Search 237 product updates by drug, renal measure or dialysis term. Each result identifies the formulation, the label used and the limits of its renal guidance.
Serum creatinine (mg/dL), age (years) and weight (kg)
Renal action or finding
For adult nonvalvular AF, use 2.5 mg twice daily when at least two are present: age 80 years or older, body weight 60 kg or less, or serum creatinine at least 1.5 mg/dL.
Limits and monitoring
The AF criteria do not determine the adult VTE regimen. Dialysis patients were excluded from efficacy trials and dialysis recommendations rely on exposure data.
For adults with CrCl below 30 mL/min, use immediate-release apremilast. Give only the morning doses during titration and use 30 mg once daily for maintenance.
Limits and monitoring
The XR formulation is not recommended in severe renal impairment. Children have separate weight-specific instructions.
For oral atenolol, the label caps the daily dose at 50 mg when indexed CrCl is 15-35 mL/min/1.73 m2 and at 25 mg below 15. Some patients with hypertension need a 25 mg initial dose.
Limits and monitoring
The HD instruction is a separate, supervised postdialysis regimen because marked hypotension can occur. This source addresses oral tablets.
Adults with COVID-19 receive 2 mg daily at eGFR 30 to below 60 and 1 mg daily at 15 to below 30. Use is not recommended below 15, with ESRD or dialysis, or in acute kidney injury.
Limits and monitoring
RA and alopecia areata use different renal rules. Neither indication uses the COVID-19 severe-impairment regimen.
This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.
Renal measure
Creatinine clearance (CrCl), mL/min
Renal action or finding
Use the usual adult dose and interval at CrCl 60 mL/min or greater. Below that value use the table for the specified presentation and suspension concentration.
Limits and monitoring
Conventional hemodialysis and peritoneal dialysis remove little cefixime. Check the exact formulation when a reduced dose is needed.
Adult IV ceftaroline doses every 12 hours are 400 mg at CrCl above 30 through 50, 300 mg at 15 through 30, and 200 mg below 15 mL/min, including ESRD on HD. Administer after HD on dialysis days.
Limits and monitoring
The pediatric table uses a different renal metric. Confirm the patient's age, indication and infusion instructions.
This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.
Renal measure
Creatinine clearance (CrCl), mL/min
Renal action or finding
Reduce maintenance dosing for impaired renal elimination. Select dose and interval using the adult renal table, the infection severity, and the organism's susceptibility.
Limits and monitoring
Excess exposure may cause encephalopathy, myoclonus or seizures. Verify the relevant dialysis schedule separately.
For adults use the IV label's renal table when CrCl is below 50 mL/min. Select dose and interval for the indication and phase of treatment; use the HD instructions on dialysis days.
Limits and monitoring
Pediatric adjustments use indexed eGFR and age-specific criteria. Confirm ceftobiprole medocaril sodium versus active ceftobiprole when reading doses.
For adults at CrCl below 30 mL/min, including HD or CAPD, give the indication-specific dose every 48 hours: 4 mg/kg for complicated skin infection or 6 mg/kg for S. aureus bacteremia. Dose after HD when feasible.
Limits and monitoring
At CrCl at least 30 the usual interval is 24 hours. Monitor renal function and CPK more frequently in renal impairment.
