Updated November 7, 2026 | v7.3
Renal updates by clinical finding
Search 90 products by drug, renal measure or dialysis term. Each result identifies the formulation, the label used and the limits of its renal guidance.
Search all 1,215 records | Source cautions
Dose or interval change
This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.
Renal measure Creatinine clearance (CrCl), mL/min; use the product-specific calculation Renal action or finding At CrCl 10-30 mL/min, use 2 mg once daily. Below 10 mL/min, use is not recommended because this population was not studied. Limits and monitoring Confirm the LA capsule and check CYP3A4 inhibitors. Immediate-release tablets have a different schedule. Review 1 product or source caution
Verify the current prescribing information for this presentation.
DailyMed SPL version 1, effective 2017-03-23; posted Apr 11, 2017 | Selected sections checked 2026-11-07. Independent clinical review pending.
Dose or interval change
Renal measure Cockcroft-Gault CrCl using ideal body weight, mL/min Renal action or finding Use Cockcroft-Gault with ideal body weight. At CrCl 30-49 mL/min, give 1.5 mg/m2/day; below 30, give 0.6 mg/m2/day. Both are on days 1-5 of the 21-day oral cycle. Limits and monitoring Use the oral dose-modification table. Verify blood-count recovery before the next cycle. IV topotecan uses different doses. Review 1 product or source caution
The primary label table includes 49 mL/min in the 30-49 band; section 8.6 also uses the words less than 49. At this boundary verify section 2.3 of the exact capsule label.
DailyMed SPL version 1, effective 2023-09-18; posted Oct 31, 2024 | Selected sections checked 2026-11-07. Independent clinical review pending.
Dose or interval change
This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.
Renal measure Creatinine clearance (CrCl), mL/min; use the product-specific calculation Renal action or finding For CrCl below 30 mL/min, start at 0.5 mg daily. Adjust subsequently according to response. Limits and monitoring Reduced clearance also occurs in dialysis. The selected section does not give a replacement dose after dialysis. Review 1 product or source caution
Verify the current prescribing information for this presentation.
DailyMed SPL version 2, effective 2012-02-14; posted Feb 15, 2012 | Selected sections checked 2026-11-07. Independent clinical review pending.
Pharmacokinetics only
Renal measure Indexed GFR/eGFR, mL/min/1.73 m2 Renal action or finding At eGFR 30-89 mL/min/1.73 m2, the PK analysis found no clinically meaningful change in exposure. Limits and monitoring Severe renal impairment, ESRD and dialysis were unstudied. The PK finding supplies no regimen for these groups. Review 1 product or source caution
Apply only to the stated formulation, indication and renal population.
DailyMed SPL version 3, effective 2025-08-31; posted Sep 10, 2025 | Selected sections checked 2026-11-07. Independent clinical review pending.
Dose or interval change
Renal measure Creatinine clearance (CrCl), mL/min; use the product-specific calculation Renal action or finding For CrCl 30 to below 50 mL/min, start at 200 mg once daily. Below 30, use is not recommended. Limits and monitoring Monitor QT closely. Dialysis-dependent patients were not studied. Review 1 product or source caution
Apply only to the stated formulation, indication and renal population.
DailyMed SPL version 15, effective 2026-10-30; posted Nov 04, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.
No adjustment within stated limits
Renal measure Cockcroft-Gault creatinine clearance, mL/min Renal action or finding At CrCl >=15 mL/min, a renal dose change is unnecessary. Monitor for adverse reactions in patients on dialysis. Limits and monitoring The effect of dialysis on drug exposure is unknown. Verify the exact dosage form. Review 1 product or source caution
Apply only to the stated formulation, indication and renal population.
DailyMed SPL version 25, effective 2026-09-04; posted Sep 14, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.
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