GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Cephalexin

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug6 sources available - open source summaries, references and comparisons
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Renal guidance at a glance

Cautions / source differences (2)

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2 additional source qualifications - review before use
Label maximum differs from institution-specific bacteremia dosing

The KEFLEX renal table caps the daily dose in moderate impairment. UCSF uses a different high-dose strategy for selected gram-negative bloodstream infection; Stanford also has a distinct HD regimen.

Before applying: The indication and regimen must stay together. Do not average the doses or relabel the bloodstream-infection schedule as a general renal dose.

Label daily cap versus indication-specific institutional bloodstream doses

KEFLEX limits total daily dose to 1 g at CrCl 30-59 and has insufficient HD adjustment information. UCSF uses higher selected Gram-negative bloodstream-infection doses and supplies an intermittent-HD row.

Before applying: Assess infection eligibility, organism susceptibility, patient setting and institutional policy. Keep the complete institutional regimen separate from the label; do not transfer the bloodstream schedule to routine cystitis or children.

Also check: Label maximum differs from institution-specific bacteremia dosing; Label daily cap versus indication-specific institutional bloodstream doses

Rxlist source

GlobalRPh RX List - KEFLEX

Product / population
Oral KEFLEX; renal table applies to adults and pediatric patients at least 15 years old.
Renal measure
CrCl mL/min; no specified estimator in selected table.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

CrCl >=60: no adjustment. CrCl 30-59: maximum total daily dose 1 g. CrCl 15-29: 250 mg every 8 or 12 hours. CrCl 5-14, not on dialysis: 250 mg every 24 hours. CrCl 1-4, not on dialysis: 250 mg every 48 or 60 hours. The source has insufficient information to recommend hemodialysis adjustment. Do not apply this adult/adolescent table to younger children or replace its unusual 60-hour option with an invented interval.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/keflex-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - Keflex

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adults and patients at least 15 years old; oral cephalexin label table.

Renal method: CrCl, mL/min.
Retrieved: 2026-09-07

Read local renal resultOpen original reference
GlobalRPh RX List

GlobalRPh RX List - KEFLEX

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Oral KEFLEX; renal table applies to adults and pediatric patients at least 15 years old.

Renal method: CrCl mL/min; no specified estimator in selected table.
Retrieved: 2026-09-07

Read local renal resultOpen original reference
Professional guidance

UCSF - cephalexin: bacteremia and IHD

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

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Professional guidance

Stanford - cephalexin selected renal/HD rows

Adult oral cephalexin; selected rows from institutional antimicrobial guide.

Renal method: CrCl, mL/min; intermittent HD assumes three sessions weekly.
Retrieved: 2026-09-07

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Professional guidance

UCSF cephalexin - selected bloodstream-infection and dialysis rows

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult institutional oral therapy for selected gram-negative bloodstream infection; eligibility not established by the renal table alone.

Renal method: Renal table mL/min; institutional CrCl context; intermittent versus continuous HD kept separate.
Retrieved: 2026-09-07

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Source differences and product cautions

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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

setting specific

Label maximum differs from institution-specific bacteremia dosing

The KEFLEX renal table caps the daily dose in moderate impairment. UCSF uses a different high-dose strategy for selected gram-negative bloodstream infection; Stanford also has a distinct HD regimen.

How to use this: The indication and regimen must stay together. Do not average the doses or relabel the bloodstream-infection schedule as a general renal dose.

GlobalRPh RX List - KeflexUCSF - cephalexin: bacteremia and IHDStanford - cephalexin selected renal/HD rows

Source difference identified; final patient-specific adjudication required.

professional protocol difference

Label daily cap versus indication-specific institutional bloodstream doses

KEFLEX limits total daily dose to 1 g at CrCl 30-59 and has insufficient HD adjustment information. UCSF uses higher selected Gram-negative bloodstream-infection doses and supplies an intermittent-HD row.

How to use this: Assess infection eligibility, organism susceptibility, patient setting and institutional policy. Keep the complete institutional regimen separate from the label; do not transfer the bloodstream schedule to routine cystitis or children.

