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Preparation. Administration. Evidence.

IV Dilution &
Medication Reference

Search 255 medications, read preserved historical references, and inspect separately reviewed preparation statements. Full monograph updates remain pending.

Version 6.4Release date 2026-11-04For healthcare professionals
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Medication reference

Streptokinase

Monograph awaiting updateThis monograph will be updated in the future.

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Historical source. Current clinical review is incomplete. This monograph will be updated in the future.

Streptokinase (opens in a new tab)Original source URL: https://globalrph.com/dilution/streptokinase/ | Retrieved 2026-11-04

Source dates, location and integrity

This historical article is separate from the reviewed claim cards. Product formulations and source dates may differ.

Original source URL
https://globalrph.com/dilution/streptokinase/ (opens in a new tab)
Source date
Not established in the retrieved source
Retrieved
2026-11-04T19:50:48.437362+00:00
Source location
div.post-content
Packaged content SHA-256
a2bcf3c784a8d1127500d68f02ee598a0a26019e6fc56432399eb1e3505464ad
Original response SHA-256
bc2ab7fda3226f37090a14932858dbe29a9269ca06ac0c0ee2325522f8fdd83e
Source body SHA-256
f848b94681096f091d4cd03e0b01c235ad67f0929e8168d383239fcdb9800815

Streptokinase

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

NS, D5W

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

[250,000 u] [50 ml] [30 min]
[1,500,000 u] [50-250ml] [60 min]

Stability / Miscellaneous

Prepare just before use.
Avoid shaking to prevent foaming.

Acute MI: Give 1.5 million IU over 60 minutes.
PE: Loading dose: 250,000 iu over 30 minutes, followed by 100,000 iu/ hr x 24 hours. (x 72 hours for DVT).

Reconstitute the 250, 600, 750k with 5 ml NS. 1.5 mu with 10ml. Do not add more than 1.5 mu to an IV solution (limited stability).

Review contraindications - See Package Insert

Obtain baseline CBC, hct, platelet, PT/PTT, CPK, CPKmb, fibrinogen.
Source: [package insert]

Open this historical article on its own

Product identifiers and clinical review status

This monograph will be updated in the future. Historical material is available where present in the original sources; full current exact-product and claim-level review remains pending.

Exact formulation, concentration, container, manufacturer, regulatory identifiers, and a reproducible label snapshot have not all been reconciled.

What remains to be completed
  • Retrievable exact-product SPL XML with version, revision, retrieval date and reproducible hash
  • Clinically reviewed, individually identified statements with two exact source mappings
  • Exact formulation, strength, container, manufacturer/labeler, application and NDC reconciliation
  • Renal-function methods and dialysis/CRRT modality review where applicable
  • Mechanism provenance, clinical source disagreements and full medication-specific safety reconciliation

Supplemental historical fields

Restored-data provenance and review notes

Source release: 2026-08-31. Current clinical review is incomplete. Original uses of current, verified, or normalized describe the historical source. They do not inherit the status of separately reviewed statements. Product formulations and source dates can differ.

Current review annotations for historical renal, dialysis, mechanism, and product fieldsSeparate renal reference: Open Renal Dosing Master (opens in a new tab)
Renal
Status
not_locally_normalized
Original classification
current_label_review_required
Entries
    General note
    Preserve the source-specific renal-function basis. An indexed CrCl table is not interchangeable with unindexed CrCl or eGFR. Generic advice to check a method does not identify the equation for a dose row.
    Dialysis
    Status
    no_local_structured_regimen
    Entries
      General note
      Named modality alone does not establish applicability. CRRT subtype, effluent rate, residual renal function, timing and interruptions require review. Historical absence is not evidence that no guidance exists.
      Mechanisms
      • Source kind
        first_look
        Local pointer
        /mechanism
        Original level
        drug_specific
        Provenance classification
        historical_drug_specific_uncorroborated
        Label derived verified
        false
        Independently corroborated
        false
        Exact label section
        Not recorded
        Original source note
        Not recorded
        Review status
        historical_unverified
        Note
        Drug-specific wording in the old file is not proof of independent corroboration or an exact label locator. Consult separately published current mechanism claims where present.
      Future update
      Status
      pending_review
      Message
      This monograph will be updated in the future as current exact-product and claim-level review is completed.
      Source unavailable
      false
      Reason
      The historical content is restored; comprehensive contemporary verification remains incomplete.
      Historical first look: uses, mechanism, dosing context, and administration

