Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist
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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.
1 additional source qualifications - review before use
Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal measure
Renal reduction not recommended; hepatic adjustment is separate.
Source revision
Revision date not stated in the reviewed page.
Retrieved
2026-09-05 (not the revision date)
Dosing / renal protocol and limits
Adult IV treatment starts with 100 mg once, followed by 50 mg every 12 hours. Renal dysfunction and hemodialysis do not change that schedule. Severe hepatic dysfunction instead uses the same loading dose followed by 25 mg every 12 hours.
Some selected infections may receive 200 mg initially followed by 100 mg every 12 hours, but only with infectious-diseases/stewardship input. The higher schedule is not a renal adjustment and must not replace the standard schedule automatically.
Source revision: Revision date not stated in the reviewed page. | Retrieved: 2026-09-05. Retrieval date is not the revision date.
Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.
Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.
Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR. Retrieved: 2026-09-05
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All source summaries, original wording and provenance
Before applying a renal protocol
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No patient-specific dose is calculated. Context choices only display reminders; they do not validate, hide or change any regimen.
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Choose sources below, then open a print-ready comparison with product scope, renal method, dates and cautions. Links can pin the exact local cards; they never contain patient values or choose a dose.
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Source-by-source comparison
These protocols may disagree and may apply to different settings. This view does not reconcile or endorse a patient-specific regimen.
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Renal-context checklist: population, kidney trend and dialysis
These prompts are a reading aid, not a prescription checklist or proof that all requirements have been met. No selections are stored or sent to a server.
Read the exact source scope, renal metric and date before selecting a row. No applicability assessment has been performed.
These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.
Source scope / renal recommendation differences
Tygacil - product and source limitations
Review the indication, boxed mortality warning and separate hepatic dosing instructions.
How to use this: Apply only to the stated formulation, indication and renal population.
Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.
Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Official source
TYGACIL - adult renal and hepatic distinctions
Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Method: No renal-function dose bands specified for this summary.
Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.
Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.
Compare or copy source versions
All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.
Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Adult Tigecycline (Tygacil). Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.
SCOPE-tigecycline · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Renal method: No renal-function dose bands specified for this summary. Source date: DailyMed updated 2025-11-18. Retrieved: 2026-09-05
Locally included source-specific summary. Regimen differences are not automatically resolved.
Dosing / renal protocol and limits
Adult labeled infections: 100 mg IV loading dose, then 50 mg IV every 12 hours; infuse over approximately 30-60 minutes. Renal impairment and hemodialysis do not require dose changes; hemodialysis does not remove tigecycline.
Severe hepatic impairment is different: retain the 100-mg loading dose but use 25 mg every 12 hours for Child-Pugh C. The boxed warning identifies increased all-cause mortality; reserve use when suitable alternatives are lacking. Hospital-acquired/ventilator-associated pneumonia and diabetic-foot infection are not labeled indications. Do not infer pediatric dosing from this adult regimen.
RDM30-078-tigecycline-1 · Source locator: TYGACIL - adult renal and hepatic distinctions; renal/dosing sections and stated qualifiers
DailyMed / product prescribing information · Tigecycline (Tygacil), IV injection
Renal method: Renal impairment categories as defined by the cited product label Source date: DailyMed SPL version 50, posted Nov 19, 2025 Retrieved: 2026-11-07
Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.
Renal guidance: Prescribing information, renal precautions and clinical pharmacology
No renal reduction is needed for IV tigecycline, including in patients receiving hemodialysis. Review the indication, boxed mortality warning and separate hepatic dosing instructions.
GlobalRPh RX List / product-label mirror · Tigecycline (Tygacil), IV injection
Renal method: Use the renal measure explicitly present in the RX passage. Source date: Mirror revision not established in the reviewed passage. Retrieved: 2026-11-07
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.
UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.
Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR. Source date: 5th edition; 2019 copyright; historical reference Retrieved: 2026-09-05
Historical handbook cross-check; not a current U.S. protocol
Historical renal / replacement-therapy guidance
The 20-50, 10-20 and <10 mL/min bands retain the usual indication-specific dose. The listed regimen is 100 mg loading then 50 mg twice daily. HD/PD removal is described as absent; high-flux/continuous removal is unknown, with usual dosing retained. The renal statement does not supersede the selected U.S. boxed warning or severe-hepatic dose reduction.
HB30-tigecycline-1 · Source locator: Printed page 998: renal impairment, RRT and other information
Source-specific limits
Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.
Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 998; uploaded PDF p. 1017
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.
Renal method: Renal reduction not recommended; hepatic adjustment is separate. Source date: Revision date not stated in the reviewed page. Retrieved: 2026-09-05
Locally included source-specific summary. Regimen differences are not automatically resolved.
Dosing / renal protocol and limits
Adult IV treatment starts with 100 mg once, followed by 50 mg every 12 hours. Renal dysfunction and hemodialysis do not change that schedule. Severe hepatic dysfunction instead uses the same loading dose followed by 25 mg every 12 hours.
Some selected infections may receive 200 mg initially followed by 100 mg every 12 hours, but only with infectious-diseases/stewardship input. The higher schedule is not a renal adjustment and must not replace the standard schedule automatically.
Additional summaries stored on this page: 2 official-label, 1 RX List, 1 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.
This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.
