every 8 hours
CAPD2.25 g every 12 hours2.25 g every 8 hours

For hemodialysis, the source adds 0.75 g after each session on dialysis days; CAPD requires no additional dose. Pediatric renal dosing is not established in this source. Do not combine these doses with a different institution's extended-infusion interval.

Source revision: Revision not established in selected retrieval | Retrieved: 2026-09-10. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/zosyn-drug/

Scope: Selected source sections stored locally. Not a complete monograph or independent clinical approval. GlobalRPh v6.6.

Full source card / provenance

All sources, comparison tools and evidence navigation
Source-specific interpretation

What the dialysis evidence actually supports

Removal information alone does not define a maintenance dose, supplemental dose or dialysis schedule. A reported regimen still requires its product, indication, renal measure and dialysis assumptions to match the patient.

GlobalRPh RX List - ZOSYN

Authored v6.1; retrieved 2026-09-10 - retained source, not freshly reviewed in this release

A regimen is reported in selected content

Read the source and its limits

These manual classifications apply only to the identified selected sections, not every retained source or the entire prescribing information. They are not dosing clearance.

Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 3 source difference / applicability notes

Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
GlobalRPh RX List

GlobalRPh RX List - ZOSYN injection

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult IV piperacillin/tazobactam, total combination grams, 30-minute infusion.

Renal method: Adult creatinine clearance, mL/min; HD and CAPD distinguished.
Retrieved: 2026-09-07

Read local renal resultOpen original reference
GlobalRPh RX List

GlobalRPh RX List - ZOSYN

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Confirm infusion duration and indication before comparing doses across sources.

Dialysis evidence: A regimen is reported in selected content

ZOSYN adult, 30-minute IV infusion, indication-specific renal table. Not an extended-infusion or pediatric renal regimen.

Renal method: Source-specific renal measure; see text
Retrieved: 2026-09-10

Read local renal resultOpen original reference
Professional guidance

UCSF/ZSFG - piperacillin-tazobactam infusion-specific protocols

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
Professional guidance

Stanford - piperacillin/tazobactam extended infusion

Adults; IV fixed combination, guide page 7. Select one strategy.

Renal method: CrCl in mL/min; IHD and CRRT distinct.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
Professional guidance

UCSF - dedicated extended-infusion protocol

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
Professional guidance

UCSF piperacillin/tazobactam - extended infusion and dialysis

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

UCSF adult institutional policy; total combination grams. Exclusions and dialysis setting must match.

Renal method: Adult CrCl, mL/min; intermittent versus continuous HD.
Retrieved: 2026-09-07

Read local renal resultOpen original reference
Professional guidance

Sinai Health piperacillin/tazobactam - November 2025 policy

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Sinai Health adult inpatient policy effective November 2025; not an independently approved U.S. label regimen.

Renal method: Adult CrCl, mL/min; IHD, PD and CRRT listed separately.
Retrieved: 2026-09-07

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Find text within this drug
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Search the stored clinical text

Locate a word or phrase within this drug's source summaries. Choose all sources or one source to focus the search. The selection never hides warnings or source text, changes a dose, or proves that a renal finding is absent.

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All source summaries, original wording and provenance
Before applying a renal protocol

Check the setting. Compare whole sources.

No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.

Share a reproducible source review

Choose sources below, then open a print-ready comparison with product scope, renal method, dates and cautions. Links can pin the exact local cards; they never contain patient values or choose a dose.

Open / share selected sources
Jump to renal guidanceRead 3 difference / caution notesClinician guide

Select two distinct source versions. The complete stored summaries will appear below.

Build a source-review outline for documentation

This creates a blank decision outline with the source identities you select, not a dose recommendation or completed clinical assessment. No patient fields are collected, saved or sent. Complete the clinical decisions in your approved documentation system.

Choose one or two sources above or use the source checkboxes below.

Renal-context checklist: population, kidney trend and dialysis

These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.

Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.

See source-specific renal methods and the clinical interpretation guide for the supporting context.

Read before choosing a regimen

Source differences and product cautions

Search differences across all drugs

These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

institutional regimen difference

Three-hour and four-hour institutional protocols are not interchangeable

Sinai Health and UCSF differ in infusion duration, initial-to-maintenance timing, renal intervals and dialysis regimens. These are separate local pathways, not duplicate confirmations of one universal dose.

How to use this: Choose an approved institution-specific pathway with infection, susceptibility, dialysis settings and IV access documented. Do not pair one source's dose with the other's interval or loading sequence.

Sinai Health piperacillin/tazobactam - November 2025 policyUCSF piperacillin/tazobactam - extended infusion and dialysis

Source-specific interpretation; independent clinician adjudication pending.

label vs institutional guidance

Label and UCSF dialysis instructions differ

The RX short-infusion table separates nosocomial pneumonia and other indications and specifies an HD supplement. UCSF lists a different all-infection intermittent-HD schedule.

How to use this: Keep the chosen regimen, infusion duration, indication and dialysis assumptions intact. Do not add the label supplement automatically to an institution's different regimen. Exactly 20 is also unassigned by UCSF's printed greater-than/less-than headings.

GlobalRPh RX List - ZOSYN injectionUCSF piperacillin/tazobactam - extended infusion and dialysis

Source-specific interpretation; independent clinician adjudication pending.

source scope and renal guidance

The ZOSYN table is a 30-minute infusion protocol

The mirror separates nosocomial pneumonia from other adult indications and specifies total combination grams.

How to use this: Do not attach an extended-infusion duration or another source interval to these short-infusion doses.

GlobalRPh RX List - ZOSYN

Source-specific interpretation; independent clinician adjudication pending.

Go directly to the relevant source section

Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeGlobalRPh RX List - ZOSYN injectionGlobalRPh RX List - ZOSYNUCSF/ZSFG - piperacillin-tazobactam infusion-specific protocolsStanford - piperacillin/tazobactam extended infusionUCSF - dedicated extended-infusion protocolUCSF piperacillin/tazobactam - extended infusion and dialysisSinai Health piperacillin/tazobactam - November 2025 policy
Choose two source checkboxes below.
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

All doses are total piperacillin plus tazobactam. The 30-minute source regimen is not an extended-infusion university regimen. The original PD summary and indication-specific CAPD table differ.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/piperacillin-tazo/

Usual Dosing (Adults)

The introductory GlobalRPh range is 3.375 g every 4-6 hours or 4.5 g every 6-8 hours. The manufacturer section specifies 30-minute IV infusion, usually 3.375 g every 6 hours.

Historical presumptive nosocomial-pneumonia treatment: 4.5 g every 6 hours (18 g/day combined drug: 16 g piperacillin/2 g tazobactam) plus an aminoglycoside. Continue the aminoglycoside when P. aeruginosa is isolated; otherwise it may be stopped at the physician's discretion. Reconstitute, dilute and administer separately because beta-lactams can inactivate aminoglycosides. Adjust the aminoglycoside separately to its manufacturer instructions.

GRPH-piperacillin-tazo-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing - total combined grams

Limits that apply to these rows

Total combined grams; 30-minute IV infusion. Do not apply non-dialysis bands to HD. The separate historical PD narrative differs from its indication-specific CAPD table.