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      streptokinase
      Source IDH51-AF4C48A0578E07E1CD3A5127
      Generic name
      Streptokinase
      Source IDH51-7FBCB1C92B48CE205649F3E7
      Class
      Anticoagulation and hemostasis
      Source IDH51-DFC6A7B4BA64EB9535BB9289
      Subclass
      Legacy GlobalRPh directory entry
      Source IDH51-2B0B4D0A44B9833FA80A595E
      Primary uses
      1. Anticoagulation, platelet inhibition, thrombolysis, bleeding reversal, or coagulation-factor replacement, depending on the named agent.
        Source IDH51-8A9B85EFBF99201F27A45A18
      Mechanism
      Forms a plasminogen activator complex that generates plasmin and produces systemic fibrinolysis.
      Source IDH51-E9DD42A270C6E18318F48C71
      Mechanism level
      drug_specific
      Source IDH51-6EC768548D3F20891AD90F4E
      Basic dosing orientation
      The existing GlobalRPh dose and preparation quick reference loads automatically below. Treat it as historical continuity, then confirm the exact current DailyMed label, population, indication, renal function, and institutional policy.
      Source IDH51-578F3BE798907F27E7C26972
      Administration orientation
      Route, dilution, concentration, and administration details load automatically from the existing GlobalRPh quick reference below; current exact-product verification remains required.
      Source IDH51-612BFDE4BBBB1306BFA34044
      Renal and population orientation
      Separate renal reference: Open Renal Dosing Master (opens in a new tab)Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-56BF62BB31859EF286A35C99
      Key safety orientation
      1. Legacy content must be reconciled against current labeling and institutional policy before clinical use.
        Source IDH51-1AADE6961DDF54E09362F630
      Coverage path
      automatic_legacy_quick_reference
      Source IDH51-A818DE330D2A5E04D567C3FC
      Coverage path label
      Automatic legacy GlobalRPh quick reference
      Source IDH51-722E491CD16130FCA7AF9AA5
      Legacy title
      Streptokinase
      Source IDH51-F8ACAB81EB6A16151DF0688B
      Review note
      First-look orientation only. Verify indication, patient population, weight basis, organ function, exact IV product, dose, concentration, compatibility, rate, and current labeling before use.
      Source IDH51-E7A047584F9170248082D12F
      Search text
      Streptokinase Anticoagulation and hemostasis Legacy GlobalRPh directory entry Anticoagulation, platelet inhibition, thrombolysis, bleeding reversal, or coagulation-factor replacement, depending on the named agent. Forms a plasminogen activator complex that generates plasmin and produces systemic fibrinolysis. The existing GlobalRPh dose and preparation quick reference loads automatically below. Treat it as historical continuity, then confirm the exact current DailyMed label, population, indication, renal function, and institutional policy. Route, dilution, concentration, and administration details load automatically from the existing GlobalRPh quick reference below; current exact-product verification remains required. Renal dosing status has not been locally normalized; use the current package insert before ordering or administration. Legacy content must be reconciled against current labeling and institutional policy before clinical use. Automatic legacy GlobalRPh quick reference
      Source IDH51-9236FE586A9BF307DD8109FA
      Official access mode
      none
      Source IDH51-CC9A71B8B5512223EF8452B7
      Official access reason
      No source-backed DailyMed action has been verified for this umbrella or legacy record; identify the exact product before searching.
      Source IDH51-C04466BAD73C08F111393C95

      No separate structured rows were bundled for preparation, IV push, continuous infusion, population dosing, dialysis, CRRT. Historical article content and source links may cover these topics.

