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1 local source card selected. Local card fingerprints checked where supplied. This is not an original-document hash, source-currency guarantee or clinical approval. Record-level cautions below are the current library's cautions, not a frozen prior version.
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Clinical context remains essential
Independent clinical review is pending. Confirm indication, exact formulation/route, population, renal measure and units, kidney-function stability, dialysis prescription, interacting drugs, monitoring and source revision. An RX mirror and its original label are not independent corroboration. Missing disagreement notes do not certify agreement.
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Pemetrexed disodium for injection (Alimta) - selected U.S. label sections
Product / population
ALIMTA lyophilized IV product for the applicable adult oncology indication. Not a ready-to-use preparation instruction.
Renal method
Cockcroft-Gault creatinine clearance in mL/min
Source revision
Revision not captured; retrieval date is not the revision date.
Retrieved
2026-09-05
Local review status
Local label summary; independent clinical review pending. Not a two-source validated protocol.
Official
Pemetrexed disodium for injection (Alimta) - selected U.S. label sections
U.S. product labeling / DailyMed · ALIMTA lyophilized IV product for the applicable adult oncology indication. Not a ready-to-use preparation instruction.
Renal method: Cockcroft-Gault creatinine clearance in mL/min Source date: Revision not captured; retrieval date is not the revision date. Retrieved: 2026-09-05
Local label summary; independent clinical review pending. Not a two-source validated protocol.
Renal eligibility and monitoring
The labeled regimens apply to Cockcroft-Gault CrCl at least 45 mL/min. Below 45, no dose is recommended. Assess CrCl before each cycle and do not administer below 45. Do not invent a lower-dose substitute.
For CrCl 45-79 mL/min, avoid ibuprofen during the 2 days before pemetrexed, the administration day, and the following 2 days. If concomitant use cannot be avoided, monitor more closely for marrow suppression, renal toxicity and gastrointestinal toxicity.
Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.
Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.
This reference does not select a regimen. Complete the indication, measured/estimated renal function and trend, dialysis setting, source rationale, monitoring and reassessment plan in your institution's approved documentation system. Confirm the complete current source before adopting its regimen.
GlobalRPh v6.6 | RDM66-DIRECT-PHP-20260911 | Local library date 2026-09-11. Selected-card identity does not imply clinical verification.