GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Pemetrexed disodium for injection (Alimta)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons

Alimta

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Official source

Pemetrexed disodium for injection (Alimta) - selected U.S. label sections

Product / population
ALIMTA lyophilized IV product for the applicable adult oncology indication. Not a ready-to-use preparation instruction.
Renal measure
Cockcroft-Gault creatinine clearance in mL/min

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Renal eligibility and monitoring

The labeled regimens apply to Cockcroft-Gault CrCl at least 45 mL/min. Below 45, no dose is recommended. Assess CrCl before each cycle and do not administer below 45. Do not invent a lower-dose substitute.

Ibuprofen interaction in renal impairment

For CrCl 45-79 mL/min, avoid ibuprofen during the 2 days before pemetrexed, the administration day, and the following 2 days. If concomitant use cannot be avoided, monitor more closely for marrow suppression, renal toxicity and gastrointestinal toxicity.

Source revision: Revision not captured; retrieval date is not the revision date. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5a860f3-37ec-429c-ae04-9c88d7c55c08

Scope: Local label summary; independent clinical review pending. Not a two-source validated protocol. GlobalRPh v6.6.

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Official product label

Pemetrexed disodium for injection (Alimta) - selected U.S. label sections

ALIMTA lyophilized IV product for the applicable adult oncology indication. Not a ready-to-use preparation instruction.

Renal method: Cockcroft-Gault creatinine clearance in mL/min
Retrieved: 2026-09-05

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Original content / product scopePemetrexed disodium for injection (Alimta) - selected U.S. label sections
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5a860f3-37ec-429c-ae04-9c88d7c55c08

Product and population scope

ALIMTA lyophilized IV product for the applicable adult oncology indication. Not a ready-to-use preparation instruction.

RDM32-pemetrexed-alimta-scope · Source section: Editorial scope for the selected U.S. labelRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

Pemetrexed disodium for injection (Alimta) - selected U.S. label sections

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U.S. product labeling / DailyMed · ALIMTA lyophilized IV product for the applicable adult oncology indication. Not a ready-to-use preparation instruction.

Renal method: Cockcroft-Gault creatinine clearance in mL/min
Source date: Revision not captured; retrieval date is not the revision date.
Retrieved: 2026-09-05

Local label summary; independent clinical review pending. Not a two-source validated protocol.

Renal eligibility and monitoring

The labeled regimens apply to Cockcroft-Gault CrCl at least 45 mL/min. Below 45, no dose is recommended. Assess CrCl before each cycle and do not administer below 45. Do not invent a lower-dose substitute.

RDM32-pemetrexed-alimta-1 · Source locator: 2.3; 2.6; 8.6

Ibuprofen interaction in renal impairment

For CrCl 45-79 mL/min, avoid ibuprofen during the 2 days before pemetrexed, the administration day, and the following 2 days. If concomitant use cannot be avoided, monitor more closely for marrow suppression, renal toxicity and gastrointestinal toxicity.

RDM32-pemetrexed-alimta-2 · Source locator: 2.5; 7.1

Source-specific limits

Selected renal sections only, not a complete monograph. Exact product, indication, patient population, renal method and all other contraindications/interactions remain controlling.

Second independent renal reference and clinician adjudication remain pending; no all-indication, dialysis or pediatric dose may be inferred from an omitted field.

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5a860f3-37ec-429c-ae04-9c88d7c55c08
Retrieved
2026-09-05
DailyMed Set ID
f5a860f3-37ec-429c-ae04-9c88d7c55c08
Renal-function method
Cockcroft-Gault creatinine clearance in mL/min
Source date/version
Revision not captured; retrieval date is not the revision date.
Hash meaning
SHA-256 identifies this local summary, not original SPL XML or a label PDF.
Local summary SHA-256
7a9d8c699ba8093ffba4c908ed4c9c1db274a14d9805c10609f6669cf5c59d0b

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5a860f3-37ec-429c-ae04-9c88d7c55c08
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
22a0132eab2efda947661d0ddc2fd70f5e58fe02ca1512272bf35bcc1c8ac015
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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