      Historical renal-function guidance

      Recovered v5.1 source content; historical, awaiting current review.

      Separate renal reference: Open Renal Dosing Master (opens in a new tab)
      Classification
      current_label_review_required
      Source IDH51-3B595E977961ECBA40EBEF14
      Summary
      Renal dosing status has not been locally normalized; use the current package insert before ordering or administration.
      Source IDH51-B79460E158D7A1E68C29A3D3
      Method note
      Use the renal function estimate and body-size convention specified by the selected label or institutional protocol. Do not interchange Cockcroft-Gault CrCl, indexed eGFR, and de-indexed eGFR without confirming the dosing source.
      Source IDH51-E0329D83F56E6CC0B9265995

      Historical Warnings and safeguards

      Recovered v5.1 source content; historical, awaiting current review.

      1. Legacy content must be reconciled against current labeling and institutional policy before clinical use.
        Source IDH51-FF5B0AA9EDA80B21183CDE4D

      Historical Stability notes

      Recovered v5.1 source content; historical, awaiting current review.

      1. Legacy product stability information is not automatically equivalent to a USP <797> BUD.
        Source IDH51-651E0783E6432ABD65077425
      Other recovered source fields and original editorial metadata

      Original status words such as current, verified, or normalized describe the historical source release. They do not change the clinical review status of this release.

      Catalog source fields

      Id
      streptokinase
      Source IDH51-87E9B3D676AE2930F6525FB5
      Legacy title
      Streptokinase
      Source IDH51-64DDB21A5854778987E50263
      Generic name
      Streptokinase
      Source IDH51-E7E999E55655E3DD3CED7ADC
      Class
      Anticoagulation and hemostasis
      Source IDH51-A8BCEC436526FE8B26C569A1
      Subclass
      Legacy GlobalRPh directory entry
      Source IDH51-F5DCDB12C077FDFDC540B69C
      Summary
      Existing GlobalRPh IV dilution monograph retained for migration into the unified reference.
      Source IDH51-8F3F17F9C88F7911E4549873
      Populations
      1. Population not yet normalized
        Source IDH51-62AF822370B1917CD39C2A73
      Evidence tier
      Legacy catalog - migration review required
      Source IDH51-DFE4FB0FCD181CB97823A5BF
      High alert
      false
      Source IDH51-77BAF07CF5038FD6840CF504
      Hazardous
      false
      Source IDH51-E85EA21DAADC1F19104E3C39
      Status
      Legacy migration
      Source IDH51-9E0B406CBAA224DB035078C3
      Version added
      Legacy
      Source IDH51-7782FC7112D2930E5D1E32B0
      Sources
      LabelUrlKind
      Source IDH51-5201613665D9108ED039E200
      GlobalRPh legacy IV dilution monograph
      Source IDH51-39F753FCBAE111A3D57C2C62
      legacy:auto
      Source IDH51-F0142544A406B0AEB8D4AD93
      Legacy
      Source IDH51-CB2C3D7767CC594B73A9A3F1
      Clinical release verification
      Audit version
      3.4
      Source IDH51-DD1C2D13D9088A5691D8370A
      Audited on
      2026-08-30
      Source IDH51-CC6E5C202F908E082D41D594
      Level
      red
      Source IDH51-343939E1F86CCA0E98F4AB7F
      Release gate
      unverified_or_unclassified_sources_do_not_release_as_current
      Source IDH51-87A7D41F04E246327AEBD055
      Exact current label candidate
      false
      Source IDH51-C9DFBB1A5960CFDD080F9E1C
      Reference url count
      0
      Source IDH51-97ED37A938EEFEDCEA2996D1
      Broken reference count
      0
      Source IDH51-57C215B00F05ECB4CE90004E
      Point of use confirmation required
      true
      Source IDH51-C3BBE5BC3EF275AA26702F6E
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-5AB4512189B1F612A8F69BB4

