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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Thiopental

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Thiopental - Pentothal ® (opens in a new tab)Original source URL: https://globalrph.com/dilution/thiopental/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/thiopental/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:49:58.122469+00:00
Source location
div.post-content
Packaged content SHA-256
e35e0474c3d03fd84ebd0dfc5fa45a4a615c16e75b448ce2e332a4149ec53e7b
Original response SHA-256
a1ff4e446ebb0abcb069a25d4e7e9b160ae12a119848a1a674a98de38aa2d9a0
Source body SHA-256
e79cb06319095653ed4ee505930148abc747de3c4092ed1167fffd67b8d5509b

Thiopental Sodium (Pentothal ®)

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

D5W, NS

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

Intermittent IV administration:
(2 to 5% solution is recommended) .
[1-2 grams] [50 ml] [As directed]
[5 grams][100-250ml][As directed]
[10 grams] [500 ml] [As directed]

Continuous infusion:
(0.2 to 0.4% solution is recommended ) .
[1 gram] [250 ml] or
[2 grams] [500ml]

Stability / Miscellaneous

EXP: 3 days (RT); 7 days(REF).

Onset: 30-60 seconds.
Duration: 10-30 minutes.
Ultra short acting barbiturate.

Given by slow intravenous administration only.

Dosing:
Anesthesia induction (adults): 3-5 mg/kg (2.5% solution) Maintenance: 25-100mg IV as needed.

Increased intracranial pressure: 1.5 to 5 mg/kg/dose; repeat as needed to control intra-cranial pressure.

Seizures: 75 to 250mg/dose. Repeat as needed. [case study: 250 mg IV bolus followed by 80-120 mg/hr.]

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
current_label_review_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      thiopental
      Source IDH51-510D68A37D8AF5127F2D838E
      Generic name
      Thiopental
      Source IDH51-1C160C0CB282D2C1F644A482
      Class
      Sedation, analgesia, and anesthesia
      Source IDH51-4B35D4B6537FC91877D3B97E
      Subclass
      Legacy GlobalRPh directory entry
      Source IDH51-1F7232393C825CAEC2A05B71
      Primary uses
      1. Analgesia, sedation, induction, or peri-procedural therapy depending on the named agent and monitoring environment.
        Source IDH51-ADB2C2E3DEDD082B51349577
      Mechanism
      Enhances GABA-A receptor inhibition, mainly by prolonging chloride-channel opening.
      Source IDH51-BABEED3ADC4F4453E303F00D
      Mechanism level
      drug_specific
      Source IDH51-1C7DCB2FB31EFBC7241DD6DD
      Basic dosing orientation
      The existing GlobalRPh dose and preparation quick reference loads automatically below. Treat it as historical continuity, then confirm the exact current DailyMed label, population, indication, renal function, and institutional policy.
      Source IDH51-67F8A28ADAEDED1BE455C9F6
      Administration orientation
      Route, dilution, concentration, and administration details load automatically from the existing GlobalRPh quick reference below; current exact-product verification remains required.
      Source IDH51-B7DE62AB29CE513EC39C5D62
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-94F2C7BA8FEFBF7EE929233A
      Key safety orientation
      1. Legacy content must be reconciled against current labeling and institutional policy before clinical use.
        Source IDH51-D77255706E938E5F7187A87E
      Coverage path
      automatic_legacy_quick_reference
      Source IDH51-BA509F1A47C4939D79E59475
      Coverage path label
      Automatic legacy GlobalRPh quick reference
      Source IDH51-37102D5C425CC8C3BDF393CD
      Legacy title
      Thiopental
      Source IDH51-9791986F3B39523D0DF8D423
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-968964F55F61B413FF8FA81B
      Search text
      Thiopental Sedation, analgesia, and anesthesia Legacy GlobalRPh directory entry Analgesia, sedation, induction, or peri-procedural therapy depending on the named agent and monitoring environment. Enhances GABA-A receptor inhibition, mainly by prolonging chloride-channel opening. The existing GlobalRPh dose and preparation quick reference loads automatically below. Treat it as historical continuity, then confirm the exact current DailyMed label, population, indication, renal function, and institutional policy. Route, dilution, concentration, and administration details load automatically from the existing GlobalRPh quick reference below; current exact-product verification remains required. Renal dosing status has not been locally normalized; use the current package insert before ordering or administration. Legacy content must be reconciled against current labeling and institutional policy before clinical use. Automatic legacy GlobalRPh quick reference
      Source IDH51-CB6F40A56BAE60420352CD49
      Official access mode
      none
      Source IDH51-7871C1A8A0805407493B4739
      Official access reason
      No source-backed DailyMed action has been verified for this umbrella or legacy record; identify the exact product before searching.
      Source IDH51-C5C9F01A8F27392B6903D398

