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Clinical context remains essential
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UCSF cephalexin - selected bloodstream-infection and dialysis rows
Product / population
Adult institutional oral therapy for selected gram-negative bloodstream infection; eligibility not established by the renal table alone.
Renal method
Renal table mL/min; institutional CrCl context; intermittent versus continuous HD kept separate.
Source revision
Source revision date not established in selected retrieval.
Retrieved
2026-09-07
Local review status
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Documented differences and cautions on this drug
All record notes are retained here, including notes about sources not selected in this review.
Label maximum differs from institution-specific bacteremia dosing
The KEFLEX renal table caps the daily dose in moderate impairment. UCSF uses a different high-dose strategy for selected gram-negative bloodstream infection; Stanford also has a distinct HD regimen.
What to reconcile: The indication and regimen must stay together. Do not average the doses or relabel the bloodstream-infection schedule as a general renal dose.
Source difference identified; final patient-specific adjudication required.
Label daily cap versus indication-specific institutional bloodstream doses
KEFLEX limits total daily dose to 1 g at CrCl 30-59 and has insufficient HD adjustment information. UCSF uses higher selected Gram-negative bloodstream-infection doses and supplies an intermittent-HD row.
What to reconcile: Assess infection eligibility, organism susceptibility, patient setting and institutional policy. Keep the complete institutional regimen separate from the label; do not transfer the bloodstream schedule to routine cystitis or children.
UCSF Infectious Diseases Management Program · Adult institutional oral therapy for selected gram-negative bloodstream infection; eligibility not established by the renal table alone.
Renal method: Renal table mL/min; institutional CrCl context; intermittent versus continuous HD kept separate. Source date: Source revision date not established in selected retrieval. Retrieved: 2026-09-07
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.
Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.
Renal dosing, restrictions and evidence limits
For the gram-negative bloodstream-infection row: >50 mL/min, 1000 mg four times daily; 30-50, 1000 mg three times daily; 15-29, 1000 mg twice daily; <15, 500 mg three times daily. Intermittent HD: 500 mg twice daily for that indication. Continuous-HD data are absent. These selected institutional doses differ from the KEFLEX label renal cap and are not general-purpose cystitis or pediatric schedules. Two other nondialysis rows rendered with merged cells and were not re-transcribed in this supplement.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.