GlobalRPh Renal Dosing Masterv6.6
Source review / handoff

Cephalexin

One or two intact local summaries. No averaged regimen, patient-specific dose or automatic source preference.

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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.

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Clinical context remains essential

Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.

Check source scope before reading a dose

GlobalRPh RX List - Keflex

Product / population
Adults and patients at least 15 years old; oral cephalexin label table.
Renal method
CrCl, mL/min.
Source revision
Revised October 2015
Retrieved
2026-09-07
Local review status
Locally imported selected source sections; independent clinical review pending. Not a complete prescribing monograph.

Documented differences and cautions on this drug

All record notes are retained here, including notes about sources not selected in this review.

Label maximum differs from institution-specific bacteremia dosing

The KEFLEX renal table caps the daily dose in moderate impairment. UCSF uses a different high-dose strategy for selected gram-negative bloodstream infection; Stanford also has a distinct HD regimen.

What to reconcile: The indication and regimen must stay together. Do not average the doses or relabel the bloodstream-infection schedule as a general renal dose.

Source difference identified; final patient-specific adjudication required.

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Label daily cap versus indication-specific institutional bloodstream doses

KEFLEX limits total daily dose to 1 g at CrCl 30-59 and has insufficient HD adjustment information. UCSF uses higher selected Gram-negative bloodstream-infection doses and supplies an intermittent-HD row.

What to reconcile: Assess infection eligibility, organism susceptibility, patient setting and institutional policy. Keep the complete institutional regimen separate from the label; do not transfer the bloodstream schedule to routine cystitis or children.

Source-specific interpretation; independent clinician adjudication pending.

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Rxlist

GlobalRPh RX List - Keflex

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GlobalRPh-hosted RX List · Adults and patients at least 15 years old; oral cephalexin label table.

Renal method: CrCl, mL/min.
Source date: Revised October 2015
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Locally imported selected source sections; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Renal rangeSource dose recommendation
At least 60No adjustment
30-59No adjustment, but maximum total daily dose 1 g
15-29250 mg every 8 or 12 hours
5-14, not yet on dialysis250 mg every 24 hours
1-4, not yet on dialysis250 mg every 48 or 60 hours

The source states that information is insufficient to recommend a hemodialysis adjustment. This label-era table is kept separate from institution-specific high-dose infection regimens.

RDM33-rxlist-cephalexin-C1 · Source locator: Dosage adjustment in renal impairment, Table 1.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/keflex-drug/
Retrieved
2026-09-07
Renal-function method
CrCl, mL/min.
Source date/version
Revised October 2015
Hash meaning
SHA-256 of the local authored summary only; original HTML/PDF/SPL bytes are not bundled or hashed.
Local summary SHA-256
a71459cf6fb974422f397012732d6a2c426bf5c695e9fb5531dc5ffadb02e1bd

Document the clinical decision separately

This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.

GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.

Pinned reference: https://globalrph.com/blogCalcs/renal-dosing-master/compare.php?id=cephalexin&s1=RDM33-rxlist-cephalexin&h1=290a34fe40ef7e83dc7202d891da93baf84ac058b60aa1ba185f779fc817620d