GlobalRPh RX List - KEFLEXUCSF cephalexin - selected bloodstream-infection and dialysis rows

Source-specific interpretation; independent clinician adjudication pending.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.
Professional source

UCSF cephalexin - selected bloodstream-infection and dialysis rows

Adult institutional oral therapy for selected gram-negative bloodstream infection; eligibility not established by the renal table alone.

Method: Renal table mL/min; institutional CrCl context; intermittent versus continuous HD kept separate.

Renal dosing, restrictions and evidence limitsRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scopeGlobalRPh RX List - KeflexGlobalRPh RX List - KEFLEXUCSF - cephalexin: bacteremia and IHDStanford - cephalexin selected renal/HD rowsUCSF cephalexin - selected bloodstream-infection and dialysis rows
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/cephalexin/

Usual Dosing (Adults)

Adult dosage ranges from 1 to 4 g daily in divided doses. Usual: 250 mg every 6 hours. For streptococcal pharyngitis, skin/skin structure infections, and uncomplicated cystitis in patients over 15 years, 500 mg every 12 hours may be used. Cystitis therapy should be continued for 7 to 14 days. More severe infections or less susceptible organisms may require larger doses. If more than 4 g/day is required, consider a parenteral cephalosporin.

Pediatric patients: oral suspension may be more appropriate for some doses. Usual total daily dose 25 to 50 mg/kg in divided doses. For streptococcal pharyngitis in patients over 1 year and skin/skin structure infections, the daily dose may be divided every 12 hours. Double the dosage for severe infections. Otitis media: 75 to 100 mg/kg/day in 4 divided doses. Treat beta-hemolytic streptococcal infections for at least 10 days.

GRPH-cephalexin-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl >30 mL/min: no changes; 10 to 30: 250 to 500 mg every 8 to 12 hours; <10: 250 to 500 mg every 12 to 24 hours.

GRPH-cephalexin-02 · Source section: Renal DosingRenal section finder

Hemodialysis

250 to 500 mg every 12 to 24 hours; give after dialysis on dialysis days.

GRPH-cephalexin-03 · Source section: HemodialysisRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - Keflex

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GlobalRPh-hosted RX List · Adults and patients at least 15 years old; oral cephalexin label table.

Renal method: CrCl, mL/min.
Source date: Revised October 2015
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Locally imported selected source sections; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Renal rangeSource dose recommendation
At least 60No adjustment
30-59No adjustment, but maximum total daily dose 1 g
15-29250 mg every 8 or 12 hours
5-14, not yet on dialysis250 mg every 24 hours
1-4, not yet on dialysis250 mg every 48 or 60 hours

The source states that information is insufficient to recommend a hemodialysis adjustment. This label-era table is kept separate from institution-specific high-dose infection regimens.

RDM33-rxlist-cephalexin-C1 · Source locator: Dosage adjustment in renal impairment, Table 1.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/keflex-drug/
Retrieved
2026-09-07
Renal-function method
CrCl, mL/min.
Source date/version
Revised October 2015
Hash meaning
SHA-256 of the local authored summary only; original HTML/PDF/SPL bytes are not bundled or hashed.
Local summary SHA-256
a71459cf6fb974422f397012732d6a2c426bf5c695e9fb5531dc5ffadb02e1bd
Rxlist

GlobalRPh RX List - KEFLEX

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GlobalRPh-hosted RX List · Oral KEFLEX; renal table applies to adults and pediatric patients at least 15 years old.

Renal method: CrCl mL/min; no specified estimator in selected table.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

CrCl >=60: no adjustment. CrCl 30-59: maximum total daily dose 1 g. CrCl 15-29: 250 mg every 8 or 12 hours. CrCl 5-14, not on dialysis: 250 mg every 24 hours. CrCl 1-4, not on dialysis: 250 mg every 48 or 60 hours. The source has insufficient information to recommend hemodialysis adjustment. Do not apply this adult/adolescent table to younger children or replace its unusual 60-hour option with an invented interval.

RDM42-rxlist-cephalexin-715dcb31c1-C1 · Source locator: Renal dosing Table 1 and footnote

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/keflex-drug/
Retrieved
2026-09-07
Renal-function method
CrCl mL/min; no specified estimator in selected table.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
d7699a9ca792120d70c0586a0d1c55ca853ff030c2513298d79df8126408fc16
Separate professional-source layer

University and professional protocols

Professional

UCSF - cephalexin: bacteremia and IHD

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

For Gram-negative bloodstream infection, the fully populated renal row gives oral doses at renal-function bands >50 / 30-50 / 15-29 / <15 mL/min of 1 g four times daily / 1 g three times daily / 1 g twice daily / 500 mg three times daily.

