Theophylline extended-release (UNIPHYL) | GlobalRPh Renal Dosing Master

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An adult renal statement cannot be extended to neonates

The source distinguishes adult and older-child renal handling from neonatal elimination. Its neonatal warning is not a neonatal extended-release-tablet protocol.

Before applying: Confirm age and formulation, and use therapeutic concentration monitoring with other clearance-changing conditions. No renal adjustment does not mean no monitoring.

Also check: An adult renal statement cannot be extended to neonates

Rxlist source

GlobalRPh RX List - Uniphyl

Product / population: UNIPHYL oral ER product; adult renal statement with explicit neonatal limitation.
Renal measure: Age-dependent renal elimination; no adult CrCl threshold supplied

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

The source states renal insufficiency alone does not require dose adjustment in adults and children older than three months, including ESRD. It separately warns that neonates excrete much more unchanged theophylline and require dose reduction and frequent serum-concentration monitoring when renal function declines. That neonatal pharmacology statement does not establish that this extended-release tablet is an appropriate neonatal formulation. Age, hepatic disease, heart failure and smoking changes can independently alter clearance. Use concentration-guided dosing rather than interpreting no renal adjustment as no monitoring.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/uniphyl-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

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GlobalRPh RX List

GlobalRPh RX List - Uniphyl

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.

UNIPHYL oral ER product; adult renal statement with explicit neonatal limitation.

Renal method: Age-dependent renal elimination; no adult CrCl threshold supplied
Retrieved: 2026-09-07

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Jump to renal guidance Read 1 difference / caution notes Clinician guide

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Source differences and product cautions

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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

population scope

An adult renal statement cannot be extended to neonates

The source distinguishes adult and older-child renal handling from neonatal elimination. Its neonatal warning is not a neonatal extended-release-tablet protocol.

How to use this: Confirm age and formulation, and use therapeutic concentration monitoring with other clearance-changing conditions. No renal adjustment does not mean no monitoring.

GlobalRPh RX List - Uniphyl

Source-specific interpretation; independent clinician adjudication pending.

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Renal dosing and precautions

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New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

Rxlist source

GlobalRPh RX List - Uniphyl

UNIPHYL oral ER product; adult renal statement with explicit neonatal limitation.

Method: Age-dependent renal elimination; no adult CrCl threshold supplied

Renal dosing, restrictions and evidence limits Read this complete source summary

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

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Original content / product scope GlobalRPh RX List - Uniphyl

Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Locally stored source content

Exact product and population

Product identity selected for the separately displayed source protocols below. Reference: https://globalrph.com/rx-list/uniphyl-drug/

Exact product and population

UNIPHYL oral ER product; adult renal statement with explicit neonatal limitation.

RDM36-SCOPE-theophylline-uniphyl · Source section: Selected source product scopeRenal section finder

Locally imported selected renal sections

GlobalRPh RX List renal information

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GlobalRPh RX List - Uniphyl

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GlobalRPh-hosted RX List · UNIPHYL oral ER product; adult renal statement with explicit neonatal limitation.

Renal method: Age-dependent renal elimination; no adult CrCl threshold supplied
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.

Qualified no-adjustment statement. Apply only to the population, product and renal range described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

RDM36-rxlist-theophylline-uniphyl-1c0c29c238-C1 · Source locator: Special populations: renal insufficiency; geriatric, hepatic and CHF effects.

Source identity and provenance

Source family: product_label_mirror
Source: https://globalrph.com/rx-list/uniphyl-drug/
Retrieved: 2026-09-07
Renal-function method: Age-dependent renal elimination; no adult CrCl threshold supplied
Source date/version: Source revision date not established in selected retrieval.
Hash meaning: SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256: d4c00306d62fe140bebcbd4b9bf59f2a833ed7452f9c55dea26a82ead865b03e

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source: https://globalrph.com/rx-list/uniphyl-drug/
Source retrieval: 2026-09-07. This is not the source publication or label revision date.
Original source type: rxlist summary
Local text SHA-256: 6afd335cd66c7ac141d4e9c8b45f5c853b1c311be38055a85a0d9907c34117ac
Import versus clinical validation: Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.

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