      Dosing source fields

      Id
      streptokinase
      Source IDH51-915DFA3636CBB32232133226
      Generic name
      Streptokinase
      Source IDH51-70A7EFBA1E002C3F87A97FA3
      Coverage status
      direct_official_label_access_plus_legacy_reference
      Source IDH51-4EF3AB02CE00756E7A2A0B3E
      Package insert
      Query name
      Streptokinase
      Source IDH51-154F80023EF0BBA24A90B3DD
      Product and route must match
      true
      Source IDH51-C079175D6AA3DEC9464E611D
      Live current label enabled
      false
      Source IDH51-9135CBC1A6D3E98B106B9499
      Source priority
      Reviewed local summary when available, then a verified DailyMed label or product search when available, followed by professional references and institutional policy.
      Source IDH51-8A4CAC9C2D0B22286A287C29
      Direct official label access enabled
      true
      Source IDH51-E8F2A96CE02C964216D8C7FA
      Outbound server request required
      false
      Source IDH51-A76DDC8341D69D796532A1BC
      Local summary status
      not_bundled
      Source IDH51-C5C0AE0C2E3F79A68D1BC553
      Clinical review
      Locally normalized
      false
      Source IDH51-DBEEE5F4277D194B885D2287
      Reviewed
      2026-08-29
      Source IDH51-4502EFF302EFA754C13FA132
      Status
      Direct official package-insert access enabled; indication-specific local normalization pending.
      Source IDH51-389BE678703375DE25FB96AF
      Clinical release verification
      Audit version
      3.4
      Source IDH51-6DEE452834DE64627E7F5F38
      Audited on
      2026-08-30
      Source IDH51-5B4B266A35849D018CE21E2D
      Level
      red
      Source IDH51-E1318CA747B78FE1000E3CD6
      Release gate
      unverified_or_unclassified_sources_do_not_release_as_current
      Source IDH51-67D86D12508DFA212218A9E0
      Exact current label candidate
      false
      Source IDH51-78804E24C578CC17AFA1398E
      Reference url count
      0
      Source IDH51-9745C08D051DA3B85DDACD75
      Broken reference count
      0
      Source IDH51-8ECFB4B39D5335454BEAD8F5
      Point of use confirmation required
      true
      Source IDH51-9EA37E76406E4C52E0FD6336
      Note
      Do not treat this record as a fully current product-specific monograph until the exact IV formulation and current sources are confirmed.
      Source IDH51-CDA10FD672D1FAD2E262035E
      Historical preparation assessment

      Recovered v5.1 source content; historical, awaiting current review.

