GlobalRPh Renal Dosing Masterv7.4
Renal Dosing Master: fast drug lookup
Product-specific reference

Zolpidem - AMBIEN CR extended-release tablets

Read renal action and limits
Local official-label summarySource retrieved 2026-11-07See the evidence for this drug2 sources available - open source summaries, references and comparisons

AMBIEN CR / zolpidem extended release / zolpidem ER

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Renal guidance at a glance

Cautions / source differences (1)
Review first - source-specific qualification

CR guidance rests on another formulation study

The renal conclusion is based on immediate-release data, not a direct CR study. The studied dose must not become a CR regimen.

Before applying: Confirm extended-release product and usual label safety/dosing factors before use.

Evidence for this qualification

Selected-source comparison; independent clinician adjudication pending.

Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist

Choose a source to read (2)

Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

Official source

AMBIEN CR: renal conclusion is extrapolated from immediate-release data

This source only - not a merged recommendation

What matters first

Product: Adult oral AMBIEN CR extended-release tablets. Not immediate-release or sublingual zolpidem; usual dosing and safety restrictions still apply.

Renal action / finding
Label: no renal adjustment; CR-specific renal study was not performed.
Evidence or dialysis limit
Not hemodialyzable does not supply a new supplemental-dose regimen.
Monitoring / application
Do not transfer the immediate-release study dose to CR; retain sedative safety restrictions.

Selected-section summary, not a complete monograph. Independent clinician review remains pending. Read the exact renal measure, dates and full source below.

Product / population
Adult oral AMBIEN CR extended-release tablets. Not immediate-release or sublingual zolpidem; usual dosing and safety restrictions still apply.
Renal measure
Renal conclusion supported by an immediate-release ESRD/hemodialysis study
Source revision
08/2024
Retrieved
2026-11-07 (not the revision date)
Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.
Before using this finding

Not hemodialyzable does not supply a new supplemental-dose regimen.

Section 12.3, renal impairment; boxed warning context

The label states that renal dose adjustment is not necessary, but AMBIEN CR was not directly studied in renal impairment. The supporting study used immediate-release zolpidem in 11 patients with ESRD receiving hemodialysis. Zolpidem was not hemodialyzable. The historical immediate-release study dose is not a CR prescribing recommendation. Age, sex, hepatic status, next-day impairment and the boxed complex-sleep-behavior warning remain relevant despite the renal conclusion.

Source revision: 08/2024 | Retrieved: 2026-11-07. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d934da3-bd77-4470-e063-6294a90a64f5

Scope: Selected named sections summarized; not a complete monograph or independent clinician approval. GlobalRPh v7.4.

Full source card / provenance

All sources, comparison tools and evidence navigation
Source-specific interpretation

What the dialysis evidence actually supports

Removal information alone does not define a maintenance dose, supplemental dose or dialysis schedule. A reported regimen still requires its product, indication, renal measure and dialysis assumptions to match the patient.

AMBIEN CR: renal conclusion is extrapolated from immediate-release data

Source retrieved 2026-11-07 - confirm current applicability

Removal information only - not a dialysis regimen

Read the source and its limits

AMBIEN CR: selected renal study limitations

Source retrieved 2026-11-07 - confirm current applicability

Removal information only - not a dialysis regimen

Read the source and its limits

These manual classifications apply only to the identified selected sections, not every retained source or the entire prescribing information. They are not dosing clearance.

Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 1 source difference / applicability notes

Official product label

AMBIEN CR: renal conclusion is extrapolated from immediate-release data

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.
Before using this finding

Not hemodialyzable does not supply a new supplemental-dose regimen.

Dialysis evidence: Removal information only - not a dialysis regimen

Adult oral AMBIEN CR extended-release tablets. Not immediate-release or sublingual zolpidem; usual dosing and safety restrictions still apply.

Renal method: Renal conclusion supported by an immediate-release ESRD/hemodialysis study
Retrieved: 2026-11-07

Read local renal resultOpen this source quick answerOpen original reference
GlobalRPh RX List

AMBIEN CR: selected renal study limitations

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.
Before using this finding

Confirm product, indication, renal measure and dialysis modality before applying.

Dialysis evidence: Removal information only - not a dialysis regimen

Adult oral AMBIEN CR extended-release tablets. Not immediate-release or sublingual zolpidem; usual dosing and safety restrictions still apply.

Renal method: Immediate-release ESRD/HD study supporting CR label conclusion
Retrieved: 2026-11-07

Read local renal resultOpen this source quick answerOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Product / population check

Confirm the exact formulation before using a renal source

These links compare product identities, not interchangeable doses. A selected summary is not a complete prescribing monograph.

Source-specific review points

CR guidance rests on another formulation study

Read the attributed comparison notes and source cards below. No conflict has been silently adjudicated.

Source-quality holds
Find text within this drug
Find a term without leaving this drug

Search the stored clinical text

Locate a word or phrase within this drug's source summaries. Choose all sources or one source to focus the search. The selection never hides warnings or source text, changes a dose, or proves that a renal finding is absent.

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All source summaries, original wording and provenance
Before applying a renal protocol

Check the setting. Compare whole sources.

No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.

Share a reproducible source review

Choose sources below, then open a print-ready comparison with product scope, renal method, dates and cautions. Links can pin the exact local cards; they never contain patient values or choose a dose.

