GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Fluoxetine daily capsules (adults)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug2 sources available - open source summaries, references and comparisons

Prozac

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Official source

Fluoxetine daily capsules (adults) - selected U.S. labeling

Product / population
Adult major depressive disorder; daily oral immediate-release fluoxetine capsules. Excludes weekly delayed-release products and olanzapine combinations.
Renal measure
Qualitative renal guidance, supported by a small dialysis pharmacokinetic study; no CrCl dose table.
Labeled basic dosing

Start 20 mg orally each morning. Consider escalation after several weeks when response is insufficient. Doses above 20 mg/day may be once daily or divided morning/noon; maximum 80 mg/day.

Renal information and dialysis

The label does not routinely require a lower dose or longer interval for renal impairment. In 12 dialysis patients, 20 mg/day produced parent/metabolite concentrations comparable to normal renal function; possible accumulation of other renally eliminated metabolites is acknowledged.

Selected warnings and limits

Review suicidality, serotonin syndrome and interacting medicines. Delayed steady state and the prolonged elimination of fluoxetine/norfluoxetine matter when adjusting or switching treatment.

Source revision: Label revision date not separately recorded; retrieval date is not the revision date. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8609ed02-0b30-4c82-bab1-4d51d92ec224

Scope: Selected dosing/renal sections read; concise local summary, not full prescribing information. GlobalRPh v6.6.

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Official product label

Fluoxetine daily capsules (adults) - selected U.S. labeling

Adult major depressive disorder; daily oral immediate-release fluoxetine capsules. Excludes weekly delayed-release products and olanzapine combinations.

Renal method: Qualitative renal guidance, supported by a small dialysis pharmacokinetic study; no CrCl dose table.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
Handbook

Renal Drug Handbook, fifth edition - Fluoxetine daily capsules (adults)

Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Official source

Fluoxetine daily capsules (adults) - selected U.S. labeling

Adult major depressive disorder; daily oral immediate-release fluoxetine capsules. Excludes weekly delayed-release products and olanzapine combinations.

Method: Qualitative renal guidance, supported by a small dialysis pharmacokinetic study; no CrCl dose table.

Renal information and dialysisRead this complete source summary
Handbook source

Renal Drug Handbook, fifth edition - Fluoxetine daily capsules (adults)

Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.

Historical renal and dialysis observationsRead this complete source summary

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Original content / product scopeFluoxetine daily capsules (adults) - selected U.S. labelingRenal Drug Handbook, fifth edition - Fluoxetine daily capsules (adults)
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8609ed02-0b30-4c82-bab1-4d51d92ec224

Product and population scope

Adult major depressive disorder; daily oral immediate-release fluoxetine capsules. Excludes weekly delayed-release products and olanzapine combinations.

RDM31-fluoxetine-ir-scope · Source section: Editorial scope tied to selected U.S. labelRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Fluoxetine daily capsules (adults) - selected U.S. labeling

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U.S. product labeling / DailyMed · Adult major depressive disorder; daily oral immediate-release fluoxetine capsules. Excludes weekly delayed-release products and olanzapine combinations.

Renal method: Qualitative renal guidance, supported by a small dialysis pharmacokinetic study; no CrCl dose table.
Source date: Label revision date not separately recorded; retrieval date is not the revision date.
Retrieved: 2026-09-05

Selected dosing/renal sections read; concise local summary, not full prescribing information.

Labeled basic dosing

Start 20 mg orally each morning. Consider escalation after several weeks when response is insufficient. Doses above 20 mg/day may be once daily or divided morning/noon; maximum 80 mg/day.

RDM31-fluoxetine-ir-label-dose · Source locator: 2.1 Major Depressive Disorder

Renal information and dialysis

The label does not routinely require a lower dose or longer interval for renal impairment. In 12 dialysis patients, 20 mg/day produced parent/metabolite concentrations comparable to normal renal function; possible accumulation of other renally eliminated metabolites is acknowledged.

RDM31-fluoxetine-ir-label-renal · Source locator: 12.3 Renal Disease

Selected warnings and limits

Review suicidality, serotonin syndrome and interacting medicines. Delayed steady state and the prolonged elimination of fluoxetine/norfluoxetine matter when adjusting or switching treatment.

RDM31-fluoxetine-ir-label-limits · Source locator: Boxed warning; 5; 12.3 Accumulation and slow elimination

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8609ed02-0b30-4c82-bab1-4d51d92ec224
Retrieved
2026-09-05
DailyMed Set ID
8609ed02-0b30-4c82-bab1-4d51d92ec224
Renal-function method
Qualitative renal guidance, supported by a small dialysis pharmacokinetic study; no CrCl dose table.
Source date/version
Label revision date not separately recorded; retrieval date is not the revision date.
Hash meaning
SHA-256 identifies this local summary, not original SPL XML or label PDF.
Local summary SHA-256
bca97575c4f0863431aa70237754e8dbc89699e8fdd9db484990d2d6a2852f5b
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, fifth edition - Fluoxetine daily capsules (adults)

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UK Renal Pharmacy Group / CRC Press · Historical renal/RRT cross-check for the named ingredient; not a current U.S. prescribing instruction.

Renal method: Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source date: Fifth edition, 2019
Retrieved: 2026-09-05

Historical source, separately displayed. Renal tables were read with page-image inspection.

Historical renal and dialysis observations

The book retains ordinary dosing at 20-50 and 10-20 mL/min, but below 10 suggests low doses or alternate-day dosing with response-guided escalation. It describes little dialysis removal and applies the below-10 approach to intermittent and peritoneal modalities; continuous therapy uses its 10-20 band.

RDM31-fluoxetine-ir-book · Source locator: Dose in renal impairment; renal replacement therapies; Other information

Source-specific limits

The historical below-10 advice is more conservative than the selected label. These are alternative source positions, not a combined schedule.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
Printed page(s) 441-442; PDF page(s) 460,461
Renal-function method
Book table headings say GFR (mL/min); the preface states adjustment information is based on Cockcroft-Gault CrCl, not indexed eGFR. Do not substitute methods.
Source date/version
Fifth edition, 2019
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8609ed02-0b30-4c82-bab1-4d51d92ec224
Hash meaning
SHA-256 identifies the local paraphrase; the source PDF is not redistributed.
Local summary SHA-256
5b34a590007480e16e6ed5c3bea9a723a10be36f1ee67bc7edc1534f43d448c0

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8609ed02-0b30-4c82-bab1-4d51d92ec224
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
7e6181ebb87a6ac9aee84969eb148f8e183505eeb639a883531a6c6f258bfe1e
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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