Other adult indications - IV
CrCl, mL/minSource-specific dose / instruction
>403.375 g every 6 hours
20-402.25 g every 6 hours
<202.25 g every 8 hours
Nosocomial pneumonia - IV
CrCl, mL/minSource-specific dose / instruction
>404.5 g every 6 hours
20-403.375 g every 6 hours
<202.25 g every 6 hours
Dialysis guidance - separate source-specific schedules
Piperacillin/tazobactam dialysis
Dialysis setting / indicationSource-specific schedule
HD - other indications2.25 g every 12 hours plus 0.75 g after each HD
HD - nosocomial pneumonia2.25 g every 8 hours plus 0.75 g after each HD
CAPD - other indications2.25 g every 12 hours; no supplement
CAPD - nosocomial pneumonia2.25 g every 8 hours; no supplement
Read the retained text before reformatting

Columns are non-nosocomial-pneumonia indications / nosocomial pneumonia:

  • CrCl above 40 mL/min: 3.375 g every 6 hours / 4.5 g every 6 hours.
  • CrCl 20-40: 2.25 g every 6 hours / 3.375 g every 6 hours.
  • CrCl below 20: 2.25 g every 8 hours / 2.25 g every 6 hours.
  • HD: 2.25 g every 12 hours / 2.25 g every 8 hours, plus 0.75 g after every HD session.
  • CAPD: 2.25 g every 12 hours / 2.25 g every 8 hours; no supplemental dose.

Non-dialysis CrCl bands do not apply to HD patients. HD removes approximately 30-40%.

GRPH-piperacillin-tazo-02 · Source section: Renal Dosing - total combined gramsRenal section finder

Original summary differences

The short introductory renal summary lists 40-90 mL/min at 3.375 g every 6 hours. The narrative comparison is written 'Creatinine Clearance = 40'; the complete table above is retained to show its actual band definitions.

The separate dialysis summary repeats the HD regimen and supplement, then states 'PD: 2.25 grams every 8 hours' without distinguishing indications. This differs from its CAPD table and is preserved as a source disagreement.

GRPH-piperacillin-tazo-03 · Source section: Original summary differencesRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - ZOSYN injection

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GlobalRPh-hosted RX List · Adult IV piperacillin/tazobactam, total combination grams, 30-minute infusion.

Renal method: Adult creatinine clearance, mL/min; HD and CAPD distinguished.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Adult total-combination doses infused over 30 minutes: for indications other than nosocomial pneumonia, CrCl above 40 uses 3.375 g every six hours; 20-40 uses 2.25 g every six hours; below 20 uses 2.25 g every eight hours. Nosocomial pneumonia uses 4.5 g, 3.375 g and 2.25 g every six hours in those respective bands. Hemodialysis or CAPD: 2.25 g every twelve hours for other indications, or every eight hours for nosocomial pneumonia. Hemodialysis also requires 0.75 g after each session; CAPD does not. These short-infusion regimens must not be combined with another institution's extended-infusion timing or renal intervals.

RDM37-rxlist-piperacillin-tazo-ab61ba44f3-C1 · Source locator: Dosage Table 1 and dialysis footnotes.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/zosyn-injection-drug/
Retrieved
2026-09-07
Renal-function method
Adult creatinine clearance, mL/min; HD and CAPD distinguished.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
d8f0275e952b666cc218a73edbc7ea05902f396f8035e74ebce425d7ab037162
Rxlist

GlobalRPh RX List - ZOSYN

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GlobalRPh-hosted RX List · ZOSYN adult, 30-minute IV infusion, indication-specific renal table. Not an extended-infusion or pediatric renal regimen.

Renal method: Source-specific renal measure; see text
Source date: Revision not established in selected retrieval
Retrieved: 2026-09-10

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding

Confirm infusion duration and indication before comparing doses across sources.

Dialysis evidence: A regimen is reported in selected content

Selected source sections stored locally. Not a complete monograph or independent clinical approval.

Renal guidance and important limits

These adult doses are total grams of piperacillin/tazobactam, infused over 30 minutes.

