DailyMed / TERLIVAZ exact label
- Product / population
- TERLIVAZ terlipressin IV injection in adults with hepatorenal syndrome and rapid kidney-function reduction. This is a response-guided HRS regimen, not a stable-CKD CrCl table.
- Renal measure
- SCr, mg/dL and percent response; oxygenation
Official Figure 1 visually inspected (turn906730view3); the highlights say the increased dose may be used. Independent clinical adjudication remains pending.
Renal dosing, restrictions and evidence limits
Days 1-3: 0.85 mg IV every 6 hours over 2 minutes. On day 4, stop if SCr is at or above baseline; if SCr has fallen by at least 30%, continue 0.85 mg every 6 hours; if it has fallen by less than 30%, the highlights allow increase to 1.7 mg every 6 hours. Continue until 24 hours after two consecutive SCr values <=1.5 mg/dL at least 2 hours apart, or at most 14 days.
Benefit is unlikely above SCr 5 mg/dL. Do not start during hypoxia; monitor continuously and stop if SpO2 falls below 90%. Assess volume status and ACLF grade. This selected pathway does not replace full eligibility, ischemia and respiratory-risk review.
Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3a35b86c-f451-4fac-8499-43019e4da354