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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
All doses are total piperacillin plus tazobactam. The 30-minute source regimen is not an extended-infusion university regimen. The original PD summary and indication-specific CAPD table differ.
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UCSF piperacillin/tazobactam - extended infusion and dialysis
Product / population
UCSF adult institutional policy; total combination grams. Exclusions and dialysis setting must match.
Renal method
Adult CrCl, mL/min; intermittent versus continuous HD.
Source revision
Source revision date not established in selected retrieval.
Retrieved
2026-09-07
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Three-hour and four-hour institutional protocols are not interchangeable
Sinai Health and UCSF differ in infusion duration, initial-to-maintenance timing, renal intervals and dialysis regimens. These are separate local pathways, not duplicate confirmations of one universal dose.
What to reconcile: Choose an approved institution-specific pathway with infection, susceptibility, dialysis settings and IV access documented. Do not pair one source's dose with the other's interval or loading sequence.
The RX short-infusion table separates nosocomial pneumonia and other indications and specifies an HD supplement. UCSF lists a different all-infection intermittent-HD schedule.
What to reconcile: Keep the chosen regimen, infusion duration, indication and dialysis assumptions intact. Do not add the label supplement automatically to an institution's different regimen. Exactly 20 is also unassigned by UCSF's printed greater-than/less-than headings.
UCSF Infectious Diseases Management Program · UCSF adult institutional policy; total combination grams. Exclusions and dialysis setting must match.
Renal method: Adult CrCl, mL/min; intermittent versus continuous HD. Source date: Source revision date not established in selected retrieval. Retrieved: 2026-09-07
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
For eligible adults with CrCl above 20 mL/min, UCSF uses 4.5 g over 30 minutes once, followed immediately by 4.5 g infused over four hours every eight hours. Below 20, use its short-infusion pathway; exactly 20 is not assigned by the printed greater-than/less-than headings. Exclusions include resistant/intermediate organisms, cystic fibrosis, peri-procedural areas and inadequate IV access. UCSF intermittent HD dosing is 2.25 g every eight hours over 30 minutes; continuous HD uses the extended-infusion load/maintenance strategy. These institutional schedules differ from both label short infusions and Sinai Health's three-hour policy. ZSFG has a different default infusion policy even on this UCSF page.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.