Searchable organism database
Browse current names and former taxonomy, clinically important resistance phenotypes, culture and diagnostic details, likely infections, MIC cautions, directed-therapy anchors, prevention, and public-health notes.
Disease and syndrome atlas
Start with a clinical syndrome, then review ranked bacterial causes, context modifiers, specimens, culture strategy, diagnostic cautions, empiric-treatment anchors, source control, red flags, and links back to organism profiles.
Multi-organism treatment coverage optimizer
Select cultured or suspected organisms. The engine searches stored complete regimen sets and ranks combinations that cover every eligible selection with the fewest agents, followed by narrower spectrum and preferred directed options.
1. Select up to eight organisms or phenotypes
2. Review selections and constraints
MIC and antimicrobial-susceptibility workspace
Document a raw MIC and the laboratory-reported category, then review organism-specific intrinsic resistance, MIC cautions, and current standard links. The application does not reproduce proprietary breakpoint tables or invent an interpretation.
Enter an isolate result
Organism context
Optional local breakpoint import
Expected JSON schema
{
"standard": "CLSI",
"version": "M100 Ed36",
"breakpoints": [
{
"organismId": "example-organism-id",
"drugId": "example-drug-id",
"method": "broth microdilution",
"site": "nonmeningitis",
"unit": "ug/mL",
"sMax": 1,
"iMin": 2,
"iMax": 2,
"rMin": 4
}
]
}Antimicrobial reference library
Review spectrum, route, AWaRe group, population-specific dosing availability, renal considerations, cautions, and the organism regimens that use each agent. Open the linked dosing reference for adult, pediatric, neonatal, non-dialysis renal, hemodialysis, or CRRT orientation.
Guidelines, standards, textbooks, and source library
Every profile is connected to dated sources. Current AST standards and treatment guidance are separated from broad textbook background so users can see which material is likely to change fastest.
Legacy-page clinical and taxonomy audit
The attached GlobalRPh pages were used as historical requirements and content examples. This register identifies high-value material that was preserved, renamed, corrected, separated into species-specific records, or removed because it could not be validated.
About the platform and V1.0-to-V1.6 review
Version 1.6 is a data-driven replacement for a collection of static organism pages and now includes a population-separated antimicrobial dosing reference. The platform retains the original clinical intent while making taxonomy, evidence dates, disease links, AST cautions, and maintenance explicit.
What is included
- Searchable organism and resistance-phenotype profiles with current names and legacy aliases.
- Independent classifications for Gram reaction, morphology, oxygen requirement, functional group, taxonomy, reservoir, and transmission.
- Culture, specimen, diagnostic, MIC, intrinsic-resistance, resistance-mechanism, treatment, prevention, infection-control, biosafety, and public-health fields.
- A disease atlas that ranks pathogens by syndrome and context, links bidirectionally to organism profiles, and opens complete empiric-treatment scenarios.
- A separate empiric therapy module with setting, severity, resistance-risk, diagnostic, source-control, duration, monitoring, and de-escalation branches.
- A population-separated dosing reference for adults, pediatric patients, and neonates, plus adult non-dialysis renal, intermittent hemodialysis, and CRRT orientation. Missing pediatric or neonatal data never fall back to an adult dose.
- A regimen-set coverage optimizer that searches for complete coverage with the fewest eligible agents.
- An MIC workspace that refuses to invent a breakpoint and supports optional local version-controlled data.
- Guideline, textbook, PubMed-search, and NCBI-taxonomy links plus a transparent legacy audit.
Scope and important limits
This is a broad clinician-facing seed database, not an exhaustive catalogue of every validly published bacterial species, subspecies, strain, resistance determinant, or regional syndrome. Aggregate records are used where species-level management is usually driven by the syndrome and susceptibility result. Rare and high-consequence organisms are flagged for reference-laboratory, public-health, or specialist review.
The coverage optimizer minimizes stored regimen sets, not patient harm. Fewer agents are not always safer or more appropriate; combination therapy may be required for synergy, resistance prevention, toxin suppression, or a protected site. Conversely, a broad single agent may be less desirable than two narrow agents. The result therefore displays stewardship scoring and required verification rather than a single directive.
V1.0 review findings and V1.6 improvements
Recommended editorial maintenance cycle
- Check CLSI M100, EUCAST tables, IDSA AMR guidance, FDA safety or labeling changes, CDC public-health guidance, and major society guidelines at least annually and after high-impact interim updates.
- Update the source record first, then organism, disease, antimicrobial, and legacy-audit records that depend on it.
- Run schema, cross-link, duplicate-ID, regimen-ID, source-ID, PHP, JavaScript, accessibility, and browser smoke tests before deployment.
- Retain old names as aliases and document clinically meaningful changes rather than silently overwriting history.