GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Lamivudine and lamivudine/zidovudine

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

HIV and hepatitis-B lamivudine dosing differ. The single-agent and fixed-combination records must not be interchanged.

The preserved source page includes lamivudine and a zidovudine combination. Newly added adult single-agent and pediatric guidance are explicitly scoped; do not transfer single-agent dose changes to the fixed combination. NIH and the Southern African society use different renal approaches and alternatives.

Check source scope before reading a dose

Southern African HIV Clinicians Society - lamivudine renal protocol

Product / population
Adults with HIV; non-U.S. society protocol for single-agent lamivudine
Renal method
Indexed eGFR mL/min/1.73 m2 (CKD-EPI preference stated)
Source revision
Revision date not stated in the reviewed page.
Retrieved
2026-09-05
Local review status
Locally included source-specific summary. Regimen differences are not automatically resolved.
Professional

Southern African HIV Clinicians Society - lamivudine renal protocol

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Southern African HIV Clinicians Society · Adults with HIV; non-U.S. society protocol for single-agent lamivudine

Renal method: Indexed eGFR mL/min/1.73 m2 (CKD-EPI preference stated)
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Single-agent lamivudine, in the society's CKD table: indexed eGFR 30-50 mL/min/1.73 m2, unchanged; 15-30, 150 mg daily; <15, 50 mg daily. HD or PD: first 50 mg, then 25 mg daily; give ART after HD. The adjacent bands overlap at 30; confirm the intended boundary locally.

This non-U.S. professional protocol uses indexed eGFR and differs from the NIH label-dose options at some low-clearance bands. Lamivudine is a U.S.-labeled ingredient, but this is not U.S. FDA dosing. It does not apply to fixed-dose lamivudine/zidovudine.

RDM30-103-lamivudine-lamivudineazt-1 · Source locator: Southern African HIV Clinicians Society - lamivudine renal protocol; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://www.sahivsoc.org/Guidelines/Module21
Retrieved
2026-09-05
Renal-function method
Indexed eGFR mL/min/1.73 m2 (CKD-EPI preference stated)
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
9d3b07e3c2827b16ad323a665baa0fd13fbf8468f59f9d5fff4396d6afe1183d

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=lamivudine-lamivudineazt&s1=RDM30-103-lamivudine-lamivudineazt&h1=3eba6acd1b4dc3f3a3785ec633224718772e3e081c7e07d0c50abe546f346302