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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Thiopental - Pentothal ®

Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Thiopental - Pentothal ® (opens in a new tab)Original source URL: https://globalrph.com/dilution/thiopental/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/thiopental/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:49:58.122469+00:00
Source location
div.post-content
Packaged content SHA-256
e35e0474c3d03fd84ebd0dfc5fa45a4a615c16e75b448ce2e332a4149ec53e7b
Original response SHA-256
a1ff4e446ebb0abcb069a25d4e7e9b160ae12a119848a1a674a98de38aa2d9a0
Source body SHA-256
e79cb06319095653ed4ee505930148abc747de3c4092ed1167fffd67b8d5509b

Thiopental Sodium (Pentothal ®)
The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents
D5W, NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
Intermittent IV administration:
(2 to 5% solution is recommended) .
[1-2 grams] [50 ml] [As directed]
[5 grams][100-250ml][As directed]
[10 grams] [500 ml] [As directed]

Continuous infusion:
(0.2 to 0.4% solution is recommended ) .
[1 gram] [250 ml] or
[2 grams] [500ml]

Stability / Miscellaneous
EXP: 3 days (RT); 7 days(REF).

Onset: 30-60 seconds.
Duration: 10-30 minutes.
Ultra short acting barbiturate.

Given by slow intravenous administration only.

Dosing:
Anesthesia induction (adults): 3-5 mg/kg (2.5% solution) Maintenance: 25-100mg IV as needed.

Increased intracranial pressure: 1.5 to 5 mg/kg/dose; repeat as needed to control intra-cranial pressure.

Seizures: 75 to 250mg/dose. Repeat as needed. [case study: 250 mg IV bolus followed by 80-120 mg/hr.]

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