      No separate structured rows were bundled for preparation, IV push, continuous infusion, population dosing, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      current_label_review_required
      Source IDH51-7AB566F5F318A3F98531D641
      Summary
      Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-43C9F9F552031AB5B5600729
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-BF5E3230734B575976912B0B

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Legacy content must be reconciled against current labeling and institutional policy before clinical use.
        Source IDH51-BE07FE07D9246BF9E08860D1

      Historical Stability notes

      Recovered v5.1 source content; historical, awaiting current review.

      1. Legacy product stability information is not automatically equivalent to a USP <797> BUD.
        Source IDH51-AEC65D2A06FCFF5D2805F3BF
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      thiopental
      Source IDH51-52A44B1DBF41526D7BA7D7DB
      Legacy title
      Thiopental
      Source IDH51-7A1BF640C707BEBA623B1E8B
      Generic name
      Thiopental
      Source IDH51-09847C2C25C1595F5A2F0E78
      Class
      Sedation, analgesia, and anesthesia
      Source IDH51-20455DA7ED24DB5D06887523
      Subclass
      Legacy GlobalRPh directory entry
      Source IDH51-57A3A02E9AC9E75DDBF8DF6E
      Summary
      Existing GlobalRPh IV dilution monograph retained for migration into the unified reference.
      Source IDH51-BD20D264C2E3EF130B6E5BA9
      Populations
      1. Population not yet normalized
        Source IDH51-3607358E1670EE20FB4615F1
      Evidence tier
      Legacy catalog - migration review required
      Source IDH51-AC72684E60DF6C671FA2ABD2
      High alert
      false
      Source IDH51-6EE48157AC0FBCC3CAFEAD60
      Hazardous
      false
      Source IDH51-C5E0A4BF20EF1AF9775D6A21
      Status
      Legacy migration
      Source IDH51-F14FA78DC654EDFF4AAD558E
      Version added
      Legacy
      Source IDH51-46F7FB84CCDD9267171FBC7B
      Sources
      LabelUrlKind
      Source IDH51-C41BEEABA1C6FA47210D0146
      GlobalRPh legacy IV dilution monograph
      Source IDH51-37F81A96898BD6D13378A0D0
      legacy:auto
      Source IDH51-80D9467B6683C6AE445A56D0
      Legacy
      Source IDH51-176939D06D6E2744A4A869E4
      Clinical release verification
      Audit version
      3.4
      Source IDH51-13AC762219361F144D82E5CA
      Audited on
      2026-08-30
      Source IDH51-17879DDF7EBEA00FDAD2B3D6
      Level
      red
      Source IDH51-BB22954778F8613B10355CEA
      Release gate
      unverified_or_unclassified_sources_do_not_release_as_current
      Source IDH51-B5F97BC5FA303941BBFD3716
      Exact current label candidate
      false
      Source IDH51-A92C763BF4DCADB0427B0D72
      Reference url count
      0
      Source IDH51-764491E145C1031B840E5604
      Broken reference count
      0
      Source IDH51-4BFFD66280BF56E90DB5842A
      Point of use confirmation required
      true
      Source IDH51-FCC85D4DEDFB4EE3E5E9A72E
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-0069D7E2119536312F2E8385

