Search 237 product updates by drug, renal measure or dialysis term. Each result identifies the formulation, the label used and the limits of its renal guidance.
Cockcroft-Gault CrCl with actual body weight, mL/min
Renal action or finding
Initial oral doses by calculated CrCl are 500 mcg twice daily above 60, 250 mcg twice daily at 40-60, and 125 mcg twice daily at 20 to below 40 mL/min. Below 20, use is contraindicated.
Limits and monitoring
Initiate or reinitiate with inpatient continuous ECG monitoring for at least three days. Follow the label's baseline and post-dose QT algorithm, interaction exclusions, and electrolyte checks.
For adult hypertension with CrCl 30 mL/min or less, the recommended first oral enalapril dose is 2.5 mg once daily. Above 30, the usual initial regimen applies.
Limits and monitoring
Dialysis days, heart failure, baseline hypotension and diuretic use have separate considerations.
For immunocompetent adults with herpes zoster, use 500 mg every 8 hours at CrCl at least 60, every 12 hours at 40-59, and every 24 hours at 20-39 mL/min. Below 20, give 250 mg every 24 hours. In HD give 250 mg following each dialysis session.
Limits and monitoring
The usual course is seven days. Genital and orolabial herpes use different regimens. The primary source is a matched generic oral tablet label.
Select maintenance and induction doses from the indication-specific table using CrCl in mL/min/kg. Measure renal function frequently, adjust when it changes, and provide labeled hydration.
Limits and monitoring
An absolute CrCl in mL/min cannot be entered directly into this table. Monitor calcium, magnesium, potassium and phosphate.
Adult CrCl below 90 mL/min requires a lower imipenem/cilastatin IV regimen. Use the label's renal table and the row for the intended regimen and organism susceptibility.
Limits and monitoring
Use stable serum creatinine. The label restricts use below CrCl 15 unless hemodialysis is instituted within 48 hours. Confirm seizure risk and HD timing.
For HIV treatment in adults and adolescents at least 25 kg, reduce lamivudine dosing below CrCl 50 mL/min. At 30-49 mL/min give 150 mg daily; lower bands have distinct first and maintenance doses.
Limits and monitoring
Routine four-hour HD or peritoneal dialysis requires no additional dose. Use the HIV product's renal table, not the HBV product regimen.
