GlobalRPh Renal Dosing Masterv6.6
Evidence addition

Tigecycline (Tygacil)

Local official-label summaryBase record retrieved 2026-09-05See the evidence for this drug3 sources available - open source summaries, references and comparisons

Tygacil

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Renal guidance at a glance

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Official source

TYGACIL - adult renal and hepatic distinctions

Product / population
Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.
Renal measure
No renal-function dose bands specified for this summary.

Dosing / renal protocol and limits

Adult labeled infections: 100 mg IV loading dose, then 50 mg IV every 12 hours; infuse over approximately 30-60 minutes. Renal impairment and hemodialysis do not require dose changes; hemodialysis does not remove tigecycline.

Severe hepatic impairment is different: retain the 100-mg loading dose but use 25 mg every 12 hours for Child-Pugh C. The boxed warning identifies increased all-cause mortality; reserve use when suitable alternatives are lacking. Hospital-acquired/ventilator-associated pneumonia and diabetic-foot infection are not labeled indications. Do not infer pediatric dosing from this adult regimen.

Source revision: DailyMed updated 2025-11-18. | Retrieved: 2026-09-05. Retrieval date is not the revision date.

Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ccdb48e-c14a-4eeb-348c-4920ccfd7465

Scope: Locally included source-specific summary. Regimen differences are not automatically resolved. GlobalRPh v6.6.

Full source card / provenance

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Source-first renal review

Evidence sources and renal implications

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Official product label

TYGACIL - adult renal and hepatic distinctions

Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Retrieved: 2026-09-05

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Professional guidance

UCSF - tigecycline

Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: Renal reduction not recommended; hepatic adjustment is separate.
Retrieved: 2026-09-05

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Handbook

Renal Drug Handbook, 5th edition - Tigecycline

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Retrieved: 2026-09-05

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Renal-context checklist: population, kidney trend and dialysis

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See source-specific renal methods and the clinical interpretation guide for the supporting context.

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Renal dosing and precautions

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Handbook source

Renal Drug Handbook, 5th edition - Tigecycline

Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.

Historical renal / replacement-therapy guidanceRead this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scopeTYGACIL - adult renal and hepatic distinctionsUCSF - tigecyclineRenal Drug Handbook, 5th edition - Tigecycline
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ccdb48e-c14a-4eeb-348c-4920ccfd7465

Product and population scope

Adult Tigecycline (Tygacil). Use only the product, route, indication and renal-replacement setting explicitly stated in the source protocol selected below. Sources are alternatives to compare, not ingredients of a blended regimen.

SCOPE-tigecycline · Source section: Editorial scope; each clinical recommendation is separately attributed belowRenal section finder
Separate U.S. product-label layer

FDA / DailyMed dosing and renal information

Official

TYGACIL - adult renal and hepatic distinctions

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NIH/NLM DailyMed - U.S. product labeling · Adults; named product and route only. Selected dosing and renal summary, not the full prescribing information.

Renal method: No renal-function dose bands specified for this summary.
Source date: DailyMed updated 2025-11-18.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adult labeled infections: 100 mg IV loading dose, then 50 mg IV every 12 hours; infuse over approximately 30-60 minutes. Renal impairment and hemodialysis do not require dose changes; hemodialysis does not remove tigecycline.

Severe hepatic impairment is different: retain the 100-mg loading dose but use 25 mg every 12 hours for Child-Pugh C. The boxed warning identifies increased all-cause mortality; reserve use when suitable alternatives are lacking. Hospital-acquired/ventilator-associated pneumonia and diabetic-foot infection are not labeled indications. Do not infer pediatric dosing from this adult regimen.

RDM30-078-tigecycline-1 · Source locator: TYGACIL - adult renal and hepatic distinctions; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ccdb48e-c14a-4eeb-348c-4920ccfd7465
Retrieved
2026-09-05
DailyMed Set ID
2ccdb48e-c14a-4eeb-348c-4920ccfd7465
Renal-function method
No renal-function dose bands specified for this summary.
Source date/version
DailyMed updated 2025-11-18.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
4299da98c9e08f3a1fc12a89ab06ee4a62d3147e377554bc24cf18354b876e78
Separate handbook layer

Renal Drug Handbook cross-check

Handbook

Renal Drug Handbook, 5th edition - Tigecycline

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UK Renal Pharmacy Group / CRC Press · Historical adult renal/RRT summary. U.S. product identity anchored to the separate locally included DailyMed label. This is not a current U.S. product label.

Renal method: Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date: 5th edition; 2019 copyright; historical reference
Retrieved: 2026-09-05

Historical handbook cross-check; not a current U.S. protocol

Historical renal / replacement-therapy guidance

The 20-50, 10-20 and <10 mL/min bands retain the usual indication-specific dose. The listed regimen is 100 mg loading then 50 mg twice daily. HD/PD removal is described as absent; high-flux/continuous removal is unknown, with usual dosing retained. The renal statement does not supersede the selected U.S. boxed warning or severe-hepatic dose reduction.

HB30-tigecycline-1 · Source locator: Printed page 998: renal impairment, RRT and other information

Source-specific limits

Separate source recommendation, not proof of agreement or contemporary clinical validation. Dialysis predictions are retained with their original certainty.

Source identity and provenance
Retrieved
2026-09-05
Handbook page
5th edition, printed p. 998; uploaded PDF p. 1017
Renal-function method
Book table headed GFR (mL/min); its preface states renal adjustments generally derive from Cockcroft-Gault CrCl. Do not silently relabel as indexed eGFR.
Source date/version
5th edition; 2019 copyright; historical reference
U.S. product identity basis
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ccdb48e-c14a-4eeb-348c-4920ccfd7465
Hash meaning
Local paraphrase; original book not redistributed
Local summary SHA-256
1d18b68c702e5868070e1157d7c7481b90c7c3b4dc1c1ad6940d1d3ac235caa4
Separate professional-source layer

University and professional protocols

Professional

UCSF - tigecycline

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UCSF Infectious Diseases Management Program · Adults; source-specific institutional guidance. Match route, indication and renal replacement modality.

Renal method: Renal reduction not recommended; hepatic adjustment is separate.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Adult IV treatment starts with 100 mg once, followed by 50 mg every 12 hours. Renal dysfunction and hemodialysis do not change that schedule. Severe hepatic dysfunction instead uses the same loading dose followed by 25 mg every 12 hours.

Some selected infections may receive 200 mg initially followed by 100 mg every 12 hours, but only with infectious-diseases/stewardship input. The higher schedule is not a renal adjustment and must not replace the standard schedule automatically.

RDM30-036-tigecycline-1 · Source locator: UCSF - tigecycline; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/tigecycline
Retrieved
2026-09-05
Renal-function method
Renal reduction not recommended; hepatic adjustment is separate.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
b8d69af4c539a752323412103a713c870e21194d39534c1262466b20f04e3018

Provenance and preservation

Additional summaries stored on this page: 1 official-label, 0 RX List, 1 professional, 1 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2ccdb48e-c14a-4eeb-348c-4920ccfd7465
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
multisource addition
Local text SHA-256
0bdab8356aa6099a4f9a47e155358d36b960d6adc28bd83f8d7e369f64100a64
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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