      Id
      streptokinase
      Source IDH51-F88BC7C3E3F99497CE6F59E6
      Name
      Streptokinase
      Source IDH51-0969316B25B7159782313CCC
      Therapeutic class
      Anticoagulation and hemostasis
      Source IDH51-7F0E8AEA87F616EBE999E5A4
      Review version
      3.1
      Source IDH51-1F4EBEB46CC7F92DC035950D
      Review date
      2026-08-30
      Source IDH51-7E4C10C7F1D8594990B028B0
      Release status
      no_released_dilution_current_label_review_required
      Source IDH51-785FFC26481A60AD77EA3150
      Market status
      Status
      no_current_us_iv_spl_confirmed
      Source IDH51-29F15EFC7503A998376AF435
      Basis
      No high-confidence current IV SPL was automatically selected; legacy information is segregated
      Source IDH51-173B2A2E0F2CD111660BC14A
      Ten point assessment
      Exact formulation
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-C837CE48F2D6AC5406DB16F4
      Reconstitution concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-AD4ECC009EDD830BC05DC4C2
      Maximum or recommended final concentration
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-B5DCF427893382B7D1DDC284
      Appropriate standardized containers
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-1E42CC90E92A876FF4B72D07
      Adult dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-4E4C7B925E70DCF167522805
      Pediatric dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-38FDCDE27D740B6175B488D0
      Neonatal dosing range
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-9C1954D323F890AC1CC44474
      Infusion time
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-B7A0166744C21716C19D6B0B
      Fluid restriction alternatives
      Not established in the currently normalized record. Use the current-label panel before clinical use.
      Source IDH51-0B3B3C00652B5ACF94DEF0DF
      Current manufacturer labeling
      Match confidence
      unresolved
      Source IDH51-789320B082BA83542D4927A9
      Field provenance
      Exact formulation
      Primary
      not_found
      Source IDH51-32D15C094DF1780895F0D2A2
      Reconstitution concentration
      Primary
      not_found
      Source IDH51-52697C6B7046377C76493B6F
      Maximum or recommended final concentration
      Primary
      not_found
      Source IDH51-9AC2191E4CBE34880638C190
      Appropriate standardized containers
      Primary
      not_found
      Source IDH51-59FF73877FF852EE75DF1970
      Adult dosing range
      Primary
      not_found
      Source IDH51-4AF09EDC9AA900FE1787E8A5
      Pediatric dosing range
      Primary
      not_found
      Source IDH51-0E293D7C85BD128D65C692C6
      Neonatal dosing range
      Primary
      not_found
      Source IDH51-3F714766502DFFB2A6583E9F
      Infusion time
      Primary
      not_found
      Source IDH51-B4C42257109BFCF677EDC360
      Fluid restriction alternatives
      Primary
      not_found
      Source IDH51-6704D555ED9D3E845F6E3481
      Current manufacturer labeling
      Primary
      DailyMed search gateway
      Source IDH51-F9B8CBDB141777404B1DDB9F
      Population applicability
      Adult
      Applicability
      not_established
      Source IDH51-BE086299232C431DD527041A
      Guide generation allowed
      false
      Source IDH51-8C3D1664E6B80321E2EC003F
      Pediatric
      Applicability
      not_established
      Source IDH51-A02DFE52A7058FF42ACF1874
      Guide generation allowed
      false
      Source IDH51-B5FDF9A5B03D36F8D429D2B9
      Neonatal
      Applicability
      not_established
      Source IDH51-BAE3C79F2F6215642657356D
      Guide generation allowed
      false
      Source IDH51-F552D3B8018075823CFA0607
      Route presence
      Structured dilution
      false
      Source IDH51-804965EF6E1283DC3CCAD6EA
      Iv push
      false
      Source IDH51-4D05992BCB5758A207BDE383
      Continuous infusion
      false
      Source IDH51-0DEF791A706A8BAE28350FFC
      Pediatric source
      false
      Source IDH51-994C64AFFCC4CD1CDE27007D
      Neonatal source
      false
      Source IDH51-91E43FE24EE7EEB0834FAD00
      Legacy reference
      Status
      not_available
      Source IDH51-FFE3F6092FA38E0100D4FDAD
      Label resolution
      Status
      build_environment_network_unavailable
      Source IDH51-85D2768D149D9D605A8F704A
      Source files
      1. catalog.json
        Source IDH51-5976882ECEEF79AC64CD268A
      2. dosing.json
        Source IDH51-97FBCAA7C68DF01F918DD435
      3. legacy-map.json
        Source IDH51-A36E3A64BAFD114D5EEA53C7
      4. review-queue.json
        Source IDH51-7A9F0C2AD06685E5A2B21803
      Clinical release note
      Preparation instructions are released only at the evidence level shown. Legacy content remains visibly separate. Exact product, NDC, route, current labeling, and institutional policy must be confirmed.
      Source IDH51-9AB6136C98FBE836E081A04D
      Historical statement IDs and source locations

      These IDs identify recovered source units. They are not evidence-qualified clinical claims.