CrCl / dialysisOther indicationsNosocomial pneumonia
Above 40 mL/min3.375 g every 6 hours4.5 g every 6 hours
20-40 mL/min2.25 g every 6 hours3.375 g every 6 hours
Below 20 mL/min2.25 g every 8 hours2.25 g every 6 hours
Hemodialysis2.25 g every 12 hours2.25 g every 8 hours
CAPD2.25 g every 12 hours2.25 g every 8 hours

For hemodialysis, the source adds 0.75 g after each session on dialysis days; CAPD requires no additional dose. Pediatric renal dosing is not established in this source. Do not combine these doses with a different institution's extended-infusion interval.

RDM61-rxlist-piperacillin-tazo-3366d69645-C1 · Source locator: Dosage and Administration: renal impairment; named precautions

Source-specific limits

No new official-label card was obtained for this product in v6.1. Earlier source layers, if present, were retained but not rechecked.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/zosyn-drug/
Retrieved
2026-09-10
Renal-function method
Source-specific renal measure; see text
Source date/version
Revision not established in selected retrieval
Hash meaning
Local authored summary, not source HTML/XML/PDF bytes
Local summary SHA-256
1de940a75322356bc6953e205f5a5eabce42e67f5a90af631ea82ec2b3ad245a
Separate professional-source layer

University and professional protocols

Professional

UCSF/ZSFG - piperacillin-tazobactam infusion-specific protocols

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

UCSF extended infusion at CrCl >20 mL/min: 4.5 g IV over 30 minutes once, immediately followed by maintenance 4.5 g over 4 hours every 8 hours. Below 20 use short infusion; exactly 20 needs clarification. Exclusions include cystic fibrosis, resistant/intermediate organisms, peri-procedural settings and inadequate IV access.

Short-infusion non-Pseudomonas dosing: CrCl >50, 3.375 g every 6 hours; 10-50, 3.375 g every 8 hours; <10, 2.25 g every 8 hours. Suspected/documented Pseudomonas: >20, 4.5 g every 6 hours; <20, 3.375 g every 8 hours.

IHD: 2.25 g every 8 hours over 30 minutes. Continuous HD: UCSF uses the loading/extended-infusion schedule above; ZSFG uses 4.5 g every 8 hours over 30 minutes. These two institutional infusion strategies remain separate.

RDM30-053-piperacillin-tazo-1 · Source locator: UCSF/ZSFG - piperacillin-tazobactam infusion-specific protocols; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/piperacillin-tazobactam-zosyn
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
98fc85d00ed46a832437ba8dd03c1952d2dac8ea791a44726c2eada25e61bc8f
Professional

Stanford - piperacillin/tazobactam extended infusion

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Stanford Health Care Antimicrobial Safety and Sustainability · Adults; IV fixed combination, guide page 7. Select one strategy.

Renal method: CrCl in mL/min; IHD and CRRT distinct.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

For CrCl >20 mL/min, 3.375-4.5 g IV every 8 hours over 4 hours; below 20, 3.375 g every 12 hours over 4 hours. IHD general infection: 2.25 g every 12 hours; severe infection: 3.375 g every 12 hours over 4 hours. CRRT extended infusion: 3.375-4.5 g every 8 hours over 4 hours. The source also provides short-infusion alternatives.

RDM30-060-piperacillin-tazo-1 · Source locator: Stanford - piperacillin/tazobactam extended infusion; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-ABX-Dosing-Guide.pdf
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min; IHD and CRRT distinct.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
900cb5d51b2c47b7940599cf8e31ab9248587329ea52cc25e094a8143f8dd153
Professional

UCSF - dedicated extended-infusion protocol

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: 2024 revision named on page
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

For CrCl >20 mL/min or CRRT: when loading is indicated, give 4.5 g IV over 30 minutes once, then immediately begin 4.5 g over 4 hours every 8 hours. This is an extended-infusion protocol, not an interchangeable short-infusion schedule.

For the separately listed short-infusion, non-Pseudomonas regimen: CrCl >=50, 3.375 g every 6 hours; 10-50, 3.375 g every 6-8 hours; <10, 2.25 g every 8 hours; HD, 2.25 g every 8 hours; CRRT, 4.5 g every 8 hours or 3.375 g every 6 hours. The source overlaps at exactly 50; clarify locally rather than silently changing the boundary.

