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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
Renal guidance: Boxed Warning, sections 2.1 and 8.6
Limits that apply to these rows
The upper clearance restriction applies to AF. DVT/PE has separate eligibility, initial parenteral therapy, weight and interacting-drug criteria.
Nonvalvular atrial fibrillation in adults
Cockcroft-Gault CrCl (mL/min)
Edoxaban oral regimen
>95
Do not use for NVAF
>50 to 95
60 mg once daily
15 to 50
30 mg once daily
<15
Not recommended
Read the retained text before reformatting
For adult nonvalvular AF, do not use edoxaban above CrCl 95 mL/min. Give 60 mg once daily at CrCl above 50 through 95, or 30 mg once daily at 15-50 mL/min. Use below 15 is not recommended. The upper clearance restriction applies to AF. DVT/PE has separate eligibility, initial parenteral therapy, weight and interacting-drug criteria.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