      Historical IDOriginal source locationStatus
      H51-87E9B3D676AE2930F6525FB5catalog.json
      /records/227/id
      Historical; current review incomplete
      H51-64DDB21A5854778987E50263catalog.json
      /records/227/legacy_title
      Historical; current review incomplete
      H51-E7E999E55655E3DD3CED7ADCcatalog.json
      /records/227/generic_name
      Historical; current review incomplete
      H51-A8BCEC436526FE8B26C569A1catalog.json
      /records/227/class
      Historical; current review incomplete
      H51-F5DCDB12C077FDFDC540B69Ccatalog.json
      /records/227/subclass
      Historical; current review incomplete
      H51-8F3F17F9C88F7911E4549873catalog.json
      /records/227/summary
      Historical; current review incomplete
      H51-FF5B0AA9EDA80B21183CDE4Dcatalog.json
      /records/227/warnings/0
      Historical; current review incomplete
      H51-651E0783E6432ABD65077425catalog.json
      /records/227/stability_notes/0
      Historical; current review incomplete
      H51-62AF822370B1917CD39C2A73catalog.json
      /records/227/populations/0
      Historical; current review incomplete
      H51-DFE4FB0FCD181CB97823A5BFcatalog.json
      /records/227/evidence_tier
      Historical; current review incomplete
      H51-77BAF07CF5038FD6840CF504catalog.json
      /records/227/high_alert
      Historical; current review incomplete
      H51-E85EA21DAADC1F19104E3C39catalog.json
      /records/227/hazardous
      Historical; current review incomplete
      H51-9E0B406CBAA224DB035078C3catalog.json
      /records/227/status
      Historical; current review incomplete
      H51-DE77BD97C08B9EA73330CB4Ccatalog.json
      /records/227/reviewed
      Historical; current review incomplete
      H51-7782FC7112D2930E5D1E32B0catalog.json
      /records/227/version_added
      Historical; current review incomplete
      H51-5201613665D9108ED039E200catalog.json
      /records/227/sources/0
      Historical; current review incomplete
      H51-39F753FCBAE111A3D57C2C62catalog.json
      /records/227/sources/0/label
      Historical; current review incomplete
      H51-F0142544A406B0AEB8D4AD93catalog.json
      /records/227/sources/0/url
      Historical; current review incomplete
      H51-CB2C3D7767CC594B73A9A3F1catalog.json
      /records/227/sources/0/kind
      Historical; current review incomplete
      H51-DD1C2D13D9088A5691D8370Acatalog.json
      /records/227/clinical_release_verification/audit_version
      Historical; current review incomplete
      H51-CC6E5C202F908E082D41D594catalog.json
      /records/227/clinical_release_verification/audited_on
      Historical; current review incomplete
      H51-343939E1F86CCA0E98F4AB7Fcatalog.json
      /records/227/clinical_release_verification/level
      Historical; current review incomplete
      H51-87A7D41F04E246327AEBD055catalog.json
      /records/227/clinical_release_verification/release_gate
      Historical; current review incomplete
      H51-C9DFBB1A5960CFDD080F9E1Ccatalog.json
      /records/227/clinical_release_verification/exact_current_label_candidate
      Historical; current review incomplete
      H51-A21572E5798E9C702A932723catalog.json
      /records/227/clinical_release_verification/selected_setid
      Historical; current review incomplete
      H51-7829D33025E425F950222F8Fcatalog.json
      /records/227/clinical_release_verification/selected_label_title
      Historical; current review incomplete
      H51-4F380A64018164D5BC15F1B4catalog.json
      /records/227/clinical_release_verification/numeric_support_ratio
      Historical; current review incomplete
      H51-97ED37A938EEFEDCEA2996D1catalog.json
      /records/227/clinical_release_verification/reference_url_count
      Historical; current review incomplete
      H51-57C215B00F05ECB4CE90004Ecatalog.json
      /records/227/clinical_release_verification/broken_reference_count
      Historical; current review incomplete
      H51-C3BBE5BC3EF275AA26702F6Ecatalog.json
      /records/227/clinical_release_verification/point_of_use_confirmation_required
      Historical; current review incomplete
      H51-5AB4512189B1F612A8F69BB4catalog.json
      /records/227/clinical_release_verification/note
      Historical; current review incomplete
      H51-0A35DE0A20E19FE6CA5D7477catalog.json
      /records/227/clinical_release_verification/dailymed_search_url
      Historical; current review incomplete
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