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Fluoxetine daily capsules (adults) - selected U.S. labeling
Product / population
Adult major depressive disorder; daily oral immediate-release fluoxetine capsules. Excludes weekly delayed-release products and olanzapine combinations.
Renal method
Qualitative renal guidance, supported by a small dialysis pharmacokinetic study; no CrCl dose table.
Source revision
Label revision date not separately recorded; retrieval date is not the revision date.
Retrieved
2026-09-05
Local review status
Selected dosing/renal sections read; concise local summary, not full prescribing information.
Official
Fluoxetine daily capsules (adults) - selected U.S. labeling
U.S. product labeling / DailyMed · Adult major depressive disorder; daily oral immediate-release fluoxetine capsules. Excludes weekly delayed-release products and olanzapine combinations.
Renal method: Qualitative renal guidance, supported by a small dialysis pharmacokinetic study; no CrCl dose table. Source date: Label revision date not separately recorded; retrieval date is not the revision date. Retrieved: 2026-09-05
Selected dosing/renal sections read; concise local summary, not full prescribing information.
Labeled basic dosing
Start 20 mg orally each morning. Consider escalation after several weeks when response is insufficient. Doses above 20 mg/day may be once daily or divided morning/noon; maximum 80 mg/day.
RDM31-fluoxetine-ir-label-dose · Source locator: 2.1 Major Depressive Disorder
Renal information and dialysis
The label does not routinely require a lower dose or longer interval for renal impairment. In 12 dialysis patients, 20 mg/day produced parent/metabolite concentrations comparable to normal renal function; possible accumulation of other renally eliminated metabolites is acknowledged.
Review suicidality, serotonin syndrome and interacting medicines. Delayed steady state and the prolonged elimination of fluoxetine/norfluoxetine matter when adjusting or switching treatment.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.