GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Tirofiban

GlobalRPh source pageBase record retrieved 2026-09-05See the evidence for this drug1 sources available - open source summaries, references and comparisons

Aggrastat

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Renal measure
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Indication and usual adult dose

AGGRASTAT for non-ST-elevation acute coronary syndrome reduces the combined thrombotic cardiovascular endpoint of death, MI, refractory ischemia or repeat cardiac procedure. IV only: 25 micrograms/kg within 5 minutes, then 0.15 micrograms/kg/min for up to 18 hours.

Original preparation and compatibility instructions

Inspect for particles/discoloration; use only clear solution with intact seal. Remove the INTRAVIA foil overpouch; temporary plastic opacity from sterilization moisture may diminish. Squeeze the inner bag to check for leaks; discard if leaking or sterility is questionable. Do not connect bags in series because of air-embolism risk.

Withdraw the bolus from the 15 mL premixed bolus vial, or use the 100 mL premixed vial/bags. Do not dilute. Administer by syringe or IV pump within 5 minutes, then immediately begin maintenance from the 100 mL vial/bag using a pump. Discard remaining solution.

Bolus volume: 25 micrograms/kg x body weight / 250 micrograms/mL for the 15 mL vial, or divide by 50 micrograms/mL for the 100 mL vial/bag.

For CrCl above 60, maintenance mL/hour = 0.15 micrograms/kg/min x weight x 60 / 50 micrograms/mL.

The original same-line compatibility list includes heparin, atropine sulfate, dobutamine, dopamine, epinephrine HCl, famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride and propranolol HCl. Do not share the line with diazepam. Do not add drugs to, or withdraw solution directly with a syringe from, the INTRAVIA bag.

Renal Dosing

CrCl at or below 60 mL/min: unchanged 25 micrograms/kg bolus within 5 minutes, then 0.075 micrograms/kg/min for up to 18 hours.

At 50 micrograms/mL, renal-adjusted mL/hour = 0.075 micrograms/kg/min x weight x 60 / 50 micrograms/mL.

Hemodialysis

Insufficient data.

Source revision: Historical source; revision not established here | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://globalrph.com/renal/tirofiban/

Scope: Preserved historical source; no fresh clinical approval GlobalRPh v6.6.

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Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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Renal dosing and precautions

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Original content / product scope
Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/tirofiban/

Indication and usual adult dose

AGGRASTAT for non-ST-elevation acute coronary syndrome reduces the combined thrombotic cardiovascular endpoint of death, MI, refractory ischemia or repeat cardiac procedure. IV only: 25 micrograms/kg within 5 minutes, then 0.15 micrograms/kg/min for up to 18 hours.

GRPH-tirofiban-01 · Source section: Indication and usual adult doseRenal section finder

Original preparation and compatibility instructions

Inspect for particles/discoloration; use only clear solution with intact seal. Remove the INTRAVIA foil overpouch; temporary plastic opacity from sterilization moisture may diminish. Squeeze the inner bag to check for leaks; discard if leaking or sterility is questionable. Do not connect bags in series because of air-embolism risk.

Withdraw the bolus from the 15 mL premixed bolus vial, or use the 100 mL premixed vial/bags. Do not dilute. Administer by syringe or IV pump within 5 minutes, then immediately begin maintenance from the 100 mL vial/bag using a pump. Discard remaining solution.

Bolus volume: 25 micrograms/kg x body weight / 250 micrograms/mL for the 15 mL vial, or divide by 50 micrograms/mL for the 100 mL vial/bag.

For CrCl above 60, maintenance mL/hour = 0.15 micrograms/kg/min x weight x 60 / 50 micrograms/mL.

The original same-line compatibility list includes heparin, atropine sulfate, dobutamine, dopamine, epinephrine HCl, famotidine injection, furosemide, lidocaine, midazolam HCl, morphine sulfate, nitroglycerin, potassium chloride and propranolol HCl. Do not share the line with diazepam. Do not add drugs to, or withdraw solution directly with a syringe from, the INTRAVIA bag.

GRPH-tirofiban-02 · Source section: Original preparation and compatibility instructionsRenal section finder

Renal Dosing

CrCl at or below 60 mL/min: unchanged 25 micrograms/kg bolus within 5 minutes, then 0.075 micrograms/kg/min for up to 18 hours.

At 50 micrograms/mL, renal-adjusted mL/hour = 0.075 micrograms/kg/min x weight x 60 / 50 micrograms/mL.

GRPH-tirofiban-03 · Source section: Renal DosingRenal section finder

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 0 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/tirofiban/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
fc0a9e772527a70c53f40fa3e16fb70b2e1fc2246a5d8bf487a5a46f1613a9a8
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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