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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
Check source scope before reading a dose
SAVELLA: selected RX renal passage
Product / population
Adult oral SAVELLA for fibromyalgia; not levomilnacipran extended-release.
Renal method
Estimated CrCl, mL/min; severe 5-29
Source revision
Revision date not established in reviewed mirror passage.
Retrieved
2026-11-07
Local review status
Selected sections checked against the identified source; not a complete monograph or independent clinician approval.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
SAVELLA: source applicability and renal evidence limits
Use the intact renal-dosing section, not the malformed moderate-renal PK range in the mirror. Reduced maintenance and initial titration are separate instructions.
What to reconcile: Do not skip titration or abruptly stop extended treatment.
GlobalRPh RX List / label mirror · Adult oral SAVELLA for fibromyalgia; not levomilnacipran extended-release.
Renal method: Estimated CrCl, mL/min; severe 5-29 Source date: Revision date not established in reviewed mirror passage. Retrieved: 2026-11-07
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Before using this finding
ESRD: not recommended. Mild: no adjustment; moderate: caution.
Dialysis evidence: No dialysis regimen established in selected content
Selected sections checked against the identified source; not a complete monograph or independent clinician approval.
Section 2.2; discontinuation context
The intact renal dosing section reports reduced maintenance at CrCl 5-29, a response-dependent increase, and ESRD avoidance. A malformed moderate-renal range in the PK paragraph was excluded from numerical interpretation.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
