Zuranolone capsules (Zurzuvae) | GlobalRPh Renal Dosing Master

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Official source

Zuranolone capsules (Zurzuvae) - selected U.S. label sections

Product / population: Adult ZURZUVAE oral capsules for postpartum depression.
Renal measure: eGFR in mL/min/1.73 m2

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Renal dose modification

For moderate or severe impairment with eGFR below 60, the recommended dose is 30 mg once each evening for 14 days. The threshold is below 60, not only below 30.

Course and safety boundary

This is a finite treatment course, not indefinite nightly dosing. Review the boxed warning, administration requirements and CNS-depressant interactions before use. No dialysis regimen is inferred here.

Source revision: Revision not captured; retrieval date is not the revision date. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f18e53b0-d0bb-422d-8de7-ab64b7292b29

Scope: Local label summary; independent clinical review pending. Not a two-source validated protocol. GlobalRPh v6.6.

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Official product label

Zuranolone capsules (Zurzuvae) - selected U.S. label sections

Adult ZURZUVAE oral capsules for postpartum depression.

Renal method: eGFR in mL/min/1.73 m2
Retrieved: 2026-09-05

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

Official source

Zuranolone capsules (Zurzuvae) - selected U.S. label sections

Adult ZURZUVAE oral capsules for postpartum depression.

Method: eGFR in mL/min/1.73 m2

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Original content / product scope Zuranolone capsules (Zurzuvae) - selected U.S. label sections

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f18e53b0-d0bb-422d-8de7-ab64b7292b29

Product and population scope

Adult ZURZUVAE oral capsules for postpartum depression.

RDM32-zuranolone-zurzuvae-scope · Source section: Editorial scope for the selected U.S. labelRenal section finder

Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

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Zuranolone capsules (Zurzuvae) - selected U.S. label sections

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U.S. product labeling / DailyMed · Adult ZURZUVAE oral capsules for postpartum depression.

Renal method: eGFR in mL/min/1.73 m2
Source date: Revision not captured; retrieval date is not the revision date.
Retrieved: 2026-09-05

Local label summary; independent clinical review pending. Not a two-source validated protocol.

Renal dose modification

For moderate or severe impairment with eGFR below 60, the recommended dose is 30 mg once each evening for 14 days. The threshold is below 60, not only below 30.

RDM32-zuranolone-zurzuvae-1 · Source locator: 2.4

Course and safety boundary

RDM32-zuranolone-zurzuvae-2 · Source locator: Boxed warning; 2; 5; 7

Source-specific limits

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Source identity and provenance

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f18e53b0-d0bb-422d-8de7-ab64b7292b29
Retrieved: 2026-09-05
DailyMed Set ID: f18e53b0-d0bb-422d-8de7-ab64b7292b29
Renal-function method: eGFR in mL/min/1.73 m2
Source date/version: Revision not captured; retrieval date is not the revision date.
Hash meaning: SHA-256 identifies this local summary, not original SPL XML or a label PDF.
Local summary SHA-256: e1430b3bb75f5a98d36fcbda14db2e47aadb73dc5264ff8b034ff8a1d8e048ac

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f18e53b0-d0bb-422d-8de7-ab64b7292b29
Source retrieval: 2026-09-05. This is not the source publication or label revision date.
Original source type: multisource addition
Local text SHA-256: 551dfedc4bbd37e040044128aadf406293dae16f3dc9b5fd5983d6e8e2d9656b
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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