GlobalRPh Clinical Infectious DiseasesBacterial Pathogen Database and Empiric Therapy Platform
Version 1.6
Empiric Antimicrobial Therapy and Population-Specific Dosing Explorer
Start with a suspected infection, search the complete scenario library, or open a standalone antimicrobial dosing record. Every regimen and dose is labeled for an adult, pediatric, neonatal, or mixed population. Adult doses are never substituted for children or neonates.
Clinical-use boundary: Empiric therapy is a time-limited hypothesis, not a final diagnosis. Stabilize critical illness, obtain appropriate cultures when feasible, complete source control, use the current local antibiogram and formulary, and perform an antibiotic timeout within 24 to 72 hours. The stored doses are orientation references. Patient-specific prescribing still requires confirmation of the indication, age, weight, postmenstrual and postnatal age when applicable, kidney and hepatic function, allergy phenotype, pregnancy, interactions, infusion strategy, therapeutic drug monitoring, and institutional policy.
Start here
Choose the workflow that matches your question
The two treatment sections serve different purposes. They use the same underlying evidence records, but they do not perform the same task.
Workflow A
Guided Scenario Finder
Use this when the suspected infection or syndrome is already known.
Review ranked stored clinical branches and their warnings.
Open the matching branch for diagnostics, likely pathogens, complete empiric regimen components, dosing, source control, duration, monitoring, and de-escalation.
Use this when the disease name is uncertain, when several related branches must be compared, or when searching by pathogen, body site, drug, setting, population, or resistance concern.
Search all 507 stored scenarios at once.
Filter by category, setting, severity, population, dosing completeness, treatment status, and evidence year.
Save favorites, compare up to three branches, and export filtered results.
Open any branch for the same complete clinical detail available in the guided finder.
Separate supporting tool: The standalone Dosing and Renal Reference does not choose an infection pathway. It starts with a drug and then displays only the selected adult, pediatric, or neonatal dose table plus the selected kidney-function context.
Select a known disease, then refine the clinical frame. The finder ranks complete stored branches. It does not diagnose the patient or declare a universally best regimen.
Decision support, not prescribing
1. Define the clinical frame
Choose the best matching syndrome before adding modifiers.
Population will be inferred after a disease is selected.
Adult renal tables are suppressed for pediatric and neonatal patients.
2. Review ranked stored scenarios
How ranking works: Exact disease match dominates, followed by population, setting, severity, resistance tags, local preference, and visible safety warnings. A high score does not establish safety or appropriateness for a specific patient.
Search the entire scenario library by infection, body site, organism, antimicrobial, setting, severity, population, or resistance concern. This section does not rank one disease-specific set unless you filter it to a single disease.
Standalone Antimicrobial Dosing and Renal Reference
Use this section when the drug is already known. It does not select empiric therapy. Select the patient population first, then choose the kidney-function context. Missing pediatric or neonatal data never trigger an adult fallback.
81 linked dosing records
Population definitions: Pediatric generally refers to patients beyond the neonatal period, but individual records may use a different age scope. Neonatal records may depend on both postmenstrual age and postnatal age. Read the age scope shown with every drug.
Import a browser-local JSON policy to mark preferred or hidden scenarios, add stewardship notes, and display formulary status. The imported file does not rewrite the distributed clinical data.
Import local policy
No local policy loaded.
Supported controls and safeguards
Preferred, hidden, or retired scenario IDs
Scenario-specific stewardship notes
Formulary status by antimicrobial ID
Institution name, policy version, effective date, expiration date, and reviewer
Local antibiogram comments for clinician review
Safeguard: The policy import does not calculate susceptibility, create dosing, or override a population warning.
Guidelines, Standards, Labels, Texts, and Journal Sources
Search the dated source library. Treatment-guidance freshness is tracked separately from AST, diagnostic, laboratory, or product-label publication years.