GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Buspirone hydrochloride tablets (adults)

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Check source scope before reading a dose

Buspirone hydrochloride tablets (adults) - selected U.S. labeling

Product / population
Adult anxiety treatment with oral buspirone hydrochloride tablets; severe renal impairment requires special avoidance review.
Renal method
Indexed ClCr in the pharmacokinetic study; severe-impairment warning is qualitative.
Source revision
Label revision date not separately recorded; retrieval date is not the revision date.
Retrieved
2026-09-05
Local review status
Selected dosing/renal sections read; concise local summary, not full prescribing information.
Official

Buspirone hydrochloride tablets (adults) - selected U.S. labeling

Open original reference

U.S. product labeling / DailyMed · Adult anxiety treatment with oral buspirone hydrochloride tablets; severe renal impairment requires special avoidance review.

Renal method: Indexed ClCr in the pharmacokinetic study; severe-impairment warning is qualitative.
Source date: Label revision date not separately recorded; retrieval date is not the revision date.
Retrieved: 2026-09-05

Selected dosing/renal sections read; concise local summary, not full prescribing information.

Labeled basic dosing

Start 7.5 mg orally twice daily. If needed, increase total daily dosing by 5 mg at 2-3 day intervals; maximum 60 mg/day. Take consistently with respect to food.

RDM31-buspirone-label-dose · Source locator: Dosage and Administration

Renal information and dialysis

The label does not recommend use in severe renal impairment. Exposure was approximately fourfold greater in a study spanning ClCr 10-70 mL/min/1.73 m2. No validated numeric renal-dose algorithm is provided; dialysis removal is undetermined.

RDM31-buspirone-label-renal · Source locator: Clinical Pharmacology: Renal Impairment; Precautions; Overdosage

Selected warnings and limits

Review CYP3A4 interactions and serotonin syndrome. MAOI antidepressants require separation; do not start with linezolid or intravenous methylene blue.

RDM31-buspirone-label-limits · Source locator: Contraindications; Drug Interactions

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff02c7cb-f96a-4a3b-99a2-812cd78b345c
Retrieved
2026-09-05
DailyMed Set ID
ff02c7cb-f96a-4a3b-99a2-812cd78b345c
Renal-function method
Indexed ClCr in the pharmacokinetic study; severe-impairment warning is qualitative.
Source date/version
Label revision date not separately recorded; retrieval date is not the revision date.
Hash meaning
SHA-256 identifies this local summary, not original SPL XML or label PDF.
Local summary SHA-256
ff7b4897bfac437802bd72d244654a04f8094d1c618c97e05127517de35c04e6

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=buspirone&s1=RDM31-label-buspirone&h1=bd2458d75f0cd9a1feb387ca81f687a1898b9be6a265459185711bf71a540d2a