      Dosing source fields

      Id
      thiopental
      Source IDH51-F460114DBFF53780C0411A00
      Generic name
      Thiopental
      Source IDH51-475EFAF5B376E6EC5C889700
      Coverage status
      direct_official_label_access_plus_legacy_reference
      Source IDH51-E300370765ABA2CDBE3AD0E8
      Package insert
      Query name
      Thiopental
      Source IDH51-7B164B9A370A88DA9AD45A78
      Product and route must match
      true
      Source IDH51-C07B9235F843FAC4F8DBD8DB
      Live current label enabled
      false
      Source IDH51-246ED9240B762570CA0E99EE
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-4BF1B7466A97519265A8F786
      Direct official label access enabled
      true
      Source IDH51-244E47B0E558047CC61F8A63
      Outbound server request required
      false
      Source IDH51-0428773FBC5BAF505D0C8A36
      Local summary status
      not_bundled
      Source IDH51-829B532A4B2C3CB350EA5B03
      Clinical review
      Locally normalized
      false
      Source IDH51-A27FE98CF5BACD2D72AB86CF
      Reviewed
      2026-08-29
      Source IDH51-48B551189648F4ADBF0D33A4
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-A93E6B0E881823EF6A566609
      Clinical release verification
      Audit version
      3.4
      Source IDH51-F94FAED51C93129370EB701B
      Audited on
      2026-08-30
      Source IDH51-210F9C4651C4E3F5301F4806
      Level
      red
      Source IDH51-7D8030177CCDDE337FC2427B
      Release gate
      unverified_or_unclassified_sources_do_not_release_as_current
      Source IDH51-4D0CBE636F1C11664335815C
      Exact current label candidate
      false
      Source IDH51-8FFDF72063DE472D95629A6A
      Reference url count
      0
      Source IDH51-4C42ABD6B015F5362EF11AC6
      Broken reference count
      0
      Source IDH51-4D3AF7D8342806CA96E7A66A
      Point of use confirmation required
      true
      Source IDH51-3BFEFFEFE728CA9423BF1396
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-5A207A7D92E6F6D451F080B1
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      thiopental
      Source IDH51-836C716D666D0C82CEA4D8AC
      Name
      Thiopental
      Source IDH51-0C2625E986DD37D1CD1D5332
      Therapeutic class
      Sedation, analgesia, and anesthesia
      Source IDH51-E3BBC2CFC25F960C4922F205
      Review version
      3.1
      Source IDH51-93C48037BF0F234C7AFCE799
      Review date
      2026-08-30
      Source IDH51-720FBA315AB0B8332F140D34
      Release status
      no_released_dilution_current_label_review_required
      Source IDH51-34176CF8637C6F7C85706FCF
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-C2D016DBD47BA6F9ED8E7B23
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-42B48CEA5863CC1F28445277
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-91D52FC963483388C3364734
      Reconstitution concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-01121705EE9D4EE723C25FB5
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-755EB49C23AC1A45151C3C3C
      Appropriate standardized containers
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-4A28F86546B20B9BB974D883
      Adult dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-B3411ACFFA8F8E39303C8777
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-73CC48CBF279934094F0F7ED
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-8B201AE336CE7ADFBF99CFE0
      Infusion time
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-C7427B7BB3BFB374D6186D44
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-7635F3EFDB97547579457266
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-DADD11A842A0E1AC8548FF9E
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-B97B7362CD4182097C1AEF4C
      Reconstitution concentration
      Primary
      not_found
      Source IDH51-C439E16AE68020189A52AAA0
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-F397C2CF75219C2004BE9F61
      Appropriate standardized containers
      Primary
      not_found
      Source IDH51-BC9CA242248CE076A1AC7A19
      Adult dosing range
      Primary
      not_found
      Source IDH51-FE991D93900CDE4419A52363
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-D51C62B9076792FC1928D339
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-FDD3ED2F46D13ED21FEFE066
      Infusion time
      Primary
      not_found
      Source IDH51-1950B4808D7D6C6B803D8D56
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-B08A35493628E2EBF7708DED
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-F3BE110EE1D1B9EFD3337AAA
      Population applicability
      Adult
      Applicability
      not_established
      Source IDH51-DBDF3BB508CFE3752C6FAA6D
      Guide generation allowed
      false
      Source IDH51-D81C3C92970AD884BDF67E1C
      Pediatric
      Applicability
      not_established
      Source IDH51-986BD5B56A9BCB1702F0FF13
      Guide generation allowed
      false
      Source IDH51-9794386984241C9883453DDE
      Neonatal
      Applicability
      not_established
      Source IDH51-5C5C5EA56BF72BD575165A69
      Guide generation allowed
      false
      Source IDH51-5AAECEC32B88DB7CB693A36C
