GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Zileuton extended-release tablets (ZYFLO CR)

Local RX List renal extractBase record retrieved 2026-09-07See the evidence for this drug1 sources available - open source summaries, references and comparisons

ZYFLO CR

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Rxlist source

GlobalRPh RX List - ZYFLO CR

Product / population
Oral extended-release zileuton; source renal study used immediate-release drug.
Renal measure
CrCl and hemodialysis; qualitative label recommendation.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

No renal dosage change is required, including during hemodialysis, according to this source. The supporting renal study used immediate-release zileuton; less than 0.5% was removed by hemodialysis. That formulation distinction is retained rather than presenting the study as a direct extended-release trial. Hepatic restrictions and monitoring remain independent of the renal no-adjustment finding.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/zyflo-cr-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Evidence sources and renal implications

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GlobalRPh RX List

GlobalRPh RX List - ZYFLO CR

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.

Oral extended-release zileuton; source renal study used immediate-release drug.

Renal method: CrCl and hemodialysis; qualitative label recommendation.
Retrieved: 2026-09-07

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - ZYFLO CR
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/zyflo-cr-drug/

Exact product and population

Oral extended-release zileuton; source renal study used immediate-release drug.

RDM37-SCOPE-zileuton-zyflo-cr · Source section: Selected source product scopeRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - ZYFLO CR

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GlobalRPh-hosted RX List · Oral extended-release zileuton; source renal study used immediate-release drug.

Renal method: CrCl and hemodialysis; qualitative label recommendation.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

No renal dosage change is required, including during hemodialysis, according to this source. The supporting renal study used immediate-release zileuton; less than 0.5% was removed by hemodialysis. That formulation distinction is retained rather than presenting the study as a direct extended-release trial. Hepatic restrictions and monitoring remain independent of the renal no-adjustment finding.

RDM37-rxlist-zileuton-zyflo-cr-61929a73f9-C1 · Source locator: Use in Specific Populations: Renal Impairment.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/zyflo-cr-drug/
Retrieved
2026-09-07
Renal-function method
CrCl and hemodialysis; qualitative label recommendation.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
f1f9c7607c48f4ac5147a69e612b20c3603bcd1470c51730c5f00f034982affe

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/zyflo-cr-drug/
Source retrieval
2026-09-07. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
85d03781bfdea8a49d52491cd8b59e15a3ee630d7267a329461549c863e1221c
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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