Edoxaban tablets (Savaysa, adults) | GlobalRPh Renal Dosing Master

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Official source

Edoxaban tablets (Savaysa, adults) - selected U.S. label sections

Product / population: Adult SAVAYSA oral tablets; atrial fibrillation and venous thromboembolism are distinct indications.
Renal measure: Cockcroft-Gault creatinine clearance in mL/min

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Nonvalvular atrial fibrillation - renal regimen

Cockcroft-Gault CrCl	Oral regimen
Above 50 through 95 mL/min	60 mg once daily
15 through 50 mL/min	30 mg once daily
Above 95 mL/min	Do not use for NVAF; choose another anticoagulant

The high-clearance restriction reflects reduced efficacy for NVAF and is not a low-renal-function precaution.

DVT or PE - separate dose rule

After 5-10 days of parenteral anticoagulation, the usual labeled dose is 60 mg once daily. Reduce to 30 mg once daily for CrCl 15-50 mL/min, body weight at or below 60 kg, or specified P-gp inhibitors. This summary does not provide an ESRD or dialysis regimen.

Source revision: 10/2023 | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e77d3400-56ad-11e3-949a-0800200c9a66

Scope: Local label summary; independent clinical review pending. Not a two-source validated protocol. GlobalRPh v6.6.

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Official product label

Edoxaban tablets (Savaysa, adults) - selected U.S. label sections

Adult SAVAYSA oral tablets; atrial fibrillation and venous thromboembolism are distinct indications.

Renal method: Cockcroft-Gault creatinine clearance in mL/min
Retrieved: 2026-09-05

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

Official source

Edoxaban tablets (Savaysa, adults) - selected U.S. label sections

Adult SAVAYSA oral tablets; atrial fibrillation and venous thromboembolism are distinct indications.

Method: Cockcroft-Gault creatinine clearance in mL/min

Nonvalvular atrial fibrillation - renal regimen Read this complete source summary

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Original content / product scope Edoxaban tablets (Savaysa, adults) - selected U.S. label sections

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Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e77d3400-56ad-11e3-949a-0800200c9a66

Product and population scope

Adult SAVAYSA oral tablets; atrial fibrillation and venous thromboembolism are distinct indications.

RDM32-edoxaban-savaysa-scope · Source section: Editorial scope for the selected U.S. labelRenal section finder

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FDA / DailyMed dosing and renal information

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Edoxaban tablets (Savaysa, adults) - selected U.S. label sections

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U.S. product labeling / DailyMed · Adult SAVAYSA oral tablets; atrial fibrillation and venous thromboembolism are distinct indications.

Renal method: Cockcroft-Gault creatinine clearance in mL/min
Source date: 10/2023
Retrieved: 2026-09-05

Local label summary; independent clinical review pending. Not a two-source validated protocol.

Nonvalvular atrial fibrillation - renal regimen

Cockcroft-Gault CrCl	Oral regimen
Above 50 through 95 mL/min	60 mg once daily
15 through 50 mL/min	30 mg once daily
Above 95 mL/min	Do not use for NVAF; choose another anticoagulant

The high-clearance restriction reflects reduced efficacy for NVAF and is not a low-renal-function precaution.

RDM32-edoxaban-savaysa-1 · Source locator: Boxed warning; 2.1; 5.1

DVT or PE - separate dose rule

RDM32-edoxaban-savaysa-2 · Source locator: 2.2; 8.6

Source-specific limits

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Source identity and provenance

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e77d3400-56ad-11e3-949a-0800200c9a66
Retrieved: 2026-09-05
DailyMed Set ID: e77d3400-56ad-11e3-949a-0800200c9a66
Label revision: 10/2023
Renal-function method: Cockcroft-Gault creatinine clearance in mL/min
Source date/version: 10/2023
Hash meaning: SHA-256 identifies this local summary, not original SPL XML or a label PDF.
Local summary SHA-256: 43765761a6144ca8ad5a6cf352668a1b8b4f189690300683e75553e3add1e97f

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e77d3400-56ad-11e3-949a-0800200c9a66
Source retrieval: 2026-09-05. This is not the source publication or label revision date.
Original source type: multisource addition
Local text SHA-256: 8fcd50e6afb0632bcf10e4a3e882f62b3daedf4b0a52b6cbc23d84294d3a72a0
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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