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Aldactone - labeled renal guidance
Product / population
Spironolactone (Aldactone), adult oral tablets for heart failure
Renal method
Indexed GFR/eGFR, mL/min/1.73 m2
Source revision
DailyMed SPL version 25, effective 2025-11-28; posted Dec 01, 2025
For heart failure, at eGFR 30-50 consider starting at 25 mg every other day because of hyperkalemia risk. At eGFR >50 and potassium <=5 mEq/L, the initial dose is 25 mg daily. Check potassium within one week of starting or titrating and regularly thereafter. Verify baseline potassium, volume status and interacting drugs.
RDM73-aldactone-official-1 · Source locator: Renal guidance: 2.2 and 5.1
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