      Route presence
      Structured dilution
      false
      Source IDH51-7DD918A930B0BC90EE6CC03D
      Iv push
      false
      Source IDH51-1D75052978E6B0E6E9EAE6F6
      Continuous infusion
      false
      Source IDH51-26740D5300DC4FFDF8D9B381
      Pediatric source
      false
      Source IDH51-85DAC264678B50E9620C373E
      Neonatal source
      false
      Source IDH51-153B1B218E3AC87EA570A45E
      Legacy reference
      Status
      not_available
      Source IDH51-B1F853F1652CBAFC2054D8F7
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-0CD6C40FA43C540B4DF9A15A
      Source files
      1. catalog.json
        Source IDH51-DFBC4176BC1E68B431AB7EA7
      2. dosing.json
        Source IDH51-AF8C999BBCD3A90FB088C1C7
      3. legacy-map.json
        Source IDH51-DC295CE8504199A2F871CC30
      4. review-queue.json
        Source IDH51-931730700513BB491E50B0A7
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-ACE3FC9C53379DCDFD68BE36
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-52A44B1DBF41526D7BA7D7DBcatalog.json
      /records/237/id
      Historical; current review incomplete
      H51-7A1BF640C707BEBA623B1E8Bcatalog.json
      /records/237/legacy_title
      Historical; current review incomplete
      H51-09847C2C25C1595F5A2F0E78catalog.json
      /records/237/generic_name
      Historical; current review incomplete
      H51-20455DA7ED24DB5D06887523catalog.json
      /records/237/class
      Historical; current review incomplete
      H51-57A3A02E9AC9E75DDBF8DF6Ecatalog.json
      /records/237/subclass
      Historical; current review incomplete
      H51-BD20D264C2E3EF130B6E5BA9catalog.json
      /records/237/summary
      Historical; current review incomplete
      H51-BE07FE07D9246BF9E08860D1catalog.json
      /records/237/warnings/0
      Historical; current review incomplete
      H51-AEC65D2A06FCFF5D2805F3BFcatalog.json
      /records/237/stability_notes/0
      Historical; current review incomplete
      H51-3607358E1670EE20FB4615F1catalog.json
      /records/237/populations/0
      Historical; current review incomplete
      H51-AC72684E60DF6C671FA2ABD2catalog.json
      /records/237/evidence_tier
      Historical; current review incomplete
      H51-6EE48157AC0FBCC3CAFEAD60catalog.json
      /records/237/high_alert
      Historical; current review incomplete
      H51-C5E0A4BF20EF1AF9775D6A21catalog.json
      /records/237/hazardous
      Historical; current review incomplete
      H51-F14FA78DC654EDFF4AAD558Ecatalog.json
      /records/237/status
      Historical; current review incomplete
      H51-992E22315060CF9F9263C955catalog.json
      /records/237/reviewed
      Historical; current review incomplete
      H51-46F7FB84CCDD9267171FBC7Bcatalog.json
      /records/237/version_added
      Historical; current review incomplete
      H51-C41BEEABA1C6FA47210D0146catalog.json
      /records/237/sources/0
      Historical; current review incomplete
      H51-37F81A96898BD6D13378A0D0catalog.json
      /records/237/sources/0/label
      Historical; current review incomplete
      H51-80D9467B6683C6AE445A56D0catalog.json
      /records/237/sources/0/url
      Historical; current review incomplete
      H51-176939D06D6E2744A4A869E4catalog.json
      /records/237/sources/0/kind
      Historical; current review incomplete
      H51-13AC762219361F144D82E5CAcatalog.json
      /records/237/clinical_release_verification/audit_version
      Historical; current review incomplete
      H51-17879DDF7EBEA00FDAD2B3D6catalog.json
      /records/237/clinical_release_verification/audited_on
      Historical; current review incomplete
      H51-BB22954778F8613B10355CEAcatalog.json
      /records/237/clinical_release_verification/level
      Historical; current review incomplete
      H51-B5F97BC5FA303941BBFD3716catalog.json
      /records/237/clinical_release_verification/release_gate
      Historical; current review incomplete
      H51-A92C763BF4DCADB0427B0D72catalog.json
      /records/237/clinical_release_verification/exact_current_label_candidate
      Historical; current review incomplete
      H51-0962324CC4A6A6B5F8908B7Bcatalog.json
      /records/237/clinical_release_verification/selected_setid
      Historical; current review incomplete
      H51-75D3FFAFA42875775DC05115catalog.json
      /records/237/clinical_release_verification/selected_label_title
      Historical; current review incomplete
      H51-8D6717272569EA665EA89F1Ecatalog.json
      /records/237/clinical_release_verification/numeric_support_ratio
      Historical; current review incomplete
      H51-764491E145C1031B840E5604catalog.json
      /records/237/clinical_release_verification/reference_url_count
      Historical; current review incomplete
      H51-4BFFD66280BF56E90DB5842Acatalog.json
      /records/237/clinical_release_verification/broken_reference_count
      Historical; current review incomplete
      H51-FCC85D4DEDFB4EE3E5E9A72Ecatalog.json
      /records/237/clinical_release_verification/point_of_use_confirmation_required
      Historical; current review incomplete
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