During IHD, most indications use 250 mg twice daily; uncomplicated cystitis or streptococcal pharyngitis uses 250 mg daily; Gram-negative bloodstream infection uses 500 mg twice daily. The continuous-HD cells provide no regimen.

Other non-dialysis rows have merged or incompletely aligned cells in the retrieved representation. They were not converted into guessed renal-column assignments.

RDM30-013-cephalexin-1 · Source locator: UCSF - cephalexin: bacteremia and IHD; renal/dosing sections and stated qualifiers

Source-specific limits

This imported card covers the unambiguous bacteremia row and IHD rows; it is not the complete set of cephalexin indications.

Source identity and provenance
Source
https://idmp.ucsf.edu/content/cephalexin
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
fc3d135816b24a6b61a8aa6cef3d5a3ba629cce23e047e4107d9aa6dd8d5694e
Professional

Stanford - cephalexin selected renal/HD rows

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Stanford Health Care · Adult oral cephalexin; selected rows from institutional antimicrobial guide.

Renal method: CrCl, mL/min; intermittent HD assumes three sessions weekly.
Source date: ABX Subcommittee approved February 2026 (cover page visually inspected)
Retrieved: 2026-09-07

Locally imported selected source sections; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For CrCl 15-29, the guide lists 250 mg orally every 8-12 hours. For CrCl 5-14, it lists 250 mg every 24 hours. For intermittent HD, it lists 500 mg orally every 24 hours, administered daily but after HD on dialysis days. No CRRT data are listed. Do not substitute the UCSF bacteremia regimen or label regimen without considering indication and institutional policy.

RDM33-professional-cephalexin-C1 · Source locator: PDF page 3, cephalexin row; visual table inspected.

Source identity and provenance
Source family
professional_guidance
Source
https://med.stanford.edu/content/dam/sm/bugsanddrugs/documents/antimicrobial-dosing-protocols/SHC-ABX-Dosing-Guide.pdf
Retrieved
2026-09-07
Renal-function method
CrCl, mL/min; intermittent HD assumes three sessions weekly.
Source date/version
ABX Subcommittee approved February 2026 (cover page visually inspected)
Hash meaning
SHA-256 of the local authored summary only; original HTML/PDF/SPL bytes are not bundled or hashed.
Local summary SHA-256
cb911421c9f565ee99f6208840285d6b35fa672031ffac26f7f5768749eb021a
Professional

UCSF cephalexin - selected bloodstream-infection and dialysis rows

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UCSF Infectious Diseases Management Program · Adult institutional oral therapy for selected gram-negative bloodstream infection; eligibility not established by the renal table alone.

Renal method: Renal table mL/min; institutional CrCl context; intermittent versus continuous HD kept separate.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For the gram-negative bloodstream-infection row: >50 mL/min, 1000 mg four times daily; 30-50, 1000 mg three times daily; 15-29, 1000 mg twice daily; <15, 500 mg three times daily. Intermittent HD: 500 mg twice daily for that indication. Continuous-HD data are absent. These selected institutional doses differ from the KEFLEX label renal cap and are not general-purpose cystitis or pediatric schedules. Two other nondialysis rows rendered with merged cells and were not re-transcribed in this supplement.

RDM42-professional-cephalexin-ddb0ffd100-C1 · Source locator: Adult Gram-Negative Bloodstream Infection row; corresponding dialysis row

Source identity and provenance
Source family
professional_guidance
Source
https://idmp.ucsf.edu/content/cephalexin
Retrieved
2026-09-07
Renal-function method
Renal table mL/min; institutional CrCl context; intermittent versus continuous HD kept separate.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
d62f49a211d2be1339361a5be1ee703df3058ab26be202da4a6dafbe806cecc2

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 2 RX List, 3 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/cephalexin/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
dd825e2f5c1c54e50300b94ee750514602010bc6a2b776372e15cbcbb094e911
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

Read the full coverage report