GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Buspirone hydrochloride tablets (adults)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons

BuSpar

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Official source

Buspirone hydrochloride tablets (adults) - selected U.S. labeling

Product / population
Adult anxiety treatment with oral buspirone hydrochloride tablets; severe renal impairment requires special avoidance review.
Renal measure
Indexed ClCr in the pharmacokinetic study; severe-impairment warning is qualitative.
Labeled basic dosing

Start 7.5 mg orally twice daily. If needed, increase total daily dosing by 5 mg at 2-3 day intervals; maximum 60 mg/day. Take consistently with respect to food.

Renal information and dialysis

The label does not recommend use in severe renal impairment. Exposure was approximately fourfold greater in a study spanning ClCr 10-70 mL/min/1.73 m2. No validated numeric renal-dose algorithm is provided; dialysis removal is undetermined.

Selected warnings and limits

Review CYP3A4 interactions and serotonin syndrome. MAOI antidepressants require separation; do not start with linezolid or intravenous methylene blue.

Source revision: Label revision date not separately recorded; retrieval date is not the revision date. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff02c7cb-f96a-4a3b-99a2-812cd78b345c

Scope: Selected dosing/renal sections read; concise local summary, not full prescribing information. GlobalRPh v6.6.

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Evidence sources and renal implications

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Official product label

Buspirone hydrochloride tablets (adults) - selected U.S. labeling

Adult anxiety treatment with oral buspirone hydrochloride tablets; severe renal impairment requires special avoidance review.

Renal method: Indexed ClCr in the pharmacokinetic study; severe-impairment warning is qualitative.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
Handbook

Renal Drug Handbook, fifth edition - Buspirone hydrochloride tablets (adults)

Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Official source

Buspirone hydrochloride tablets (adults) - selected U.S. labeling

Adult anxiety treatment with oral buspirone hydrochloride tablets; severe renal impairment requires special avoidance review.

Method: Indexed ClCr in the pharmacokinetic study; severe-impairment warning is qualitative.

Renal information and dialysisRead this complete source summary
Handbook source

Renal Drug Handbook, fifth edition - Buspirone hydrochloride tablets (adults)

Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.

Historical renal and dialysis observationsRead this complete source summary

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Original content / product scopeBuspirone hydrochloride tablets (adults) - selected U.S. labelingRenal Drug Handbook, fifth edition - Buspirone hydrochloride tablets (adults)
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff02c7cb-f96a-4a3b-99a2-812cd78b345c

Product and population scope

Adult anxiety treatment with oral buspirone hydrochloride tablets; severe renal impairment requires special avoidance review.

RDM31-buspirone-scope · Source section: Editorial scope tied to selected U.S. labelRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Buspirone hydrochloride tablets (adults) - selected U.S. labeling

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U.S. product labeling / DailyMed · Adult anxiety treatment with oral buspirone hydrochloride tablets; severe renal impairment requires special avoidance review.

Renal method: Indexed ClCr in the pharmacokinetic study; severe-impairment warning is qualitative.
Source date: Label revision date not separately recorded; retrieval date is not the revision date.
Retrieved: 2026-09-05

Selected dosing/renal sections read; concise local summary, not full prescribing information.

Labeled basic dosing

Start 7.5 mg orally twice daily. If needed, increase total daily dosing by 5 mg at 2-3 day intervals; maximum 60 mg/day. Take consistently with respect to food.

RDM31-buspirone-label-dose · Source locator: Dosage and Administration

Renal information and dialysis

The label does not recommend use in severe renal impairment. Exposure was approximately fourfold greater in a study spanning ClCr 10-70 mL/min/1.73 m2. No validated numeric renal-dose algorithm is provided; dialysis removal is undetermined.

RDM31-buspirone-label-renal · Source locator: Clinical Pharmacology: Renal Impairment; Precautions; Overdosage

Selected warnings and limits

Review CYP3A4 interactions and serotonin syndrome. MAOI antidepressants require separation; do not start with linezolid or intravenous methylene blue.

RDM31-buspirone-label-limits · Source locator: Contraindications; Drug Interactions

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff02c7cb-f96a-4a3b-99a2-812cd78b345c
Retrieved
2026-09-05
DailyMed Set ID
ff02c7cb-f96a-4a3b-99a2-812cd78b345c
Renal-function method
Indexed ClCr in the pharmacokinetic study; severe-impairment warning is qualitative.
Source date/version
Label revision date not separately recorded; retrieval date is not the revision date.
Hash meaning
SHA-256 identifies this local summary, not original SPL XML or label PDF.
Local summary SHA-256
ff7b4897bfac437802bd72d244654a04f8094d1c618c97e05127517de35c04e6
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, fifth edition - Buspirone hydrochloride tablets (adults)

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UK Renal Pharmacy Group / CRC Press · Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source date: Fifth edition, 2019
Retrieved: 2026-09-05

Historical source, separately displayed. Renal tables were read with page-image inspection.

Historical renal and dialysis observations

The book advises a low starting dose twice daily at 20-50 and 10-20 mL/min. Its below-10 table suggests a 25-50% reduction for anuria, but its own subsequent comments say severe-renal use is not recommended because active metabolites may accumulate.

RDM31-buspirone-book · Source locator: Dose in renal impairment; renal replacement therapies; Other information

Source-specific limits

The book contains an internal conflict. The anuric reduction is historical, not evidence of safety or a replacement for the U.S. label's non-recommendation.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
Printed page(s) 150; PDF page(s) 169
Renal-function method
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source date/version
Fifth edition, 2019
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff02c7cb-f96a-4a3b-99a2-812cd78b345c
Hash meaning
SHA-256 identifies the local paraphrase; the source PDF is not redistributed.
Local summary SHA-256
4613ebf5907d2ce0868c8a33b75f73e7576e645fab31a672a456a1b7fa3f7539

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ff02c7cb-f96a-4a3b-99a2-812cd78b345c
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
c885934c52facf2a76f3abfaedd347abf538b9962bffd14d2226dc71c737b257
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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