Extended-infusion exclusions include resistant/intermediate organisms, cystic fibrosis, peri-procedural areas and inadequate IV access.

RDM30-096-piperacillin-tazo-1 · Source locator: UCSF - dedicated extended-infusion protocol; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/piptazoextendedinfusion
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
2024 revision named on page
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
b0ebacf985bbaabe795734026157a659d36b863a52e2350fe3683d7abd927dab
Professional

UCSF piperacillin/tazobactam - extended infusion and dialysis

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UCSF Infectious Diseases Management Program · UCSF adult institutional policy; total combination grams. Exclusions and dialysis setting must match.

Renal method: Adult CrCl, mL/min; intermittent versus continuous HD.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For eligible adults with CrCl above 20 mL/min, UCSF uses 4.5 g over 30 minutes once, followed immediately by 4.5 g infused over four hours every eight hours. Below 20, use its short-infusion pathway; exactly 20 is not assigned by the printed greater-than/less-than headings. Exclusions include resistant/intermediate organisms, cystic fibrosis, peri-procedural areas and inadequate IV access. UCSF intermittent HD dosing is 2.25 g every eight hours over 30 minutes; continuous HD uses the extended-infusion load/maintenance strategy. These institutional schedules differ from both label short infusions and Sinai Health's three-hour policy. ZSFG has a different default infusion policy even on this UCSF page.

RDM37-professional-piperacillin-tazo-8ad3047bd0-C1 · Source locator: Non-dialysis extended infusion table; HD table; exclusions.

Source identity and provenance
Source family
professional_guidance
Source
https://idmp.ucsf.edu/content/piperacillin-tazobactam-zosyn
Retrieved
2026-09-07
Renal-function method
Adult CrCl, mL/min; intermittent versus continuous HD.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
20e77bbc88987a8ad0d542749d7e42e78023774977f1e5d4ce0d340ff31c5f6c
Professional

Sinai Health piperacillin/tazobactam - November 2025 policy

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Sinai Health Antimicrobial Stewardship · Sinai Health adult inpatient policy effective November 2025; not an independently approved U.S. label regimen.

Renal method: Adult CrCl, mL/min; IHD, PD and CRRT listed separately.
Source date: Policy starting November 2025
Retrieved: 2026-09-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For adult inpatients, this policy uses piperacillin/tazobactam 4.5 g with intervals of six hours at CrCl at least 40, eight hours at 20-39, and twelve hours below 20 mL/min. IHD and PD use 4.5 g every twelve hours; CRRT uses 4.5 g every six hours. Infuse the first dose over 30 minutes and subsequent doses over three hours. Start the next dose three hours after the initial dose, except below CrCl 20, IHD or PD, where the next dose starts six hours after the initial dose. Review actual administration times and IV access. This local policy permits exceptions after pharmacy, stewardship or infectious-disease review; it is not an interchangeable version of UCSF's four-hour regimen.

RDM37-professional-piperacillin-tazo-ff43ce8584-C1 · Source locator: New policy, eligibility, exceptions, dosing table.

Source identity and provenance
Source family
professional_guidance
Source
https://www.sinaihealth.ca/areas-of-care/antimicrobial-stewardship/clinical-summaries/extended-infusion-piperacillintazobactam
Retrieved
2026-09-07
Renal-function method
Adult CrCl, mL/min; IHD, PD and CRRT listed separately.
Source date/version
Policy starting November 2025
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
bac411daa4a9e9df2be17c10aaac01dc7808ae3bdeb9454429992a03c2bf0f25

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 2 RX List, 5 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/piperacillin-tazo/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
b474011b2002f36765ca65f0e03eeab5f34b0d6f6138b0d6cdb0346a13960c96
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

Read the full coverage report