GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Hydroxyurea capsules (Hydrea, oncology)

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

Selecting here opens the current stored cards. The pinned link below records their fingerprints. Do not enter patient information in links or searches.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Check source scope before reading a dose

Hydroxyurea capsules (Hydrea, oncology) - selected U.S. label sections

Product / population
HYDREA oncology capsules only. Not a SIKLOS or DROXIA sickle-cell dosing protocol.
Renal method
Creatinine clearance in mL/min
Source revision
Revision not captured; retrieval date is not the revision date.
Retrieved
2026-09-05
Local review status
Local label summary; independent clinical review pending. Not a two-source validated protocol.
Official

Hydroxyurea capsules (Hydrea, oncology) - selected U.S. label sections

Open original reference

U.S. product labeling / DailyMed · HYDREA oncology capsules only. Not a SIKLOS or DROXIA sickle-cell dosing protocol.

Renal method: Creatinine clearance in mL/min
Source date: Revision not captured; retrieval date is not the revision date.
Retrieved: 2026-09-05

Local label summary; independent clinical review pending. Not a two-source validated protocol.

Initial renal dosing

CrClInitial oral dose
60 mL/min or higher15 mg/kg once daily
Below 60 mL/min or ESRD7.5 mg/kg once daily

This is a 50% initial-dose reduction. On hemodialysis days, give the dose after dialysis.

RDM32-hydroxyurea-hydrea-1 · Source locator: 2.3; 8.6

Monitoring and scope

Monitor hematologic parameters closely and adjust treatment for marrow suppression. The renal table does not replace indication-specific duration, weight selection or subsequent toxicity adjustments in the full label.

RDM32-hydroxyurea-hydrea-2 · Source locator: 2; 5.1; 8.6

Source-specific limits

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6053c775-68de-45e4-9af9-33b18fd0e140
Retrieved
2026-09-05
DailyMed Set ID
6053c775-68de-45e4-9af9-33b18fd0e140
Renal-function method
Creatinine clearance in mL/min
Source date/version
Revision not captured; retrieval date is not the revision date.
Hash meaning
SHA-256 identifies this local summary, not original SPL XML or a label PDF.
Local summary SHA-256
58d28528151640127c107cb2b125c6e34fffcea43bf92bdff61c77332d858822

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=hydroxyurea-hydrea&s1=RDM32-label-hydroxyurea-hydrea&h1=724a5434a480ac1941586ebf55faeb8b899155012439e7412443a610170601ad