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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
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Requip XL - labeled renal guidance
Product / population
Ropinirole (Requip XL), adult extended-release tablets for Parkinson disease
Renal method
Creatinine clearance (CrCl), mL/min; use the product-specific calculation
All record notes are retained here, including notes about sources not selected in this review.
ER Parkinson regimen is not the IR RLS schedule
The official ER source has a once-daily dialysis starting regimen. Its maximum does not make IR and ER starting doses or indications interchangeable.
What to reconcile: Confirm exact release formulation and indication. The failed REQUIP XL mirror has not been recovered by adding an official generic label.
At CrCl 30-50 mL/min there is no renal adjustment. With ESRD on regular HD, start at 2 mg once daily and limit the total to 18 mg/day. A post-HD supplement is unnecessary. Severe renal impairment without regular dialysis was not studied. Verify XL and Parkinson disease indication.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