Open / share selected sources
Jump to renal guidanceRead 1 difference / caution notesClinician guide

Select two distinct source versions. The complete stored summaries will appear below.

Build a source-review outline for documentation

This creates a blank decision outline with the source identities you select, not a dose recommendation or completed clinical assessment. No patient fields are collected, saved or sent. Complete the clinical decisions in your approved documentation system.

Choose one or two sources above or use the source checkboxes below.

Renal-context checklist: population, kidney trend and dialysis

These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.

Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.

See source-specific renal methods and the clinical interpretation guide for the supporting context.

Read before choosing a regimen

Source differences and product cautions

Search differences across all drugs

These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

Source scope / renal recommendation differences

CR guidance rests on another formulation study

The renal conclusion is based on immediate-release data, not a direct CR study. The studied dose must not become a CR regimen.

How to use this: Confirm extended-release product and usual label safety/dosing factors before use.

AMBIEN CR: renal conclusion is extrapolated from immediate-release dataAMBIEN CR: selected renal study limitations

Selected-source comparison; independent clinician adjudication pending.

Go directly to the relevant source section

Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Rxlist source

AMBIEN CR: selected renal study limitations

Adult oral AMBIEN CR extended-release tablets. Not immediate-release or sublingual zolpidem; usual dosing and safety restrictions still apply.

Method: Immediate-release ESRD/HD study supporting CR label conclusion

Selected renal sectionsRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeAMBIEN CR: renal conclusion is extrapolated from immediate-release dataAMBIEN CR: selected renal study limitations
Choose two source checkboxes below.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

An RX mirror and its underlying label are not independent clinical confirmations.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d934da3-bd77-4470-e063-6294a90a64f5

Product identity and scope

Adult oral AMBIEN CR extended-release tablets. Not immediate-release or sublingual zolpidem; usual dosing and safety restrictions still apply.

RDM71-zolpidem-ambien-cr-scope · Source section: Product identity and scopeRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

AMBIEN CR: renal conclusion is extrapolated from immediate-release data

Open original reference

Open / share this exact local source

DailyMed / product prescribing information · Adult oral AMBIEN CR extended-release tablets. Not immediate-release or sublingual zolpidem; usual dosing and safety restrictions still apply.

Renal method: Renal conclusion supported by an immediate-release ESRD/hemodialysis study
Source date: 08/2024
Retrieved: 2026-11-07

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.
Before using this finding

Not hemodialyzable does not supply a new supplemental-dose regimen.

Dialysis evidence: Removal information only - not a dialysis regimen

Selected named sections summarized; not a complete monograph or independent clinician approval.

Section 12.3, renal impairment; boxed warning context

The label states that renal dose adjustment is not necessary, but AMBIEN CR was not directly studied in renal impairment. The supporting study used immediate-release zolpidem in 11 patients with ESRD receiving hemodialysis. Zolpidem was not hemodialyzable. The historical immediate-release study dose is not a CR prescribing recommendation. Age, sex, hepatic status, next-day impairment and the boxed complex-sleep-behavior warning remain relevant despite the renal conclusion.

RDM71-zolpidem-ambien-cr-label-1 · Source locator: Section 12.3, renal impairment; boxed warning context

Source identity and provenance
Source family
product_label
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d934da3-bd77-4470-e063-6294a90a64f5
Retrieved
2026-11-07
Renal-function method
Renal conclusion supported by an immediate-release ESRD/hemodialysis study
Source date/version
08/2024
Hash meaning
Locally authored summary text; not original source HTML, XML or PDF bytes
Local summary SHA-256
d9904f4af559b238ac3a1430fe3f77cd3cdaa28f8dfa3b0284629f931bfbf4b4
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

AMBIEN CR: selected renal study limitations

Open original reference

Open / share this exact local source

GlobalRPh RX List / label mirror · Adult oral AMBIEN CR extended-release tablets. Not immediate-release or sublingual zolpidem; usual dosing and safety restrictions still apply.

Renal method: Immediate-release ESRD/HD study supporting CR label conclusion
Source date: Not established in reviewed passage
Retrieved: 2026-11-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.
Before using this finding

Confirm product, indication, renal measure and dialysis modality before applying.

Dialysis evidence: Removal information only - not a dialysis regimen

Selected named sections summarized; not a complete monograph or independent clinician approval.

Selected renal sections

The mirror describes the lack of a direct CR renal study and the immediate-release ESRD/hemodialysis evidence supporting the no-adjustment conclusion. It reports that zolpidem is not hemodialyzable. This does not make immediate-release and CR doses interchangeable.

RDM71-zolpidem-ambien-cr-rx-1 · Source locator: Selected renal sections

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/ambien-cr-drug/
Retrieved
2026-11-07
Renal-function method
Immediate-release ESRD/HD study supporting CR label conclusion
Source date/version
Not established in reviewed passage
Hash meaning
Locally authored summary text; not original source HTML, XML or PDF bytes
Local summary SHA-256
dc9e62633790b6edbb7535ef4403a06db6407a26a9defb30dd28631ea42fd29b

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2d934da3-bd77-4470-e063-6294a90a64f5
Source retrieval
2026-11-07. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
6540213eb6784c20ce87ec0b7f4b95c13f413ef4f15a850a86e4c8d25b357cc1
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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