GlobalRPh Renal Dosing Masterv7.4
Renal Dosing Master: fast drug lookup
Updated November 7, 2026 | v7.4

Renal updates by clinical finding

Search 237 product updates by drug, renal measure or dialysis term. Each result identifies the formulation, the label used and the limits of its renal guidance.

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Search all 1,215 records | Source cautions

Dose or interval change

Lamotrigine (Lamictal XR), oral extended-release tablet

Renal measure
Renal impairment categories as defined by the cited product label
Renal action or finding
Select the initial lamotrigine schedule from the concomitant antiseizure regimen. Significant renal impairment may permit a lower maintenance dose.
Limits and monitoring
Verify the release form. Titration and restarting precautions remain essential because of serious rash risk.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 44, posted Aug 20, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Lenalidomide (Revlimid), oral capsule

Renal measure
Cockcroft-Gault CrCl, mL/min
Renal action or finding
Choose the starting dose from the Cockcroft-Gault CrCl table for the exact indication. Separate columns cover combination therapy, post-transplant maintenance or MDS, and follicular or marginal-zone lymphoma.
Limits and monitoring
Dialysis has a separate row with dosing after the session on dialysis days. Verify cycle days and blood counts before applying a schedule.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 41, posted Aug 06, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Levetiracetam (Keppra), adult oral immediate-release

Renal measure
CrCl normalized to 1.73 m2, mL/min/1.73 m2
Renal action or finding
Adult immediate-release oral dosing uses CrCl adjusted to 1.73 m2. The dialysis row gives 500-1,000 mg every 24 hours and an additional 250-500 mg after dialysis.
Limits and monitoring
Use the labeled table for the other clearance bands. The XR and injection products have separate source records.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 36, posted Jan 29, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Levetiracetam (Roweepra), oral tablet

Renal measure
CrCl normalized to 1.73 m2, mL/min/1.73 m2
Renal action or finding
Use body-surface-area-adjusted CrCl to select the adult oral levetiracetam dose. Hemodialysis requires a supplemental dose after the session.
Limits and monitoring
Use the renal table for the exact oral product. Confirm the tablet strength and dosing interval.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 5, posted May 26, 2025 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Levetiracetam (Spritam), oral tablet for suspension

Renal measure
CrCl normalized to 1.73 m2, mL/min/1.73 m2
Renal action or finding
Use body-surface-area-adjusted CrCl to select the adult oral levetiracetam dose. Hemodialysis requires a supplemental dose after the session.
Limits and monitoring
Use the renal table for the exact oral product. Confirm the tablet strength and dosing interval.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 29, posted Nov 17, 2025 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Methotrexate (Otrexup), subcutaneous injection

Renal measure
Renal impairment categories as defined by the cited product label
Renal action or finding
Renal dysfunction reduces methotrexate elimination. Monitor closely for toxicity and reduce the dose or discontinue when indicated.
Limits and monitoring
Verify the once-weekly subcutaneous autoinjector, prescribed strength and indication.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 15, posted Feb 03, 2025 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Methotrexate (Rasuvo), subcutaneous injection

Renal measure
Renal impairment categories as defined by the cited product label
Renal action or finding
Renal dysfunction reduces methotrexate elimination. Monitor closely for toxicity and reduce the dose or discontinue when indicated.
Limits and monitoring
Verify the once-weekly subcutaneous autoinjector, prescribed strength and indication.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 10, posted Dec 18, 2025 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Oxcarbazepine (Trileptal), oral tablet

Renal measure
Creatinine clearance (CrCl), mL/min
Renal action or finding
For adult CrCl below 30 mL/min, start immediate-release oxcarbazepine at 300 mg per day in two divided doses. Titrate slowly to response.
Limits and monitoring
This is half the usual adult starting dose. Confirm the preparation and monitor tolerability and serum sodium when indicated.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 40, posted Oct 30, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Silodosin (Rapaflo), oral capsules

This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.

Renal measure
Creatinine clearance (CrCl), mL/min
Renal action or finding
The label lists silodosin 4 mg once daily with a meal for moderate impairment (CrCl 30-50 mL/min) and contraindicates use below 30.
Limits and monitoring
The cited mild (50-80) and moderate (30-50) ranges both print 50. At exactly 50 verify the current product label and clinical interpretation before choosing a dose.

Both printed ranges include CrCl 50 mL/min. Verify the boundary in current prescribing information.

DailyMed SPL version 3, posted Feb 28, 2012 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Sotalol hydrochloride (Betapace), oral tablet

Renal measure
Creatinine clearance (CrCl), mL/min
Renal action or finding
In renal impairment select the interval by CrCl, monitor heart rate and QTc, and allow at least five doses at the appropriate interval before increasing the dose.
Limits and monitoring
Use the full initiation or reinitiation protocol. Hemodialysis removes some drug but the label supplies no dialysis regimen.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 2, posted Dec 20, 2024 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Tacrolimus (Prograf), immediate-release oral or IV; verify route

Renal measure
Renal impairment categories as defined by the cited product label
Renal action or finding
In recipients of a liver, heart or lung transplant with pre-existing renal impairment, consider the low end of the tacrolimus therapeutic dose range because of nephrotoxicity.
Limits and monitoring
Check trough concentrations, kidney function, route and transplant indication.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 30, posted Mar 21, 2025 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Tenofovir disoproxil fumarate (Viread), oral tablet

Renal measure
Creatinine clearance (CrCl), mL/min
Renal action or finding
For the adult 300 mg TDF tablet, increase the interval when CrCl falls below 50 mL/min. The 50-80 mL/min group needs no renal adjustment.
Limits and monitoring
No regimen is established below 10 mL/min without HD or for children with renal impairment. Use the separate HD row and monitor renal toxicity.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 31, posted Feb 24, 2025 | Selected sections checked 2026-11-07. Independent clinical review pending.

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