GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Trimethoprim - single agent

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons
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Historical source

Original GlobalRPh source

Product / population
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Renal measure
Use the method specified in the original source

Historical source: not automatically current. Review current official labeling and separately attributed additions before use.

Single-agent trimethoprim, not TMP/SMX. Original avoidance and alternative dosing are both retained.

Usual Dosing (Adults)

100 mg every 12 hours or 200 mg every 24 hours.

Renal Dosing

CrCl above 30 mL/min: no change. 15-30: 100 mg every 18 hours or 50 mg every 12 hours. Below 15: 100 mg every 24 hours or avoid.

Hemodialysis

Avoid, or 100 mg every 24 hours with the dose after dialysis on HD days.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/trimethoprim/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Evidence sources and renal implications

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Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

Single-agent trimethoprim, not TMP/SMX. Original avoidance and alternative dosing are both retained.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/trimethoprim/

Usual Dosing (Adults)

100 mg every 12 hours or 200 mg every 24 hours.

GRPH-trimethoprim-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

CrCl above 30 mL/min: no change. 15-30: 100 mg every 18 hours or 50 mg every 12 hours. Below 15: 100 mg every 24 hours or avoid.

GRPH-trimethoprim-02 · Source section: Renal DosingRenal section finder

Hemodialysis

Avoid, or 100 mg every 24 hours with the dose after dialysis on HD days.

GRPH-trimethoprim-03 · Source section: HemodialysisRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/trimethoprim/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
3dc55a51905ec21afe3a2b3c431c22a9da095e6456622feff1d5fbe4be4ee8d6
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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