GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Tramadol/acetaminophen (ULTRACET)

Local RX List renal extractBase record retrieved 2026-09-07See the evidence for this drug1 sources available - open source summaries, references and comparisons

Ultracet

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Rxlist source

GlobalRPh RX List - Ultracet

Product / population
Adult immediate-release oral fixed combination, 37.5 mg/325 mg per tablet.
Renal measure
CrCl in mL/min

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

For creatinine clearance below 30 mL/min, do not exceed two ULTRACET tablets every 12 hours. Each tablet contains tramadol 37.5 mg and acetaminophen 325 mg. Use is limited to short-term acute pain treatment of five days or less. Hemodialysis removes less than 7% of tramadol and its active metabolite during four hours in tramadol-alone studies. Monitor sedation, respiratory depression and hypotension. This fixed combination is not interchangeable with a tramadol-only renal maximum; account for all other acetaminophen and tramadol exposure.

Source revision: April 2022 | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/ultracet-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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GlobalRPh RX List

GlobalRPh RX List - Ultracet

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult immediate-release oral fixed combination, 37.5 mg/325 mg per tablet.

Renal method: CrCl in mL/min
Retrieved: 2026-09-07

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Original content / product scopeGlobalRPh RX List - Ultracet
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/ultracet-drug/

Exact product and population

Adult immediate-release oral fixed combination, 37.5 mg/325 mg per tablet.

RDM36-SCOPE-tramadol-acetaminophen-ultracet · Source section: Selected source product scopeRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - Ultracet

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GlobalRPh-hosted RX List · Adult immediate-release oral fixed combination, 37.5 mg/325 mg per tablet.

Renal method: CrCl in mL/min
Source date: April 2022
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

For creatinine clearance below 30 mL/min, do not exceed two ULTRACET tablets every 12 hours. Each tablet contains tramadol 37.5 mg and acetaminophen 325 mg. Use is limited to short-term acute pain treatment of five days or less. Hemodialysis removes less than 7% of tramadol and its active metabolite during four hours in tramadol-alone studies. Monitor sedation, respiratory depression and hypotension. This fixed combination is not interchangeable with a tramadol-only renal maximum; account for all other acetaminophen and tramadol exposure.

RDM36-rxlist-tramadol-acetaminophen-ultracet-319410efc0-C1 · Source locator: Strengths; indication; renal impairment; dosage modifications.

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/ultracet-drug/
Retrieved
2026-09-07
Renal-function method
CrCl in mL/min
Source date/version
April 2022
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
55370e797e725cc943d1e34183fe0e822ca6b5594850801d7cfb3a22d9352504

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/rx-list/ultracet-drug/
Source retrieval
2026-09-07. This is not the source publication or label revision date.
Original source type
rxlist summary
Local text SHA-256
3b2a1f86226ea61175721aa10890183665ad8567dc61a4778d226b289c5c37c5
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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