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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
Check source scope before reading a dose
Lynparza - labeled renal guidance
Product / population
Olaparib (Lynparza), adult oral tablets
Renal method
Cockcroft-Gault creatinine clearance, mL/min
Source revision
DailyMed SPL version 38, effective 2025-07-10; posted Jul 25, 2025
All record notes are retained here, including notes about sources not selected in this review.
Lynparza - product and source limitations
The U.S. label uses CrCl in mL/min. eviQ protocol 3737 uses indexed eGFR and leaves exactly 30 outside its printed bands. Use the renal estimate specified by the selected source.
What to reconcile: The U.S. label uses CrCl in mL/min. eviQ protocol 3737 uses indexed eGFR and leaves exactly 30 outside its printed bands. Use the renal estimate specified by the selected source.
At CrCl 31-50 mL/min, use 200 mg twice daily. At 51-80, no renal dose change is recommended. The selected label has no data for CrCl <=30 mL/min, including end-stage disease. Check interaction-related modifications separately.
RDM73-lynparza-official-1 · Source locator: Renal guidance: 2.5 and 8.6
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh Renal Dosing Master v7.4. Review the retrieval and revision dates attached to each source. Selecting a reference does not imply clinical verification.
