GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Valacyclovir

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons
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Rxlist source

GlobalRPh RX List - Valtrex

Product / population
Selected adult immunocompetent herpes-zoster regimen; not a genital-herpes, neonatal or pediatric renal schedule.
Renal measure
Creatinine clearance in mL/min; adult indication-specific table.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Adult indication and pediatric evidence boundary are distinct; this is not the entire multi-indication table.

Renal dosing, restrictions and evidence limits

For adult herpes zoster, the source lists 1 g every eight hours at CrCl >=50, 1 g every twelve hours at 30-49, 1 g every 24 hours at 10-29, and 500 mg every 24 hours below 10. The usual zoster course is seven days. On hemodialysis days, give the recommended dose after dialysis. The source has different rows for cold sores, genital-herpes treatment and suppression; do not transfer this zoster schedule to those indications. Pediatric use with CrCl below 50 mL/min/1.73 m2 lacks data. Renal accumulation and neurotoxicity precautions remain relevant even when an adjusted regimen is chosen.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/valtrex-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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Source-first renal review

Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - Valtrex

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected adult immunocompetent herpes-zoster regimen; not a genital-herpes, neonatal or pediatric renal schedule.

Renal method: Creatinine clearance in mL/min; adult indication-specific table.
Retrieved: 2026-09-07

Read local renal resultOpen original reference
Professional guidance

UCSF - valacyclovir: indication-specific oral dosing

Adults; valacyclovir oral systemic formulations.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

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Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

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Original content / product scopeGlobalRPh RX List - ValtrexUCSF - valacyclovir: indication-specific oral dosing
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

The source HD summary does not distinguish indications. It must not override the indication-specific one-dose labialis or suppressive schedules without current-label review.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/valacyclovir/

Usual Dosing (Adults)

Herpes zoster: 1 g orally three times daily for 7 days. Primary genital herpes: 1 g twice daily for 10 days. Recurrent genital herpes: 500 mg twice daily for 5 days. Chronic genital suppression: 500 mg daily. Herpes labialis: 2 g every 12 hours for 1 day.

GRPH-valacyclovir-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl above 50 mL/min: no change in the original summary.

CrCl 30-49: zoster 1 g every 12 hours; labialis 1 g every 12 hours for two doses; initial genital episode 1 g every 12 hours; recurrent genital episode 500 mg every 12 hours; suppression 0.5-1 g daily.

CrCl 10-29: zoster 1 g daily; labialis 500 mg every 12 hours for two doses; initial genital episode 1 g daily; recurrent genital episode 500 mg daily; suppression 500 mg every 24-48 hours.

CrCl below 10: zoster 500 mg daily; labialis 500 mg once; initial/recurrent genital episodes 500 mg daily; suppression 500 mg every 24-48 hours.

GRPH-valacyclovir-02 · Source section: Renal DosingRenal section finder

Hemodialysis

The separate source summary gives 500 mg orally every 24 hours, after dialysis on HD days.

GRPH-valacyclovir-03 · Source section: HemodialysisRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - Valtrex

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GlobalRPh-hosted RX List · Selected adult immunocompetent herpes-zoster regimen; not a genital-herpes, neonatal or pediatric renal schedule.

Renal method: Creatinine clearance in mL/min; adult indication-specific table.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For adult herpes zoster, the source lists 1 g every eight hours at CrCl >=50, 1 g every twelve hours at 30-49, 1 g every 24 hours at 10-29, and 500 mg every 24 hours below 10. The usual zoster course is seven days. On hemodialysis days, give the recommended dose after dialysis. The source has different rows for cold sores, genital-herpes treatment and suppression; do not transfer this zoster schedule to those indications. Pediatric use with CrCl below 50 mL/min/1.73 m2 lacks data. Renal accumulation and neurotoxicity precautions remain relevant even when an adjusted regimen is chosen.

RDM40-rxlist-valacyclovir-066f68064c-C1 · Source locator: Selected renal dosing, renal impairment, toxicity and pharmacokinetic subsections as identified in the summary.

Source-specific limits

Adult indication and pediatric evidence boundary are distinct; this is not the entire multi-indication table.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/valtrex-drug/
Retrieved
2026-09-07
Renal-function method
Creatinine clearance in mL/min; adult indication-specific table.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
3b3d4dd936f1ed7ca26d1f1a7753d88745312738122ef975fe6d3167045864ea
Separate professional-source layer

University and professional protocols

Professional

UCSF - valacyclovir: indication-specific oral dosing

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UCSF Infectious Diseases Management Program · Adults; valacyclovir oral systemic formulations.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Limits that apply to these rows

Choose the indication rather than applying a zoster regimen to HSV.

Initial orolabial/genital HSV or recurrent episode with HIV - oral
CrCl, mL/minSource-specific dose / instruction
>=501000 mg every 12 hours
30-491000 mg every 12 hours
10-291000 mg every 24 hours
<10500 mg every 24 hours
HSV suppression or separately listed recurrent-episode regimen - oral
CrCl, mL/minSource-specific dose / instruction
>=50500 mg every 12 hours
30-49500 mg every 12 hours
10-29500 mg every 24 hours
<10500 mg every 24 hours
Primary varicella or herpes zoster - oral
CrCl, mL/minSource-specific dose / instruction
>=501000 mg every 8 hours
30-491000 mg every 12 hours
10-291000 mg every 24 hours
<10500 mg every 24 hours
Dialysis guidance - separate source-specific schedules
Valacyclovir dialysis
Dialysis setting / indicationSource-specific schedule
IHD500 mg orally each evening
Continuous HDInsufficient data; obtain ID guidance
Read the retained text before reformatting

Adult CrCl bands are >=50 / 30-49 / 10-29 / <10 mL/min. For initial orolabial/genital HSV or recurrent-episode treatment with HIV, doses are respectively 1000 / 1000 / 1000 / 500 mg, at intervals of 12 / 12 / 24 / 24 hours. For HSV suppression or the separately listed recurrent-episode regimen, use 500 mg every 12 / 12 / 24 / 24 hours. Primary varicella or herpes zoster: 1000 mg every 8 / 12 / 24 hours, then 500 mg daily in the lowest band.

The intermittent-HD table lists 500 mg orally each evening. Continuous-HD data are insufficient; obtain ID guidance. Select the indication rather than transferring a zoster dose to HSV.

RDM30-025-valacyclovir-1 · Source locator: UCSF - valacyclovir: indication-specific oral dosing; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/valacyclovir
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
000714ac8b13813420508a7b8f258acfa9c826b508893a219ddeff7e28903840

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 1 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/valacyclovir/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
c614a32bfdcf873b986ba6ee8a11c08733c0378602913ee844ff10b1966e6258
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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