GlobalRPh Renal Dosing Masterv7.4
Renal Dosing Master: fast drug lookup
Updated November 7, 2026 | v7.3

Renal updates by clinical finding

Search 90 products by drug, renal measure or dialysis term. Each result identifies the formulation, the label used and the limits of its renal guidance.

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Search all 1,215 records | Source cautions

Dose or interval change

Paroxetine (Paxil CR), adult controlled-release oral tablets

Renal measure
Clinical renal category or population named in the cited section
Renal action or finding
In severe renal impairment, start at 12.5 mg/day. Titrate in 12.5 mg/day steps at weekly or longer intervals as indicated. Maximum daily doses are 50 mg for major depression or panic disorder, 37.5 mg for social anxiety disorder and 25 mg for PMDD.
Limits and monitoring
Confirm the indication and release form before applying a ceiling. Review the PMDD dosing schedule separately.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 34, effective 2026-09-30; posted Oct 02, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Monitoring or toxicity

PEG 3350/electrolytes/ascorbate (Plenvu), adult oral bowel preparation

Renal measure
Clinical renal category or population named in the cited section
Renal action or finding
In renal impairment, use with caution and maintain hydration before, during and after bowel preparation. Consider pre-dose and post-colonoscopy electrolytes, creatinine and BUN.
Limits and monitoring
Review diuretics, ACE inhibitors, ARBs and NSAIDs that can increase risk of renal injury. This source gives monitoring guidance rather than a renal dose table.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 14, effective 2023-09-01; posted Aug 11, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Restriction or avoidance

Pemetrexed (Alimta), IV lyophilized powder, adults

Renal measure
Cockcroft-Gault creatinine clearance, mL/min
Renal action or finding
Withhold if CrCl is below 45 mL/min. Recheck CrCl before each dose. At 45-79, avoid ibuprofen during the two days before treatment, treatment day and two days afterward.
Limits and monitoring
If ibuprofen cannot be withheld, increase monitoring for marrow suppression, renal injury and GI toxicity.

The U.S. labeling directs withholding below CrCl 45. The dated Ontario monograph instructs discontinuation below that threshold. Verify the applicable treatment protocol before deciding whether treatment may resume.

DailyMed SPL version 59, effective 2023-05-19; posted Jun 28, 2023 | Selected sections checked 2026-11-07. Independent clinical review pending.

Restriction or avoidance

Pemetrexed (Pemfexy), IV solution for dilution, adults

Renal measure
Cockcroft-Gault creatinine clearance, mL/min
Renal action or finding
Withhold at CrCl below 45 mL/min. At 45-79, withhold ibuprofen for the two days preceding the dose, the treatment day and the following two days.
Limits and monitoring
Check CrCl before every cycle. If ibuprofen is necessary, monitor hematologic, renal and GI toxicity more frequently.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 2, effective 2026-06-18; posted Jun 23, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Perindopril erbumine (Aceon), adult oral tablets

This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.

Renal measure
Creatinine clearance (CrCl), mL/min; use the product-specific calculation
Renal action or finding
Below CrCl 30 mL/min, use is not recommended. For less severe renal impairment, start at 2 mg/day and limit the total to 8 mg/day.
Limits and monitoring
This is the erbumine salt. Check blood pressure, renal function and potassium during treatment.

Verify the current prescribing information for this presentation.

DailyMed SPL version 3, effective 2013-03-11; posted Mar 20, 2013 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Phentermine (Adipex-P), oral tablets for obesity

Renal measure
Indexed GFR/eGFR, mL/min/1.73 m2
Renal action or finding
At eGFR 15-29, limit the total to 15 mg per day. Avoid use below 15 or in dialysis-dependent ESRD.
Limits and monitoring
The cutoff uses mL/min/1.73 m2. Apply it only to the specified phentermine product. The labeled tablet contains 37.5 mg; verify an available strength that can deliver the prescribed renal dose.

Apply only to the stated formulation, indication and renal population.

