GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Zuranolone capsules (Zurzuvae)

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

Selecting here opens the current stored cards. The pinned link below records their fingerprints. Do not enter patient information in links or searches.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

Copy is optional; the link can be selected and copied manually. No patient data or dose decision is collected.

Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Check source scope before reading a dose

Zuranolone capsules (Zurzuvae) - selected U.S. label sections

Product / population
Adult ZURZUVAE oral capsules for postpartum depression.
Renal method
eGFR in mL/min/1.73 m2
Source revision
Revision not captured; retrieval date is not the revision date.
Retrieved
2026-09-05
Local review status
Local label summary; independent clinical review pending. Not a two-source validated protocol.
Official

Zuranolone capsules (Zurzuvae) - selected U.S. label sections

Open original reference

U.S. product labeling / DailyMed · Adult ZURZUVAE oral capsules for postpartum depression.

Renal method: eGFR in mL/min/1.73 m2
Source date: Revision not captured; retrieval date is not the revision date.
Retrieved: 2026-09-05

Local label summary; independent clinical review pending. Not a two-source validated protocol.

Renal dose modification

For moderate or severe impairment with eGFR below 60, the recommended dose is 30 mg once each evening for 14 days. The threshold is below 60, not only below 30.

RDM32-zuranolone-zurzuvae-1 · Source locator: 2.4

Course and safety boundary

This is a finite treatment course, not indefinite nightly dosing. Review the boxed warning, administration requirements and CNS-depressant interactions before use. No dialysis regimen is inferred here.

RDM32-zuranolone-zurzuvae-2 · Source locator: Boxed warning; 2; 5; 7

Source-specific limits

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f18e53b0-d0bb-422d-8de7-ab64b7292b29
Retrieved
2026-09-05
DailyMed Set ID
f18e53b0-d0bb-422d-8de7-ab64b7292b29
Renal-function method
eGFR in mL/min/1.73 m2
Source date/version
Revision not captured; retrieval date is not the revision date.
Hash meaning
SHA-256 identifies this local summary, not original SPL XML or a label PDF.
Local summary SHA-256
e1430b3bb75f5a98d36fcbda14db2e47aadb73dc5264ff8b034ff8a1d8e048ac

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=zuranolone-zurzuvae&s1=RDM32-label-zuranolone-zurzuvae&h1=65f17904e670ec3dce0014e3a3f16ece0a949077bb31ee0bd61f8897f56b16a5