Prescribing information revised 3/2024 | Selected sections checked 2026-11-07. Independent clinical review pending.

Restriction or avoidance

Pioglitazone/metformin (Actoplus Met), adult conventional oral tablets

Renal measure
eGFR, mL/min as printed in the dosage subsection; indexing not specified there
Renal action or finding
The renal subsection discourages initiation at eGFR 30-45. During treatment, reassess below 45 and discontinue below 30, where use is contraindicated.
Limits and monitoring
The selected dosage subsection prints mL/min. Check the metric against the exact label before applying the cutoff and review heart failure risk.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 28, effective 2026-08-21; posted Aug 24, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Pirtobrutinib (Jaypirca), adult oral tablets

Renal measure
eGFR, mL/min as printed in the dosage subsection; indexing not specified there
Renal action or finding
At eGFR 15-29 mL/min: reduce 200 mg daily to 100 mg daily. For other current doses, lower by 50 mg daily; discontinue if already taking 50 mg daily. At 30-89 there is no renal change.
Limits and monitoring
Use the current dose and the eGFR units as printed in the label. The selected bands do not establish a dialysis regimen.

Apply only to the stated formulation, indication and renal population.

DailyMed SPL version 16, effective 2026-10-02; posted Oct 19, 2026 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Plerixafor (Mozobil), adult subcutaneous injection for stem-cell mobilization

Renal measure
Cockcroft-Gault creatinine clearance, mL/min
Renal action or finding
At CrCl <=50 mL/min and weight <=83 kg, use 13 mg or 0.16 mg/kg once daily. For weight >83 to <160 kg, use 0.16 mg/kg once daily, maximum 27 mg/day.
Limits and monitoring
Verify actual weight and mobilization timing. The table stops before 160 kg and the label gives no hemodialysis dose recommendation.

BC Cancer specifies a renal weight-based regimen at CrCl 20-50 and provides no dose below 20 or on dialysis. Check the U.S. label and local transplant protocol separately.

DailyMed SPL version 24, effective 2025-09-22; posted Sep 25, 2025 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Pramipexole (Mirapex ER), adult once-daily extended-release tablets

This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.

Renal measure
Creatinine clearance (CrCl), mL/min; use the product-specific calculation
Renal action or finding
At CrCl 30-50 mL/min, start with 0.375 mg every other day. After one week, consider daily dosing according to response and tolerance. Further increases are by 0.375 mg at intervals of at least one week, up to 2.25 mg/day.
Limits and monitoring
ER use is not recommended below 30 mL/min or on hemodialysis. Confirm the release form before prescribing.

Verify the current prescribing information for this presentation.

Prescribing information revised 6/2024 | Selected sections checked 2026-11-07. Independent clinical review pending.

No adjustment within stated limits

Regadenoson (Lexiscan), adult IV pharmacologic stress agent

This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.

Renal measure
Clinical renal category or population named in the cited section
Renal action or finding
Renal impairment, including ESRD or dialysis dependence, does not require dose adjustment.
Limits and monitoring
Applies to the diagnostic stress-agent injection. Follow the full protocol for administration and monitoring.

Verify the current prescribing information for this presentation.

DailyMed SPL version 13, effective 2018-12-21; posted Jan 29, 2019 | Selected sections checked 2026-11-07. Independent clinical review pending.

Dose or interval change

Repaglinide (Prandin), adult oral tablets for type 2 diabetes

This summary uses the identified dated label. Verify the current label for this presentation before applying the regimen.

Renal measure
Creatinine clearance (CrCl), mL/min; use the product-specific calculation
Renal action or finding
At CrCl 20-40 mL/min start with 0.5 mg before each meal. Titrate gradually to glucose response.
Limits and monitoring
There are no study data for CrCl below 20 or hemodialysis in this source. Skip the dose when a meal is skipped.

Verify the current prescribing information for this presentation.

DailyMed SPL version 5, effective 2017-12-28; posted Dec 28, 2017 | Selected sections checked 2026-11-07. Independent clinical review pending.

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